Q12972: Nuclear inhibitor of protein phosphatase 1

General Information

Protein names	- Nuclear inhibitor of protein phosphatase 1 - NIPP-1 - Protein phosphatase 1 regulatory inhibitor subunit 8 - Activator of RNA decay - 3.1.4.- - ARD-1
Gene names	PPP1R8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12972

9 N-termini

3 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Beta of Nuclear inhibitor of protein phosphatase 1 - Isoform Gamma of Nuclear inhibitor of protein phosphatase 1

Sequence View

        10         20         30         40         50         60
MAAAANSGSS LPLFDCPTWA GKPPPGLHLD VVKGDKLIEK LIIDEKKYYL FGRNPDLCDF
        70         80         90        100        110        120
TIDHQSCSRV HAALVYHKHL KRVFLIDLNS THGTFLGHIR LEPHKPQQIP IDSTVSFGAS
       130        140        150        160        170        180
TRAYTLREKP QTLPSAVKGD EKMGGEDDEL KGLLGLPEEE TELDNLTEFN TAHNKRISTL
       190        200        210        220        230        240
TIEEGNLDIQ RPKRKRKNSR VTFSEDDEII NPEDVDPSVG RFRNMVQTAV VPVKKKRVEG
       250        260        270        280        290        300
PGSLGLEESG SRRMQNFAFS GGLYGGLPPT HSEAGSQPHG IHGTALIGGL PMPYPNLAPD
       310        320        330        340        350
VDLTPVVPSA VNMNPAPNPA VYNPEAVNEP KKKKYAKEAW PGKKPTPSLL I         10         20         30         40         50         60
MAAAANSGSS LPLFDCPTWA GKPPPGLHLD VVKGDKLIEK LIIDEKKYYL FGRNPDLCDF
        70         80         90        100        110        120
TIDHQSCSRV HAALVYHKHL KRVFLIDLNS THGTFLGHIR LEPHKPQQIP IDSTVSFGAS
       130        140        150        160        170        180
TRAYTLREKP QTLPSAVKGD EKMGGEDDEL KGLLGLPEEE TELDNLTEFN TAHNKRISTL
       190        200        210        220        230        240
TIEEGNLDIQ RPKRKRKNSR VTFSEDDEII NPEDVDPSVG RFRNMVQTAV VPVKKKRVEG
       250        260        270        280        290        300
PGSLGLEESG SRRMQNFAFS GGLYGGLPPT HSEAGSQPHG IHGTALIGGL PMPYPNLAPD
       310        320        330        340        350
VDLTPVVPSA VNMNPAPNPA VYNPEAVNEP KKKKYAKEAW PGKKPTPSLL I

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q12972-1-unknown	MAAAAN...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12972-143-unknown	MGGEDD...	143	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85845
Q12972-144-	GGEDDE...	144		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q12972-144-unknown	GGEDDE...	144	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171551
Q12972-207-unknown	DEIINP...	207	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11989
Q12972-207-unknown	DEIINP...	207	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140328
Q12972-225-unknown	MVQTAV...	225	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85846
Q12972-225-unknown	MVQTAV...	225	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100809
Q12972-228-unknown	TAVVPV...	228	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3976
Q12972-228-unknown	TAVVPV...	228	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6304
Q12972-228-unknown	TAVVPV...	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141637
Q12972-228-unknown	TAVVPV...	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196723
Q12972-312-	NMNPAP...	312		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q12972-312-unknown	NMNPAP...	312	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173569
Q12972-312-unknown	NMNPAP...	312	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173570

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TFSEDD	206	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11989
...TFSEDD	206	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123450
...RNMVQT	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3976
...RNMVQT	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6304
...RNMVQT	227	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124816
...PSLLI	351	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSLLI	351	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81464
...PSLLI	351	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81463

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	206	SEDD.\|.DEII	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATB_HUMAN	227	MVQT.\|.TAVV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	227	MVQT.\|.TAVV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)