Q9BQ69: ADP-ribose glycohydrolase MACROD1 {ECO:0000305}

General Information

Protein names	- ADP-ribose glycohydrolase MACROD1 {ECO:0000305} - MACRO domain-containing protein 1 {ECO:0000303\|PubMed:23474712} - O-acetyl-ADP-ribose deacetylase MACROD1 - 3.5.1.- {ECO:0000305\|PubMed:21257746} - Protein LRP16 - Protein ADP-ribosylaspartate] hydrolase MACROD1 {ECO:0000305} - 3.2.2.- {ECO:0000269\|PubMed:23474714} - Protein ADP-ribosylglutamate] hydrolase MACROD1 {ECO:0000305} - 3.2.2.- {ECO:0000269\|PubMed:23474712, ECO:0000269\|PubMed:23474714}
Gene names	MACROD1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BQ69

4 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSLQSRLSGR LAQLRAAGQL LVPPRPRPGH LAGATRTRSS TCGPPAFLGV FGRRARTSAG
        70         80         90        100        110        120
VGAWGAAAVG RTAGVRTWAP LAMAAKVDLS TSTDWKEAKS FLKGLSDKQR EEHYFCKDFV
       130        140        150        160        170        180
RLKKIPTWKE MAKGVAVKVE EPRYKKDKQL NEKISLLRSD ITKLEVDAIV NAANSSLLGG
       190        200        210        220        230        240
GGVDGCIHRA AGPLLTDECR TLQSCKTGKA KITGGYRLPA KYVIHTVGPI AYGEPSASQA
       250        260        270        280        290        300
AELRSCYLSS LDLLLEHRLR SVAFPCISTG VFGYPCEAAA EIVLATLREW LEQHKDKVDR
       310        320
LIICVFLEKD EDIYRSRLPH YFPVA

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BQ69-1-unknown	MSLQSR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BQ69-84-	AAKVDL...	84		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BQ69-84-	AAKVDL...	84		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9BQ69-84-	AAKVDL...	84		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9BQ69-168-unknown	AIVNAA...	168	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13160
Q9BQ69-180-unknown	GGGVDG...	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6724
Q9BQ69-180-unknown	GGGVDG...	180	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8048

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KLEVDA	167	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC13160
...SSLLGG	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6724
...SSLLGG	179	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8048
...YFPVA	325	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	167	EVDA.\|.AIVN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	179	LLGG.\|.GGGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	179	LLGG.\|.GGGV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)