O43776: Asparagine--tRNA ligase, cytoplasmic

General Information

Protein names	- Asparagine--tRNA ligase, cytoplasmic - 6.1.1.22 - Asparaginyl-tRNA synthetase - AsnRS
Gene names	NARS
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43776

9 N-termini

6 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLAELYVSD REGSDATGDG TKEKPFKTGL KALMTVGKEP FPTIYVDSQK ENERWNVISK
        70         80         90        100        110        120
SQLKNIKKMW HREQMKSESR EKKEAEDSLR REKNLEEAKK ITIKNDPSLP EPKCVKIGAL
       130        140        150        160        170        180
EGYRGQRVKV FGWVHRLRRQ GKNLMFLVLR DGTGYLQCVL ADELCQCYNG VLLSTESSVA
       190        200        210        220        230        240
VYGMLNLTPK GKQAPGGHEL SCDFWELIGL APAGGADNLI NEESDVDVQL NNRHMMIRGE
       250        260        270        280        290        300
NMSKILKARS MVTRCFRDHF FDRGYYEVTP PTLVQTQVEG GATLFKLDYF GEEAFLTQSS
       310        320        330        340        350        360
QLYLETCLPA LGDVFCIAQS YRAEQSRTRR HLAEYTHVEA ECPFLTFDDL LNRLEDLVCD
       370        380        390        400        410        420
VVDRILKSPA GSIVHELNPN FQPPKRPFKR MNYSDAIVWL KEHDVKKEDG TFYEFGEDIP
       430        440        450        460        470        480
EAPERLMTDT INEPILLCRF PVEIKSFYMQ RCPEDSRLTE SVDVLMPNVG EIVGGSMRIF
       490        500        510        520        530        540
DSEEILAGYK REGIDPTPYY WYTDQRKYGT CPHGGYGLGL ERFLTWILNR YHIRDVCLYP

RFVQRCTP

Isoforms

- Isoform 2 of Asparagine--tRNA ligase, cytoplasmic

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43776-1-unknown	MVLAEL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43776-2-	VLAELY...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43776-2-	VLAELY...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
O43776-2-	VLAELY...	2		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
O43776-2-	VLAELY...	2		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
O43776-2-unknown	VLAELY...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O43776-2-unknown	VLAELY...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O43776-34-unknown	MTVGKE...	34	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467421
O43776-69-unknown	MWHREQ...	69	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000466606
O43776-224-unknown	SDVDVQ...	224	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10767
O43776-276-unknown	TQVEGG...	276	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5191
O43776-410-	GTFYEF...	410		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
O43776-410-	GTFYEF...	410		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O43776-430-unknown	TINEPI...	430	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10768

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KQAPGG	196	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467421
...KQAPGG	196	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000466606
...QAPGGH	197	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000467651
...LINEES	223	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10767
...PTLVQT	275	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5191
...RLMTDT	429	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10768
...QRCTP	548	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	223	NEES.\|.SDVD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	275	LVQT.\|.TQVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	429	MTDT.\|.TINE	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)