Q15398: Disks large-associated protein 5

General Information

Protein names	- Disks large-associated protein 5 - DAP-5 - Discs large homolog 7 - Disks large-associated protein DLG7 - Hepatoma up-regulated protein - HURP
Gene names	DLGAP5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q15398

5 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Disks large-associated protein 5 - Isoform 3 of Disks large-associated protein 5

Sequence View

        10         20         30         40         50         60
MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV NIPTLEGRIL
        70         80         90        100        110        120
VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE KQLQKLKEQR EKAKRGIFKV
       130        140        150        160        170        180
GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV RITRSKAKDQ MEQTKIDNES DVRAIRPGPR
       190        200        210        220        230        240
QTSEKKVSDK EKKVVQPVMP TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG
       250        260        270        280        290        300
KVPSKGRPAK NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK
       310        320        330        340        350        360
IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV DESQATKEIL
       370        380        390        400        410        420
AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA TTKNLNGLPI KEVPSLERNE
       430        440        450        460        470        480
GRIAQPHHGV PYFRNILQSE TEKLTSHCFE WDRKLELDIP DDAKDLIRTA VGQTRLLMKE
       490        500        510        520        530        540
RFKQFEGLVD DCEYKRGIKE TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN
       550        560        570        580        590        600
MNHNMNKNVF RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI
       610        620        630        640        650        660
PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS RNEMGIPQQT
       670        680        690        700        710        720
TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP DLIEENHVVN KTDLKVDCLS
       730        740        750        760        770        780
SERMSLPLLA GGVADDINTN KKEGISDVVE GMELNSSITS QDVLMSSPEK NTASQNSILE
       790        800        810        820        830        840
EGETKISQSE LFDNKSLTTE CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP

LQPGEF         10         20         30         40         50         60
MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV NIPTLEGRIL
        70         80         90        100        110        120
VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE KQLQKLKEQR EKAKRGIFKV
       130        140        150        160        170        180
GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV RITRSKAKDQ MEQTKIDNES DVRAIRPGPR
       190        200        210        220        230        240
QTSEKKVSDK EKKVVQPVMP TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG
       250        260        270        280        290        300
KVPSKGRPAK NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK
       310        320        330        340        350        360
IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV DESQATKEIL
       370        380        390        400        410        420
AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA TTKNLNGLPI KEVPSLERNE
       430        440        450        460        470        480
GRIAQPHHGV PYFRNILQSE TEKLTSHCFE WDRKLELDIP DDAKDLIRTA VGQTRLLMKE
       490        500        510        520        530        540
RFKQFEGLVD DCEYKRGIKE TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN
       550        560        570        580        590        600
MNHNMNKNVF RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI
       610        620        630        640        650        660
PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS RNEMGIPQQT
       670        680        690        700        710        720
TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP DLIEENHVVN KTDLKVDCLS
       730        740        750        760        770        780
SERMSLPLLA GGVADDINTN KKEGISDVVE GMELNSSITS QDVLMSSPEK NTASQNSILE
       790        800        810        820        830        840
EGETKISQSE LFDNKSLTTE CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP

LQPGEF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q15398-1-unknown	MSSSHF...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q15398-1-unknown	MSSSHF...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt72912
Q15398-407-unknown	GLPIKE...	407	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167421
Q15398-407-	GLPIKE...	407		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q15398-407-	GLPIKE...	407		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q15398-407-	GLPIKE...	407		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q15398-729-unknown	LAGGVA...	729	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4094
Q15398-729-unknown	LAGGVA...	729	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156133
Q15398-731-unknown	GGVADD...	731	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6474
Q15398-731-unknown	GGVADD...	731	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156139

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MSLPLL	728	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4094
...MSLPLL	728	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139597
...LPLLAG	730	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6474
...LPLLAG	730	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139603
...QPGEF	846	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	728	LPLL.\|.LAGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	730	LLAG.\|.GGVA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)