Q86V81: THO complex subunit 4

General Information

Protein names	- THO complex subunit 4 - Tho4 - Ally of AML-1 and LEF-1 - Aly/REF export factor - Transcriptional coactivator Aly/REF - bZIP-enhancing factor BEF
Gene names	ALYREF
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q86V81

22 N-termini

14 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADKMDMSLD DIIKLNRSQR GGRGGGRGRG RAGSQGGRGG GAQAAARVNR GGGPIRNRPA
        70         80         90        100        110        120
IARGAAGGGG RNRPAPYSRP KQLPDKWQHD LFDSGFGGGA GVETGGKLLV SNLDFGVSDA
       130        140        150        160        170        180
DIQELFAEFG TLKKAAVHYD RSGRSLGTAD VHFERKADAL KAMKQYNGVP LDGRPMNIQL
       190        200        210        220        230        240
VTSQIDAQRR PAQSVNRGGM TRNRGAGGFG GGGGTRRGTR GGARGRGRGA GRNSKQQLSA
       250
EELDAQLDAY NARMDTS

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

22 N-termini - 14 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q86V81-2-unknown	MADKMD...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86V81-2-Acetylation	ADKMDM...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q86V81-2-Acetylation	ADKMDM...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q86V81-2-Acetylation	ADKMDM...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q86V81-4-unknown	KMDMSL...	4		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12761
Q86V81-8-	SLDDII...	8			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86V81-8-	SLDDII...	8			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86V81-8-unknown	SLDDII...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14690
Q86V81-11-unknown	DIIKLN...	11		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12762
Q86V81-91-unknown	LFDSGF...	91		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1318
Q86V81-93-	DSGFGG...	93			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86V81-93-unknown	DSGFGG...	93		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18023
Q86V81-93-unknown	DSGFGG...	93			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86V81-94-unknown	SGFGGG...	94		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7935
Q86V81-94-unknown	SGFGGG...	94			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q86V81-94-	SGFGGG...	94			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q86V81-94-	SGFGGG...	94			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_CD95	23264352
Q86V81-94-	SGFGGG...	94			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q86V81-94-	SGFGGG...	94			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86V81-94-	SGFGGG...	94			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q86V81-96-unknown	FGGGAG...	96		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4150
Q86V81-98-unknown	GGAGVE...	98		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7936
Q86V81-145-	SLGTAD...	145			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q86V81-145-	SLGTAD...	145			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q86V81-148-unknown	TADVHF...	148		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7937
Q86V81-148-unknown	TADVHF...	148		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6580
Q86V81-168-	GVPLDG...	168			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q86V81-168-	GVPLDG...	168			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q86V81-208-unknown	GFGGGG...	208		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4151
Q86V81-233-	NSKQQL...	233			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q86V81-239-unknown	SAEELD...	239		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14691
Q86V81-242-unknown	ELDAQL...	242		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14692
Q86V81-242-unknown	ELDAQL...	242		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12763
Q86V81-244-unknown	DAQLDA...	244		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14693
Q86V81-249-unknown	AYNARM...	249		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12764

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DKMDMS	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14690
...DMSLDD	10	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12762
...KWQHDL	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1318
...QHDLFD	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18023
...HDLFDS	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7935
...LFDSGF	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4150
...DSGFGG	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7936
...GRSLGT	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7937
...GRSLGT	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6580
...NRGAGG	207	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4151
...SKQQLS	238	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14691
...QLSAEE	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14692
...QLSAEE	241	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12763
...SAEELD	243	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14693
...DAQLDA	248	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12764
...RMDTS	257	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	3	MADK.\|.KMDM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	7	MDMS.\|.SLDD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	10	SLDD.\|.DIIK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP1_HUMAN	90	QHDL.\|.LFDS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
MEP1A_HUMAN	92	DLFD.\|.DSGF	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	93	LFDS.\|.SGFG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	95	DSGF.\|.FGGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	97	GFGG.\|.GGAG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	147	SLGT.\|.TADV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	147	SLGT.\|.TADV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	207	GAGG.\|.GFGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	238	QQLS.\|.SAEE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	241	SAEE.\|.ELDA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	241	SAEE.\|.ELDA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	243	EELD.\|.DAQL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	248	QLDA.\|.AYNA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)