Q32MZ4: Leucine-rich repeat flightless-interacting protein 1

General Information

Protein names	- Leucine-rich repeat flightless-interacting protein 1 - LRR FLII-interacting protein 1 - GC-binding factor 2 - TAR RNA-interacting protein
Gene names	LRRFIP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q32MZ4

30 N-termini

10 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Leucine-rich repeat flightless-interacting protein 1 - Isoform 3 of Leucine-rich repeat flightless-interacting protein 1 - Isoform 4 of Leucine-rich repeat flightless-interacting protein 1

Sequence View

        10         20         30         40         50         60
MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK EEDSERYSRR
        70         80         90        100        110        120
SRRNTSASDE DERMSVGSRG SLRVEERPEK DFTEKGSRNM PGLSAATLAS LGGTSSRRGS
       130        140        150        160        170        180
GDTSISIDTE ASIREIKELN ELKDQIQDVE GKYMQGLKEM KDSLAEVEEK YKKAMVSNAQ
       190        200        210        220        230        240
LDNEKTNFMY QVDTLKDMLL ELEEQLAESR RQYEEKNKEF EREKHAHSIL QFQFAEVKEA
       250        260        270        280        290        300
LKQREEMLEK HGIILNSEIA TNGETSDTLN NVGYQGPTKM TKEELNALKS TGDGTLGRAS
       310        320        330        340        350        360
EVEVKNEIVA NVGKREILHN TEKEQHTEDT VKDCVDIEVF PAGENTEDQK SSEDTAPFLG
       370        380        390        400        410        420
TLAGATYEEQ VQSQILESSS LPENTVQVES NEVMGAPDDR TRTPLEPSNC WSDLDGGNHT
       430        440        450        460        470        480
ENVGEAAVTQ VEEQAGTVAS CPLGHSDDTV YHDDKCMVEV PQELETSTGH SLEKEFTNQE
       490        500        510        520        530        540
AAEPKEVPAH STEVGRDHNE EEGEETGLRD EKPIKTEVPG SPAGTEGNCQ EATGPSTVDT
       550        560        570        580        590        600
QNEPLDMKEP DEEKSDQQGE ALDSSQKKTK NKKKKNKKKK SPVPVETLKD VKKELTYQNT
       610        620        630        640        650        660
DLSEIKEEEQ VKSTDRKSAV EAQNEVTENP KQKIAAESSE NVDCPENPKI KLDGKLDQEG
       670        680        690        700        710        720
DDVQTAAEEV LADGDTLDFE DDTVQSSGPR AGGEELDEGV AKDNAKIDGA TQSSPAEPKS
       730        740        750        760        770        780
EDADRCTLPE HESPSQDISD ACEAESTERC EMSEHPSQTV RKALDSNSLE NDDLSAPGRE
       790        800
PGHFNPESRE DTRGGNEKGK SKEDCTMS         10         20         30         40         50         60
MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK EEDSERYSRR
        70         80         90        100        110        120
SRRNTSASDE DERMSVGSRG SLRVEERPEK DFTEKGSRNM PGLSAATLAS LGGTSSRRGS
       130        140        150        160        170        180
GDTSISIDTE ASIREIKELN ELKDQIQDVE GKYMQGLKEM KDSLAEVEEK YKKAMVSNAQ
       190        200        210        220        230        240
LDNEKTNFMY QVDTLKDMLL ELEEQLAESR RQYEEKNKEF EREKHAHSIL QFQFAEVKEA
       250        260        270        280        290        300
LKQREEMLEK HGIILNSEIA TNGETSDTLN NVGYQGPTKM TKEELNALKS TGDGTLGRAS
       310        320        330        340        350        360
EVEVKNEIVA NVGKREILHN TEKEQHTEDT VKDCVDIEVF PAGENTEDQK SSEDTAPFLG
       370        380        390        400        410        420
TLAGATYEEQ VQSQILESSS LPENTVQVES NEVMGAPDDR TRTPLEPSNC WSDLDGGNHT
       430        440        450        460        470        480
ENVGEAAVTQ VEEQAGTVAS CPLGHSDDTV YHDDKCMVEV PQELETSTGH SLEKEFTNQE
       490        500        510        520        530        540
AAEPKEVPAH STEVGRDHNE EEGEETGLRD EKPIKTEVPG SPAGTEGNCQ EATGPSTVDT
       550        560        570        580        590        600
QNEPLDMKEP DEEKSDQQGE ALDSSQKKTK NKKKKNKKKK SPVPVETLKD VKKELTYQNT
       610        620        630        640        650        660
DLSEIKEEEQ VKSTDRKSAV EAQNEVTENP KQKIAAESSE NVDCPENPKI KLDGKLDQEG
       670        680        690        700        710        720
DDVQTAAEEV LADGDTLDFE DDTVQSSGPR AGGEELDEGV AKDNAKIDGA TQSSPAEPKS
       730        740        750        760        770        780
EDADRCTLPE HESPSQDISD ACEAESTERC EMSEHPSQTV RKALDSNSLE NDDLSAPGRE
       790        800
PGHFNPESRE DTRGGNEKGK SKEDCTMS         10         20         30         40         50         60
MTSPAAAQSR EIDCLSPEAQ KLAEARLAAK RAARAEAREI RMKELERQQK EEDSERYSRR
        70         80         90        100        110        120
SRRNTSASDE DERMSVGSRG SLRVEERPEK DFTEKGSRNM PGLSAATLAS LGGTSSRRGS
       130        140        150        160        170        180
GDTSISIDTE ASIREIKELN ELKDQIQDVE GKYMQGLKEM KDSLAEVEEK YKKAMVSNAQ
       190        200        210        220        230        240
LDNEKTNFMY QVDTLKDMLL ELEEQLAESR RQYEEKNKEF EREKHAHSIL QFQFAEVKEA
       250        260        270        280        290        300
LKQREEMLEK HGIILNSEIA TNGETSDTLN NVGYQGPTKM TKEELNALKS TGDGTLGRAS
       310        320        330        340        350        360
EVEVKNEIVA NVGKREILHN TEKEQHTEDT VKDCVDIEVF PAGENTEDQK SSEDTAPFLG
       370        380        390        400        410        420
TLAGATYEEQ VQSQILESSS LPENTVQVES NEVMGAPDDR TRTPLEPSNC WSDLDGGNHT
       430        440        450        460        470        480
ENVGEAAVTQ VEEQAGTVAS CPLGHSDDTV YHDDKCMVEV PQELETSTGH SLEKEFTNQE
       490        500        510        520        530        540
AAEPKEVPAH STEVGRDHNE EEGEETGLRD EKPIKTEVPG SPAGTEGNCQ EATGPSTVDT
       550        560        570        580        590        600
QNEPLDMKEP DEEKSDQQGE ALDSSQKKTK NKKKKNKKKK SPVPVETLKD VKKELTYQNT
       610        620        630        640        650        660
DLSEIKEEEQ VKSTDRKSAV EAQNEVTENP KQKIAAESSE NVDCPENPKI KLDGKLDQEG
       670        680        690        700        710        720
DDVQTAAEEV LADGDTLDFE DDTVQSSGPR AGGEELDEGV AKDNAKIDGA TQSSPAEPKS
       730        740        750        760        770        780
EDADRCTLPE HESPSQDISD ACEAESTERC EMSEHPSQTV RKALDSNSLE NDDLSAPGRE
       790        800
PGHFNPESRE DTRGGNEKGK SKEDCTMS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

30 N-termini - 10 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q32MZ4-2-unknown	MTSPAA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q32MZ4-1-acetylation	MTSPAA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q32MZ4-1-acetylation	MTSPAA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178855
Q32MZ4-1-acetylation	MTSPAA...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178856
Q32MZ4-1-unknown	MTSPAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79976
Q32MZ4-1-unknown	MTSPAA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79977
Q32MZ4-2-Acetylation	TSPAAA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q32MZ4-2-Acetylation	TSPAAA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q32MZ4-2-Acetylation	TSPAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110224
Q32MZ4-2-Acetylation	TSPAAA...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110225
Q32MZ4-105-	AATLAS...	105			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q32MZ4-105-	AATLAS...	105			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q32MZ4-105-unknown	AATLAS...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167220
Q32MZ4-105-unknown	AATLAS...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167221
Q32MZ4-105-unknown	AATLAS...	105		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167219
Q32MZ4-287-	ALKSTG...	287			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q32MZ4-287-unknown	ALKSTG...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167223
Q32MZ4-287-unknown	ALKSTG...	287		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167224
Q32MZ4-339-unknown	VFPAGE...	339		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175035
Q32MZ4-339-unknown	VFPAGE...	339		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175036
Q32MZ4-339-	VFPAGE...	339			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q32MZ4-378-unknown	SSSLPE...	378		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175029
Q32MZ4-378-unknown	SSSLPE...	378		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175030
Q32MZ4-378-	SSSLPE...	378			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q32MZ4-380-	SLPENT...	380			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q32MZ4-380-unknown	SLPENT...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167226
Q32MZ4-380-unknown	SLPENT...	380		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167227
Q32MZ4-390-unknown	SNEVMG...	390		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12415
Q32MZ4-390-unknown	SNEVMG...	390		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150602
Q32MZ4-390-unknown	SNEVMG...	390		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151330
Q32MZ4-416-	GGNHTE...	416			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q32MZ4-416-unknown	GGNHTE...	416		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172292
Q32MZ4-416-unknown	GGNHTE...	416		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172293
Q32MZ4-419-unknown	HTENVG...	419		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175032
Q32MZ4-419-unknown	HTENVG...	419		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175033
Q32MZ4-419-	HTENVG...	419			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q32MZ4-427-	AVTQVE...	427			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q32MZ4-427-	AVTQVE...	427			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q32MZ4-427-unknown	AVTQVE...	427		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172295
Q32MZ4-427-unknown	AVTQVE...	427		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt172296
Q32MZ4-445-unknown	HSDDTV...	445		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6501
Q32MZ4-445-unknown	HSDDTV...	445		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151819
Q32MZ4-445-unknown	HSDDTV...	445		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152352
Q32MZ4-457-	MVEVPQ...	457			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q32MZ4-457-unknown	MVEVPQ...	457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175026
Q32MZ4-457-unknown	MVEVPQ...	457		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt175027
Q32MZ4-596-unknown	TYQNTD...	596		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14548
Q32MZ4-596-unknown	TYQNTD...	596		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153877
Q32MZ4-596-unknown	TYQNTD...	596		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154240
Q32MZ4-638-unknown	SSENVD...	638		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12418
Q32MZ4-638-unknown	SSENVD...	638		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154356
Q32MZ4-638-unknown	SSENVD...	638		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154825
Q32MZ4-674-unknown	GDTLDF...	674		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12421
Q32MZ4-674-unknown	GDTLDF...	674		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3222
Q32MZ4-674-unknown	GDTLDF...	674		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154891
Q32MZ4-674-unknown	GDTLDF...	674		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155314
Q32MZ4-676-unknown	TLDFED...	676		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12424
Q32MZ4-676-unknown	TLDFED...	676		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154918
Q32MZ4-676-unknown	TLDFED...	676		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155343
Q32MZ4-738-unknown	ISDACE...	738		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12427
Q32MZ4-738-unknown	ISDACE...	738		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155676
Q32MZ4-738-unknown	ISDACE...	738		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155986
Q32MZ4-773-unknown	DLSAPG...	773		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12430
Q32MZ4-773-unknown	DLSAPG...	773		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156007
Q32MZ4-773-unknown	DLSAPG...	773		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156267

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...TVQVES	389	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12415
...TVQVES	389	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134000
...TVQVES	389	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134732
...SCPLGH	444	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6501
...SCPLGH	444	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135223
...SCPLGH	444	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt135763
...VKKELT	595	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14548
...VKKELT	595	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137299
...VKKELT	595	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137661
...KIAAES	637	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12418
...KIAAES	637	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt137777
...KIAAES	637	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138252
...EVLADG	673	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12421
...EVLADG	673	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3222
...EVLADG	673	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138318
...EVLADG	673	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138747
...LADGDT	675	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12424
...LADGDT	675	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138345
...LADGDT	675	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt138776
...SPSQDI	737	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12427
...SPSQDI	737	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139119
...SPSQDI	737	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139445
...SLENDD	772	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12430
...SLENDD	772	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139467
...SLENDD	772	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt139736
...DCTMS	808	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DCTMS	808	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt75595
...DCTMS	808	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt75594
...DCTMS	808		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DCTMS	808		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DCTMS	808		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DCTMS	808		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	389	QVES.\|.SNEV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	444	PLGH.\|.HSDD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	595	KELT.\|.TYQN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	637	AAES.\|.SSEN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	673	LADG.\|.GDTL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASPE_HUMAN	673	LADG.\|.GDTL	inferred from experiment	unknown	MEROPS		Merops CASPE_HUMAN -> LRRF1_HUMAN @673
GRAB_HUMAN	675	DGDT.\|.TLDF	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	737	SQDI.\|.ISDA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	772	ENDD.\|.DLSA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)