P22307: Non-specific lipid-transfer protein

General Information

Protein names	- Non-specific lipid-transfer protein - NSL-TP - 2.3.1.176 - Propanoyl-CoA C-acyltransferase - SCP-chi - SCPX - Sterol carrier protein 2 - SCP-2 - Sterol carrier protein X - SCP-X
Gene names	SCP2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22307

9 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform SCP2 of Non-specific lipid-transfer protein - Isoform 3 of Non-specific lipid-transfer protein - Isoform 4 of Non-specific lipid-transfer protein - Isoform 5 of Non-specific lipid-transfer protein - Isoform 6 of Non-specific lipid-transfer protein - Isoform 7 of Non-specific lipid-transfer protein - Isoform 8 of Non-specific lipid-transfer protein

Sequence View

        10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL         10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL         10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL         10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL         10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL         10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL         10         20         30         40         50         60
MSSSPWEPAT LRRVFVVGVG MTKFVKPGAE NSRDYPDLAE EAGKKALADA QIPYSAVDQA
        70         80         90        100        110        120
CVGYVFGDST CGQRAIYHSL GMTGIPIINV NNNCATGSTA LFMARQLIQG GVAECVLALG
       130        140        150        160        170        180
FEKMSKGSLG IKFSDRTIPT DKHVDLLINK YGLSAHPVAP QMFGYAGKEH MEKYGTKIEH
       190        200        210        220        230        240
FAKIGWKNHK HSVNNPYSQF QDEYSLDEVM ASKEVFDFLT ILQCCPTSDG AAAAILASEA
       250        260        270        280        290        300
FVQKYGLQSK AVEILAQEMM TDLPSSFEEK SIIKMVGFDM SKEAARKCYE KSGLTPNDID
       310        320        330        340        350        360
VIELHDCFST NELLTYEALG LCPEGQGATL VDRGDNTYGG KWVINPSGGL ISKGHPLGAT
       370        380        390        400        410        420
GLAQCAELCW QLRGEAGKRQ VPGAKVALQH NLGIGGAVVV TLYKMGFPEA ASSFRTHQIE
       430        440        450        460        470        480
AVPTSSASDG FKANLVFKEI EKKLEEEGEQ FVKKIGGIFA FKVKDGPGGK EATWVVDVKN
       490        500        510        520        530        540
GKGSVLPNSD KKADCTITMA DSDFLALMTG KMNPQSAFFQ GKLKITGNMG LAMKLQNLQL

QPGNAKL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P22307-1-unknown	MSSSPW...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P22307-1-unknown	MSSSPW...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82956
P22307-1-unknown	MSSSPW...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82960
P22307-1-unknown	MSSSPW...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82961
P22307-2-acetylation	SSSPWE...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P22307-2-acetylation	SSSPWE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P22307-2-acetylation	SSSPWE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163252
P22307-2-acetylation	SSSPWE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163253
P22307-2-acetylation	SSSPWE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163254
P22307-82-unknown	MTGIPI...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82957
P22307-82-unknown	MTGIPI...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96581
P22307-405-unknown	MGFPEA...	405		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82955
P22307-405-unknown	MGFPEA...	405		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82958
P22307-405-unknown	MGFPEA...	405		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P22307-405-unknown	MGFPEA...	405		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96434
P22307-405-unknown	MGFPEA...	405		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96433
P22307-405-unknown	MGFPEA...	405		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt96432
P22307-406-	GFPEAA...	406			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P22307-406-	GFPEAA...	406			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P22307-406-	GFPEAA...	406			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P22307-406-	GFPEAA...	406			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P22307-406-	GFPEAA...	406			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P22307-406-	GFPEAA...	406			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22307-406-unknown	GFPEAA...	406			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P22307-406-unknown	GFPEAA...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159972
P22307-406-unknown	GFPEAA...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159974
P22307-406-unknown	GFPEAA...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159973
P22307-406-unknown	GFPEAA...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159971
P22307-406-unknown	GFPEAA...	406		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159970
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	RMPI_untreated	23264352
P22307-425-	SSASDG...	425			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P22307-425-unknown	SSASDG...	425			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P22307-425-unknown	SSASDG...	425			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P22307-425-unknown	SSASDG...	425		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159978
P22307-425-unknown	SSASDG...	425		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159979
P22307-425-unknown	SSASDG...	425		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159981
P22307-425-unknown	SSASDG...	425		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159980
P22307-425-unknown	SSASDG...	425		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159977
P22307-425-unknown	SSASDG...	425		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159976
P22307-494-unknown	DCTITM...	494		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5683
P22307-494-unknown	DCTITM...	494		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141660
P22307-494-unknown	DCTITM...	494		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141805
P22307-494-unknown	DCTITM...	494		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152198
P22307-494-unknown	DCTITM...	494		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152785
P22307-494-unknown	DCTITM...	494		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153076

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDKKAD	493	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5683
...SDKKAD	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124840
...SDKKAD	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124986
...SDKKAD	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135608
...SDKKAD	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136208
...SDKKAD	493	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136501
...GNAKL	547	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GNAKL	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78577
...GNAKL	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78573
...GNAKL	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78575
...GNAKL	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78578
...GNAKL	547	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78579

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	493	KKAD.\|.DCTI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)