P31943: Heterogeneous nuclear ribonucleoprotein H

General Information

Protein names	- Heterogeneous nuclear ribonucleoprotein H - hnRNP H - Heterogeneous nuclear ribonucleoprotein H, N-terminally processed
Gene names	HNRNPH1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P31943

30 N-termini

22 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE GRPSGEAFVE
        70         80         90        100        110        120
LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT GPNSPDTAND GFVRLRGLPF
       130        140        150        160        170        180
GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY
       190        200        210        220        230        240
IEIFKSSRAE VRTHYDPPRK LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY
       250        260        270        280        290        300
GGYDDYNGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
       310        320        330        340        350        360
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA NMQHRYVELF
       370        380        390        400        410        420
LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY
       430        440
GGGYGGQSSM SGYDQVLQEN SSDFQSNIA

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

30 N-termini - 22 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P31943-1-Acetylation	MMLGTE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31943-1-Acetylation	MMLGTE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P31943-1-Acetylation	MMLGTE...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P31943-2-Acetylation	MLGTEG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P31943-2-Acetylation	MLGTEG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P31943-2-Acetylation	MLGTEG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P31943-2-Acetylation	MLGTEG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P31943-2-Acetylation	MLGTEG...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P31943-2-	MLGTEG...	2			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-2-unknown	MLGTEG...	2			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P31943-2-unknown	MLGTEG...	2			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P31943-4-unknown	GTEGGE...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7435
P31943-5-unknown	TEGGEG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7436
P31943-5-unknown	TEGGEG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5795
P31943-5-unknown	TEGGEG...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3770
P31943-78-unknown	MGHRYV...	78		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000430156
P31943-95-unknown	WVLKHT...	95		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11441
P31943-95-	WVLKHT...	95			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-95-	WVLKHT...	95			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P31943-95-	WVLKHT...	95			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-95-	WVLKHT...	95			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31943-95-	WVLKHT...	95			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-96-	VLKHTG...	96			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-99-	HTGPNS...	99			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-99-	HTGPNS...	99			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31943-99-	HTGPNS...	99			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-107-	TANDGF...	107			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-140-	GITLPV...	140			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-140-	GITLPV...	140			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-151-	STGEAF...	151			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-187-unknown	SRAEVR...	187		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000429270
P31943-245-unknown	DYNGYN...	245		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000429481
P31943-248-	GYNDGY...	248			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-248-	GYNDGY...	248			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-248-	GYNDGY...	248			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P31943-248-	GYNDGY...	248			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-252-unknown	GYGFGS...	252		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1216
P31943-252-	GYGFGS...	252			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P31943-252-	GYGFGS...	252			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-252-	GYGFGS...	252			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P31943-252-	GYGFGS...	252			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-271-unknown	MSDHRY...	271		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000444220
P31943-277-unknown	GDGGST...	277			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P31943-308-	FFSPLN...	308			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-308-	FFSPLN...	308			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-308-	FFSPLN...	308			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P31943-308-	FFSPLN...	308			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P31943-308-	FFSPLN...	308			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-325-unknown	GRVTGE...	325		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11442
P31943-341-	AVAAMS...	341			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P31943-341-	AVAAMS...	341			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-341-	AVAAMS...	341			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-344-unknown	AMSKDK...	344		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7437
P31943-361-	LNSTAG...	361			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P31943-361-unknown	LNSTAG...	361			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P31943-363-	STAGAS...	363			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P31943-363-	STAGAS...	363			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P31943-363-	STAGAS...	363			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P31943-363-unknown	STAGAS...	363		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7438
P31943-363-unknown	STAGAS...	363		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5796
P31943-364-unknown	TAGASG...	364		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7439

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ADEVQR	28	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429179
...FIYTRE	49	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426726
...HRYVEV	84	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000425343
...NVEMDW	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11441
...GFVRLR	115	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429661
...EIVQFF	130	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000421695
...FASQEI	163	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000426518
...IAEKAL	168	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427388
...KERIGH	177	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430156
...AMQRPG	207	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430970
...GPYDRP	212	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000424087
...YDRPGA	214	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427986
...NGYNDG	251	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1216
...PYRATE	301	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000427408
...EIGPDG	324	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11442
...EDAVAA	343	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7437
...ELFLNS	362	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7438
...ELFLNS	362	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5796
...LFLNST	363	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7439
...MMGGMG	400	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429270
...GGMGLS	402	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428620
...YGGQSS	428	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430445
...QSNIA	449	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	3	MMLG.\|.GTEG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	4	MLGT.\|.TEGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	4	MLGT.\|.TEGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	4	MLGT.\|.TEGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	94	EMDW.\|.WVLK	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
CASP1_HUMAN	251	YNDG.\|.GYGF	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
GRAB_HUMAN	324	GPDG.\|.GRVT	inferred from experiment	unknown	MEROPS	Craik CS	Loeb CR et al.:Granzyme B proteolyzes receptor... (S01.010)	16798735,
CATS_HUMAN	343	AVAA.\|.AMSK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	362	FLNS.\|.STAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	362	FLNS.\|.STAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	363	LNST.\|.TAGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)