O43414: ERI1 exoribonuclease 3

General Information

Protein names	- ERI1 exoribonuclease 3 - 3.1.-.- - Prion interactor 1 - Prion protein-interacting protein
Gene names	ERI3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O43414

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ERI1 exoribonuclease 3 - Isoform 3 of ERI1 exoribonuclease 3

Sequence View

        10         20         30         40         50         60
MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP ALTEPSASPA
        70         80         90        100        110        120
AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK VLGSHLFSPC GVPEFCSIST
       130        140        150        160        170        180
RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD FEATCDKPQI HPQEIIEFPI LKLNGRTMEI
       190        200        210        220        230        240
ESTFHMYVQP VVHPQLTPFC TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS
       250        260        270        280        290        300
IFVTCGDWDL KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL
       310        320        330
QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF         10         20         30         40         50         60
MATASPAADG GRGRPWEGGL VSWPPAPPLT LPWTWMGPSW GQHPGHWGFP ALTEPSASPA
        70         80         90        100        110        120
AGLGIFEVRR VLDASGCSML APLQTGAARF SSYLLSRARK VLGSHLFSPC GVPEFCSIST
       130        140        150        160        170        180
RKLAAHGFGA SMAAMVSFPP QRYHYFLVLD FEATCDKPQI HPQEIIEFPI LKLNGRTMEI
       190        200        210        220        230        240
ESTFHMYVQP VVHPQLTPFC TELTGIIQAM VDGQPSLQQV LERVDEWMAK EGLLDPNVKS
       250        260        270        280        290        300
IFVTCGDWDL KVMLPGQCQY LGLPVADYFK QWINLKKAYS FAMGCWPKNG LLDMNKGLSL
       310        320        330
QHIGRPHSGI DDCKNIANIM KTLAYRGFIF KQTSKPF

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O43414-1-unknown	MATASP...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O43414-2-acetylation	ATASPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O43414-2-acetylation	ATASPA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O43414-210-unknown	MVDGQP...	210		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74146
O43414-210-unknown	MVDGQP...	210		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104918
O43414-305-unknown	RPHSGI...	305		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5163
O43414-305-unknown	RPHSGI...	305		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142160
O43414-305-unknown	RPHSGI...	305		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146235

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LQHIGR	304	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5163
...LQHIGR	304	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125347
...LQHIGR	304	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129539
...TSKPF	337	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TSKPF	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69764
...TSKPF	337	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69763

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	304	HIGR.\|.RPHS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)