O95602: DNA-directed RNA polymerase I subunit RPA1

General Information

Protein names	- DNA-directed RNA polymerase I subunit RPA1 - RNA polymerase I subunit A1 - 2.7.7.6 - A190 - DNA-directed RNA polymerase I largest subunit - DNA-directed RNA polymerase I subunit A - RNA polymerase I 194 kDa subunit - RPA194
Gene names	POLR1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O95602

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLISKNMPWR RLQGISFGMY SAEELKKLSV KSITNPRYLD SLGNPSANGL YDLALGPADS
        70         80         90        100        110        120
KEVCSTCVQD FSNCSGHLGH IELPLTVYNP LLFDKLYLLL RGSCLNCHML TCPRAVIHLL
       130        140        150        160        170        180
LCQLRVLEVG ALQAVYELER ILNRFLEENP DPSASEIREE LEQYTTEIVQ NNLLGSQGAH
       190        200        210        220        230        240
VKNVCESKSK LIALFWKAHM NAKRCPHCKT GRSVVRKEHN SKLTITFPAM VHRTAGQKDS
       250        260        270        280        290        300
EPLGIEEAQI GKRGYLTPTS AREHLSALWK NEGFFLNYLF SGMDDDGMES RFNPSVFFLD
       310        320        330        340        350        360
FLVVPPSRYR PVSRLGDQMF TNGQTVNLQA VMKDVVLIRK LLALMAQEQK LPEEVATPTT
       370        380        390        400        410        420
DEEKDSLIAI DRSFLSTLPG QSLIDKLYNI WIRLQSHVNI VFDSEMDKLM MDKYPGIRQI
       430        440        450        460        470        480
LEKKEGLFRK HMMGKRVDYA ARSVICPDMY INTNEIGIPM VFATKLTYPQ PVTPWNVQEL
       490        500        510        520        530        540
RQAVINGPNV HPGASMVINE DGSRTALSAV DMTQREAVAK QLLTPATGAP KPQGTKIVCR
       550        560        570        580        590        600
HVKNGDILLL NRQPTLHRPS IQAHRARILP EEKVLRLHYA NCKAYNADFD GDEMNAHFPQ
       610        620        630        640        650        660
SELGRAEAYV LACTDQQYLV PKDGQPLAGL IQDHMVSGAS MTTRGCFFTR EHYMELVYRG
       670        680        690        700        710        720
LTDKVGRVKL LSPSILKPFP LWTGKQVVST LLINIIPEDH IPLNLSGKAK ITGKAWVKET
       730        740        750        760        770        780
PRSVPGFNPD SMCESQVIIR EGELLCGVLD KAHYGSSAYG LVHCCYEIYG GETSGKVLTC
       790        800        810        820        830        840
LARLFTAYLQ LYRGFTLGVE DILVKPKADV KRQRIIEEST HCGPQAVRAA LNLPEAASYD
       850        860        870        880        890        900
EVRGKWQDAH LGKDQRDFNM IDLKFKEEVN HYSNEINKAC MPFGLHRQFP ENSLQMMVQS
       910        920        930        940        950        960
GAKGSTVNTM QISCLLGQIE LEGRRPPLMA SGKSLPCFEP YEFTPRAGGF VTGRFLTGIK
       970        980        990       1000       1010       1020
PPEFFFHCMA GREGLVDTAV KTSRSGYLQR CIIKHLEGLV VQYDLTVRDS DGSVVQFLYG
      1030       1040       1050       1060       1070       1080
EDGLDIPKTQ FLQPKQFPFL ASNYEVIMKS QHLHEVLSRA DPKKALHHFR AIKKWQSKHP
      1090       1100       1110       1120       1130       1140
NTLLRRGAFL SYSQKIQEAV KALKLESENR NGRSPGTQEM LRMWYELDEE SRRKYQKKAA
      1150       1160       1170       1180       1190       1200
ACPDPSLSVW RPDIYFASVS ETFETKVDDY SQEWAAQTEK SYEKSELSLD RLRTLLQLKW
      1210       1220       1230       1240       1250       1260
QRSLCEPGEA VGLLAAQSIG EPSTQMTLNT FHFAGRGEMN VTLGIPRLRE ILMVASANIK
      1270       1280       1290       1300       1310       1320
TPMMSVPVLN TKKALKRVKS LKKQLTRVCL GEVLQKIDVQ ESFCMEEKQN KFQVYQLRFQ
      1330       1340       1350       1360       1370       1380
FLPHAYYQQE KCLRPEDILR FMETRFFKLL MESIKKKNNK ASAFRNVNTR RATQRDLDNA
      1390       1400       1410       1420       1430       1440
GELGRSRGEQ EGDEEEEGHI VDAEAEEGDA DASDAKRKEK QEEEVDYESE EEEEREGEEN
      1450       1460       1470       1480       1490       1500
DDEDMQEERN PHREGARKTQ EQDEEVGLGT EEDPSLPALL TQPRKPTHSQ EPQGPEAMER
      1510       1520       1530       1540       1550       1560
RVQAVREIHP FIDDYQYDTE ESLWCQVTVK LPLMKINFDM SSLVVSLAHG AVIYATKGIT
      1570       1580       1590       1600       1610       1620
RCLLNETTNN KNEKELVLNT EGINLPELFK YAEVLDLRRL YSNDIHAIAN TYGIEAALRV
      1630       1640       1650       1660       1670       1680
IEKEIKDVFA VYGIAVDPRH LSLVADYMCF EGVYKPLNRF GIRSNSSPLQ QMTFETSFQF
      1690       1700       1710       1720
LKQATMLGSH DELRSPSACL VVGKVVRGGT GLFELKQPLR

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O95602-1-acetylation	MLISKN...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O95602-1-unknown	MLISKN...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O95602-449-unknown	MYINTN...	449		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11023
O95602-508-unknown	SAVDMT...	508		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13877
O95602-524-unknown	TPATGA...	524		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5292
O95602-1405-unknown	AEEGDA...	1405		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11024

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VICPDM	448	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11023
...SRTALS	507	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13877
...AKQLLT	523	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5292
...IVDAEA	1404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11024
...KQPLR	1720	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	448	CPDM.\|.MYIN	inferred from experiment	unknown	MEROPS	Rosen A	Casciola-Rosen L et al.:Cleavage by granzyme B is stron... (S01.010)	10499920,
GRAM_HUMAN	507	TALS.\|.SAVD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	523	QLLT.\|.TPAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	1404	DAEA.\|.AEEG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)