Q7Z5L9: Interferon regulatory factor 2-binding protein 2
Protein names | - Interferon regulatory factor 2-binding protein 2 - IRF-2-binding protein 2 - IRF-2BP2 |
---|---|
Gene names | IRF2BP2 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q7Z5L9 |
11
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK
70 80 90 100 110 120
RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG HGGPEAAPRA PQALERYPLA
130 140 150 160 170 180
AAAERPPRLG SDFGSSRPAA SLAQPPTPQP PPVNGILVPN GFSKLEEPPE LNRQSPNPRR
190 200 210 220 230 240
GHAVPPTLVP LMNGSATPLP TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS
250 260 270 280 290 300
VSSSAAVEHE QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
310 320 330 340 350 360
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV ARTARKRKPS
370 380 390 400 410 420
PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP PPPTASPHSN RTTPPEAAQN
430 440 450 460 470 480
GQSPMAALIL VADNAGGSHA SKDANQVHST TRRNSNSPPS PSSMNQRRLG PREVGGQGAG
490 500 510 520 530 540
NTGGLEPVHP ASLPDSSLAT SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ
550 560 570 580
QGASGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS
Isoforms
- Isoform 2 of Interferon regulatory factor 2-binding protein 2 - Isoform 3 of Interferon regulatory factor 2-binding protein 2Sequence View
10 20 30 40 50 60
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK
70 80 90 100 110 120
RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG HGGPEAAPRA PQALERYPLA
130 140 150 160 170 180
AAAERPPRLG SDFGSSRPAA SLAQPPTPQP PPVNGILVPN GFSKLEEPPE LNRQSPNPRR
190 200 210 220 230 240
GHAVPPTLVP LMNGSATPLP TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS
250 260 270 280 290 300
VSSSAAVEHE QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
310 320 330 340 350 360
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV ARTARKRKPS
370 380 390 400 410 420
PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP PPPTASPHSN RTTPPEAAQN
430 440 450 460 470 480
GQSPMAALIL VADNAGGSHA SKDANQVHST TRRNSNSPPS PSSMNQRRLG PREVGGQGAG
490 500 510 520 530 540
NTGGLEPVHP ASLPDSSLAT SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ
550 560 570 580
QGASGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS
10 20 30 40 50 60
MAAAVAVAAA SRRQSCYLCD LPRMPWAMIW DFTEPVCRGC VNYEGADRVE FVIETARQLK
70 80 90 100 110 120
RAHGCFPEGR SPPGAAASAA AKPPPLSAKD ILLQQQQQLG HGGPEAAPRA PQALERYPLA
130 140 150 160 170 180
AAAERPPRLG SDFGSSRPAA SLAQPPTPQP PPVNGILVPN GFSKLEEPPE LNRQSPNPRR
190 200 210 220 230 240
GHAVPPTLVP LMNGSATPLP TALGLGGRAA ASLAAVSGTA AASLGSAQPT DLGAHKRPAS
250 260 270 280 290 300
VSSSAAVEHE QREAAAKEKQ PPPPAHRGPA DSLSTAAGAA ELSAEGAGKS RGSGEQDWVN
310 320 330 340 350 360
RPKTVRDTLL ALHQHGHSGP FESKFKKEPA LTAGRLLGFE ANGANGSKAV ARTARKRKPS
370 380 390 400 410 420
PEPEGEVGPP KINGEAQPWL STSTEGLKIP MTPTSSFVSP PPPTASPHSN RTTPPEAAQN
430 440 450 460 470 480
GQSPMAALIL VADNAGGSHA SKDANQVHST TRRNSNSPPS PSSMNQRRLG PREVGGQGAG
490 500 510 520 530 540
NTGGLEPVHP ASLPDSSLAT SAPLCCTLCH ERLEDTHFVQ CPSVPSHKFC FPCSRQSIKQ
550 560 570 580
QGASGEVYCP SGEKCPLVGS NVPWAFMQGE IATILAGDVK VKKERDS
Protein Neighborhood
Domains & Features
11 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q7Z5L9-1-unknown | MAAAVA... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77449 | |||
Q7Z5L9-2-unknown | MAAAVA... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q7Z5L9-2-Acetylation | AAAVAV... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q7Z5L9-2-Acetylation | AAAVAV... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
Q7Z5L9-2-Acetylation | AAAVAV... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q7Z5L9-2-Acetylation | AAAVAV... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110852 | ||
Q7Z5L9-161-unknown | GFSKLE... | 161 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171975 | |||
Q7Z5L9-161- | GFSKLE... | 161 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q7Z5L9-161- | GFSKLE... | 161 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
Q7Z5L9-226- | SAQPTD... | 226 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
Q7Z5L9-226- | SAQPTD... | 226 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
Q7Z5L9-226- | SAQPTD... | 226 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q7Z5L9-226- | SAQPTD... | 226 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
Q7Z5L9-226-unknown | SAQPTD... | 226 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6564 | |||
Q7Z5L9-226-unknown | SAQPTD... | 226 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt147595 | |||
Q7Z5L9-243-unknown | SSAAVE... | 243 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7930 | |||
Q7Z5L9-243-unknown | SSAAVE... | 243 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt148230 | |||
Q7Z5L9-311-unknown | ALHQHG... | 311 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175633 | |||
Q7Z5L9-311- | ALHQHG... | 311 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
Q7Z5L9-425-unknown | MAALIL... | 425 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt77450 | |||
Q7Z5L9-425-unknown | MAALIL... | 425 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt103720 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...AASLGS | 225 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6564 | |||
...AASLGS | 225 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt130947 | |||
...PASVSS | 242 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7930 | |||
...PASVSS | 242 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt131597 | |||
...KERDS | 587 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...KERDS | 587 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73068 | |||
...KERDS | 587 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt73067 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 225 | SLGS.|.SAQP | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATS_HUMAN | 242 | SVSS.|.SSAA | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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