Q07955: Serine/arginine-rich splicing factor 1

General Information

Protein names	- Serine/arginine-rich splicing factor 1 - Alternative-splicing factor 1 - ASF-1 - Splicing factor, arginine/serine-rich 1 - pre-mRNA-splicing factor SF2, P33 subunit
Gene names	SRSF1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07955

10 N-termini

7 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform ASF-2 of Serine/arginine-rich splicing factor 1 - Isoform ASF-3 of Serine/arginine-rich splicing factor 1

Sequence View

        10         20         30         40         50         60
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE
        70         80         90        100        110        120
FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE
       130        140        150        160        170        180
NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF
       190        200        210        220        230        240
RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR

HSRSRSRT         10         20         30         40         50         60
MSGGGVIRGP AGNNDCRIYV GNLPPDIRTK DIEDVFYKYG AIRDIDLKNR RGGPPFAFVE
        70         80         90        100        110        120
FEDPRDAEDA VYGRDGYDYD GYRLRVEFPR SGRGTGRGGG GGGGGGAPRG RYGPPSRRSE
       130        140        150        160        170        180
NRVVVSGLPP SGSWQDLKDH MREAGDVCYA DVYRDGTGVV EFVRKEDMTY AVRKLDNTKF
       190        200        210        220        230        240
RSHEGETAYI RVKVDGPRSP SYGRSRSRSR SRSRSRSRSN SRSRSYSPRR SRGSPRYSPR

HSRSRSRT

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Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

10 N-termini - 7 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q07955-2-unknown	MSGGGV...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q07955-1-unknown	MSGGGV...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90732
Q07955-1-unknown	MSGGGV...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt90733
Q07955-2-Acetylation	SGGGVI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q07955-2-Acetylation	SGGGVI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110045
Q07955-2-Acetylation	SGGGVI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110046
Q07955-26-unknown	DIRTKD...	26		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q07955-26-unknown	DIRTKD...	26		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195410
Q07955-26-unknown	DIRTKD...	26		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195411
Q07955-58-unknown	FVEFED...	58		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6245
Q07955-58-unknown	FVEFED...	58		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139736
Q07955-58-unknown	FVEFED...	58		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139737
Q07955-127-unknown	GLPPSG...	127		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6248
Q07955-127-unknown	GLPPSG...	127		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143776
Q07955-127-unknown	GLPPSG...	127		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt143777
Q07955-140-unknown	HMREAG...	140		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2105
Q07955-140-unknown	HMREAG...	140		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144286
Q07955-140-unknown	HMREAG...	140		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144287
Q07955-152-unknown	VYRDGT...	152		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2108
Q07955-152-unknown	VYRDGT...	152		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144812
Q07955-152-unknown	VYRDGT...	152		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144813
Q07955-156-unknown	GTGVVE...	156		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2111
Q07955-156-unknown	GTGVVE...	156		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144976
Q07955-156-unknown	GTGVVE...	156		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144977
Q07955-177-unknown	NTKFRS...	177		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2114

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GPPFAF	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6245
...GPPFAF	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122835
...GPPFAF	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122836
...RVVVSG	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6248
...RVVVSG	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127018
...RVVVSG	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127019
...QDLKDH	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2105
...QDLKDH	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127545
...QDLKDH	139	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127546
...VCYADV	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2108
...VCYADV	151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128088
...VCYADV	151	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128089
...DVYRDG	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2111
...DVYRDG	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128256
...DVYRDG	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128257
...VRKLDN	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2114
...VRKLDN	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155345
...VRKLDN	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155346
...SRSRT	248	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	57	PFAF.\|.FVEF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	126	VVSG.\|.GLPP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CASP3_HUMAN	139	LKDH.\|.HMRE	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	151	YADV.\|.VYRD	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	155	YRDG.\|.GTGV	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,
CASP3_HUMAN	176	KLDN.\|.NTKF	inferred from experiment	unknown	MEROPS	Rudel T	Thiede B et al.:Predominant identification of R... (C14.003)	11352910,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)