P26640: Valine--tRNA ligase

General Information

Protein names	- Valine--tRNA ligase - 6.1.1.9 - Protein G7a - Valyl-tRNA synthetase - ValRS
Gene names	VARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P26640

8 N-termini

8 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSTLYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRT PFPPPRLPAL
        70         80         90        100        110        120
EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG
       130        140        150        160        170        180
LRSSAQDPQA VLGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPPA
       190        200        210        220        230        240
RRIWNNVTRW FVTCVRQPEF RAVLGEVVLY SGARPLSHQP GPEAPALPKT AAQLKKEAKK
       250        260        270        280        290        300
REKLEKFQQK QKIQQQQPPP GEKKPKPEKR EKRDPGVITY DLPTPPGEKK DVSGPMPDSY
       310        320        330        340        350        360
SPRYVEAAWY PWWEQQGFFK PEYGRPNVSA ANPRGVFMMC IPPPNVTGSL HLGHALTNAI
       370        380        390        400        410        420
QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK
       430        440        450        460        470        480
EEKGDRIYHQ LKKLGSSLDW DRACFTMDPK LSAAVTEAFV RLHEEGIIYR STRLVNWSCT
       490        500        510        520        530        540
LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KVQGSDSDEE VVVATTRIET
       550        560        570        580        590        600
MLGDVAVAVH PKDTRYQHLK GKNVIHPFLS RSLPIVFDEF VDMDFGTGAV KITPAHDQND
       610        620        630        640        650        660
YEVGQRHGLE AISIMDSRGA LINVPPPFLG LPRFEARKAV LVALKERGLF RGIEDNPMVV
       670        680        690        700        710        720
PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH AWMDNIREWC
       730        740        750        760        770        780
ISRQLWWGHR IPAYFVTVSD PAVPPGEDPD GRYWVSGRNE AEAREKAAKE FGVSPDKISL
       790        800        810        820        830        840
QQDEDVLDTW FSSGLFPLSI LGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL
       850        860        870        880        890        900
TGRLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIYGI SLQGLHNQLL NSNLDPSEVE
       910        920        930        940        950        960
KAKEGQKADF PAGIPECGTD ALRFGLCAYM SQGRDINLDV NRILGYRHFC NKLWNATKFA
       970        980        990       1000       1010       1020
LRGLGKGFVP SPTSQPGGHE SLVDRWIRSR LTEAVRLSNQ GFQAYDFPAV TTAQYSFWLY
      1030       1040       1050       1060       1070       1080
ELCDVYLECL KPVLNGVDQV AAECARQTLY TCLDVGLRLL SPFMPFVTEE LFQRLPRRMP
      1090       1100       1110       1120       1130       1140
QAPPSLCVTP YPEPSECSWK DPEAEAALEL ALSITRAVRS LRADYNLTRI RPDCFLEVAD
      1150       1160       1170       1180       1190       1200
EATGALASAV SGYVQALASA GVVAVLALGA PAPQGCAVAL ASDRCSIHLQ LQGLVDPARE
      1210       1220       1230       1240       1250       1260
LGKLQAKRVE AQRQAQRLRE RRAASGYPVK VPLEVQEADE AKLQQTEAEL RKVDEAIALF

QKML

Isoforms

- Isoform 2 of Valine--tRNA ligase

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 8 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P26640-2-unknown	MSTLYV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26640-2-Acetylation	STLYVS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P26640-2-Acetylation	STLYVS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P26640-2-Acetylation	STLYVS...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P26640-2-Acetylation	STLYVS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P26640-217-unknown	SHQPGP...	217		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14064
P26640-218-unknown	HQPGPE...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5740
P26640-296-unknown	MPDSYS...	296		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000398317
P26640-483-	SAISDI...	483			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P26640-492-unknown	KKELTG...	492		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11386
P26640-1234-unknown	EVQEAD...	1234		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14065

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LPFRYV	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000403464
...LPFRYV	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413365
...LPFRYV	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411088
...LPFRYV	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000413925
...LPFRYV	174	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415275
...GARPLS	216	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14064
...ARPLSH	217	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5740
...DIEVDK	491	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11386
...KGFVPS	970	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000389027
...KGFVPS	970	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000416833
...KGFVPS	970	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000394771
...KGFVPS	970	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415679
...KGFVPS	970	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000405822
...VKVPLE	1233	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14065
...LFQKML	1263	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8226
...FQKML	1264	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FQKML	1264		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FQKML	1264		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	216	RPLS.\|.SHQP	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	217	PLSH.\|.HQPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	491	EVDK.\|.KKEL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	1233	VPLE.\|.EVQE	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CBPA4_HUMAN	1263	QKML.\|.L	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)