P39748: Flap endonuclease 1 {ECO:0000255|HAMAP-Rule:MF_03140}

General Information

Protein names	- Flap endonuclease 1 {ECO:0000255\|HAMAP-Rule:MF_03140} - FEN-1 {ECO:0000255\|HAMAP-Rule:MF_03140} - 3.1.-.- {ECO:0000255\|HAMAP-Rule:MF_03140} - DNase IV - Flap structure-specific endonuclease 1 {ECO:0000255\|HAMAP-Rule:MF_03140} - Maturation factor 1 - MF1 - hFEN-1
Gene names	FEN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P39748

12 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGIQGLAKLI ADVAPSAIRE NDIKSYFGRK VAIDASMSIY QFLIAVRQGG DVLQNEEGET
        70         80         90        100        110        120
TSHLMGMFYR TIRMMENGIK PVYVFDGKPP QLKSGELAKR SERRAEAEKQ LQQAQAAGAE
       130        140        150        160        170        180
QEVEKFTKRL VKVTKQHNDE CKHLLSLMGI PYLDAPSEAE ASCAALVKAG KVYAAATEDM
       190        200        210        220        230        240
DCLTFGSPVL MRHLTASEAK KLPIQEFHLS RILQELGLNQ EQFVDLCILL GSDYCESIRG
       250        260        270        280        290        300
IGPKRAVDLI QKHKSIEEIV RRLDPNKYPV PENWLHKEAH QLFLEPEVLD PESVELKWSE
       310        320        330        340        350        360
PNEEELIKFM CGEKQFSEER IRSGVKRLSK SRQGSTQGRL DDFFKVTGSL SSAKRKEPEP
       370        380
KGSTKKKAKT GAAGKFKRGK

Isoforms

- Isoform FENMIT of Flap endonuclease 1

Sequence View

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Protein Neighborhood

Domains & Features

12 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P39748-1-unknown	MGIQGL...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P39748-1-unknown	MGIQGL...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P39748-2-unknown	GIQGLA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P39748-2-unknown	GIQGLA...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P39748-65-unknown	MGMFYR...	65	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt75040
P39748-78-	GIKPVY...	78		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P39748-78-unknown	GIKPVY...	78	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176462
P39748-113-unknown	QAQAAG...	113	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7457
P39748-113-unknown	QAQAAG...	113	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139050
P39748-114-unknown	AQAAGA...	114	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5837
P39748-114-unknown	AQAAGA...	114	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139210
P39748-116-unknown	AAGAEQ...	116	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14114
P39748-116-unknown	AAGAEQ...	116	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3789
P39748-116-unknown	AAGAEQ...	116	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139328
P39748-184-unknown	TFGSPV...	184	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14116
P39748-184-unknown	TFGSPV...	184	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143458
P39748-268-unknown	YPVPEN...	268	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17635
P39748-268-unknown	YPVPEN...	268	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146690
P39748-311-unknown	CGEKQF...	311	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11487
P39748-311-unknown	CGEKQF...	311	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148339
P39748-350-unknown	LSSAKR...	350	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11489
P39748-350-unknown	LSSAKR...	350	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149499

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKQLQQ	112	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7457
...EKQLQQ	112	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122121
...KQLQQA	113	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5837
...KQLQQA	113	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122285
...LQQAQA	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14114
...LQQAQA	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3789
...LQQAQA	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122403
...DMDCLT	183	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14116
...DMDCLT	183	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126691
...LDPNKY	267	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17635
...LDPNKY	267	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130000
...LIKFMC	310	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11487
...LIKFMC	310	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131710
...KVTGSL	349	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11489
...KVTGSL	349	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132884
...FKRGK	380	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FKRGK	380	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt70658

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	112	QLQQ.\|.QAQA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	113	LQQA.\|.AQAA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	115	QAQA.\|.AAGA	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATB_HUMAN	115	QAQA.\|.AAGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	183	DCLT.\|.TFGS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
MEP1A_HUMAN	267	PNKY.\|.YPVP	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
GRAB_HUMAN	310	KFMC.\|.CGEK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAB_HUMAN	349	TGSL.\|.LSSA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)