P56192: Methionine--tRNA ligase, cytoplasmic

General Information

Protein names	- Methionine--tRNA ligase, cytoplasmic - 6.1.1.10 {ECO:0000269\|PubMed:11714285} - Methionyl-tRNA synthetase - MetRS
Gene names	MARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P56192

9 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRLFVSDGVP GCLPVLAAAG RARGRAEVLI STVGPEDCVV PFLTRPKVPV LQLDSGNYLF
        70         80         90        100        110        120
STSAICRYFF LLSGWEQDDL TNQWLEWEAT ELQPALSAAL YYLVVQGKKG EDVLGSVRRA
       130        140        150        160        170        180
LTHIDHSLSR QNCPFLAGET ESLADIVLWG ALYPLLQDPA YLPEELSALH SWFQTLSTQE
       190        200        210        220        230        240
PCQRAAETVL KQQGVLALRP YLQKQPQPSP AEGRAVTNEP EEEELATLSE EEIAMAVTAW
       250        260        270        280        290        300
EKGLESLPPL RPQQNPVLPV AGERNVLITS ALPYVNNVPH LGNIIGCVLS ADVFARYSRL
       310        320        330        340        350        360
RQWNTLYLCG TDEYGTATET KALEEGLTPQ EICDKYHIIH ADIYRWFNIS FDIFGRTTTP
       370        380        390        400        410        420
QQTKITQDIF QQLLKRGFVL QDTVEQLRCE HCARFLADRF VEGVCPFCGY EEARGDQCDK
       430        440        450        460        470        480
CGKLINAVEL KKPQCKVCRS CPVVQSSQHL FLDLPKLEKR LEEWLGRTLP GSDWTPNAQF
       490        500        510        520        530        540
ITRSWLRDGL KPRCITRDLK WGTPVPLEGF EDKVFYVWFD ATIGYLSITA NYTDQWERWW
       550        560        570        580        590        600
KNPEQVDLYQ FMAKDNVPFH SLVFPCSALG AEDNYTLVSH LIATEYLNYE DGKFSKSRGV
       610        620        630        640        650        660
GVFGDMAQDT GIPADIWRFY LLYIRPEGQD SAFSWTDLLL KNNSELLNNL GNFINRAGMF
       670        680        690        700        710        720
VSKFFGGYVP EMVLTPDDQR LLAHVTLELQ HYHQLLEKVR IRDALRSILT ISRHGNQYIQ
       730        740        750        760        770        780
VNEPWKRIKG SEADRQRAGT VTGLAVNIAA LLSVMLQPYM PTVSATIQAQ LQLPPPACSI
       790        800        810        820        830        840
LLTNFLCTLP AGHQIGTVSP LFQKLENDQI ESLRQRFGGG QAKTSPKPAV VETVTTAKPQ
       850        860        870        880        890        900
QIQALMDEVT KQGNIVRELK AQKADKNEVA AEVAKLLDLK KQLAVAEGKP PEAPKGKKKK

Isoforms

- Isoform 2 of Methionine--tRNA ligase, cytoplasmic

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P56192-1-unknown	MRLFVS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P56192-235-unknown	MAVTAW...	235	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000314653
P56192-246-	SLPPLR...	246		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P56192-246-	SLPPLR...	246		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P56192-246-	SLPPLR...	246		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P56192-369-unknown	IFQQLL...	369	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11726
P56192-377-unknown	GFVLQD...	377	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449071
P56192-645-unknown	ELLNNL...	645	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000449787
P56192-802-unknown	FQKLEN...	802	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14220
P56192-885-unknown	VAEGKP...	885	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6056
P56192-887-unknown	EGKPPE...	887	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7591
P56192-887-unknown	EGKPPE...	887	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6057

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KITQDI	368	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11726
...LADRFV	400	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000447914
...TVSPLF	801	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14220
...KKQLAV	884	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6056
...QLAVAE	886	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7591
...QLAVAE	886	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6057
...GKKKK	900	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	368	TQDI.\|.IFQQ	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	801	SPLF.\|.FQKL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATL1_HUMAN	884	QLAV.\|.VAEG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	886	AVAE.\|.EGKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	886	AVAE.\|.EGKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)