Q7L2H7: Eukaryotic translation initiation factor 3 subunit M {ECO:0000255|HAMAP-Rule:MF_03012}

General Information

Protein names	- Eukaryotic translation initiation factor 3 subunit M {ECO:0000255\|HAMAP-Rule:MF_03012} - eIF3m {ECO:0000255\|HAMAP-Rule:MF_03012} - Fetal lung protein B5 - hFL-B5 - PCI domain-containing protein 1
Gene names	EIF3M
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q7L2H7

10 N-termini

8 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSVPAFIDIS EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV
        70         80         90        100        110        120
ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERPS LRLQLLSNLF HGMDKNTPVR
       130        140        150        160        170        180
YTVYCSLIKV AASCGAIQYI PTELDQVRKW ISDWNLTTEK KHTLLRLLYE ALVDCKKSDA
       190        200        210        220        230        240
ASKVMVELLG SYTEDNASQA RVDAHRCIVR ALKDPNAFLF DHLLTLKPVK FLEGELIHDL
       250        260        270        280        290        300
LTIFVSAKLA SYVKFYQNNK DFIDSLGLLH EQNMAKMRLL TFMGMAVENK EISFDTMQQE
       310        320        330        340        350        360
LQIGADDVEA FVIDAVRTKM VYCKIDQTQR KVVVSHSTHR TFGKQQWQQL YDTLNAWKQN
       370
LNKVKNSLLS LSDT

Isoforms

- Isoform 2 of Eukaryotic translation initiation factor 3 subunit M

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 8 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q7L2H7-2-unknown	MSVPAF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7L2H7-2-	SVPAFI...	2			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q7L2H7-2-Acetylation	SVPAFI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q7L2H7-2-Acetylation	SVPAFI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q7L2H7-2-Acetylation	SVPAFI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q7L2H7-2-Acetylation	SVPAFI...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q7L2H7-64-unknown	MNSVVS...	64		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000319910
Q7L2H7-64-unknown	MNSVVS...	64		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432891
Q7L2H7-78-	KQEALI...	78			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q7L2H7-160-unknown	KKHTLL...	160		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000432139
Q7L2H7-188-unknown	LLGSYT...	188		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4146
Q7L2H7-190-unknown	GSYTED...	190		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7928
Q7L2H7-191-unknown	SYTEDN...	191		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6563
Q7L2H7-307-unknown	DVEAFV...	307		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12668

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KHTLLR	165	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432891
...KVMVEL	187	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4146
...MVELLG	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7928
...VELLGS	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6563
...ASYVKF	254	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000319910
...QIGADD	306	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12668
...KVKNSL	367	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432139
...SLSDT	374	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATB_HUMAN	187	MVEL.\|.LLGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	189	ELLG.\|.GSYT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	190	LLGS.\|.SYTE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	306	GADD.\|.DVEA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)