Q6P2Q9: Pre-mRNA-processing-splicing factor 8
Protein names | - Pre-mRNA-processing-splicing factor 8 - 220 kDa U5 snRNP-specific protein - PRP8 homolog - Splicing factor Prp8 - p220 |
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Gene names | PRPF8 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q6P2Q9 |
9
N-termini
8
C-termini
6
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MAGVFPYRGP GNPVPGPLAP LPDYMSEEKL QEKARKWQQL QAKRYAEKRK FGFVDAQKED
70 80 90 100 110 120
MPPEHVRKII RDHGDMTNRK FRHDKRVYLG ALKYMPHAVL KLLENMPMPW EQIRDVPVLY
130 140 150 160 170 180
HITGAISFVN EIPWVIEPVY ISQWGSMWIM MRREKRDRRH FKRMRFPPFD DEEPPLDYAD
190 200 210 220 230 240
NILDVEPLEA IQLELDPEED APVLDWFYDH QPLRDSRKYV NGSTYQRWQF TLPMMSTLYR
250 260 270 280 290 300
LANQLLTDLV DDNYFYLFDL KAFFTSKALN MAIPGGPKFE PLVRDINLQD EDWNEFNDIN
310 320 330 340 350 360
KIIIRQPIRT EYKIAFPYLY NNLPHHVHLT WYHTPNVVFI KTEDPDLPAF YFDPLINPIS
370 380 390 400 410 420
HRHSVKSQEP LPDDDEEFEL PEFVEPFLKD TPLYTDNTAN GIALLWAPRP FNLRSGRTRR
430 440 450 460 470 480
ALDIPLVKNW YREHCPAGQP VKVRVSYQKL LKYYVLNALK HRPPKAQKKR YLFRSFKATK
490 500 510 520 530 540
FFQSTKLDWV EVGLQVCRQG YNMLNLLIHR KNLNYLHLDY NFNLKPVKTL TTKERKKSRF
550 560 570 580 590 600
GNAFHLCREV LRLTKLVVDS HVQYRLGNVD AFQLADGLQY IFAHVGQLTG MYRYKYKLMR
610 620 630 640 650 660
QIRMCKDLKH LIYYRFNTGP VGKGPGCGFW AAGWRVWLFF MRGITPLLER WLGNLLARQF
670 680 690 700 710 720
EGRHSKGVAK TVTKQRVESH FDLELRAAVM HDILDMMPEG IKQNKARTIL QHLSEAWRCW
730 740 750 760 770 780
KANIPWKVPG LPTPIENMIL RYVKAKADWW TNTAHYNRER IRRGATVDKT VCKKNLGRLT
790 800 810 820 830 840
RLYLKAEQER QHNYLKDGPY ITAEEAVAVY TTTVHWLESR RFSPIPFPPL SYKHDTKLLI
850 860 870 880 890 900
LALERLKEAY SVKSRLNQSQ REELGLIEQA YDNPHEALSR IKRHLLTQRA FKEVGIEFMD
910 920 930 940 950 960
LYSHLVPVYD VEPLEKITDA YLDQYLWYEA DKRRLFPPWI KPADTEPPPL LVYKWCQGIN
970 980 990 1000 1010 1020
NLQDVWETSE GECNVMLESR FEKMYEKIDL TLLNRLLRLI VDHNIADYMT AKNNVVINYK
1030 1040 1050 1060 1070 1080
DMNHTNSYGI IRGLQFASFI VQYYGLVMDL LVLGLHRASE MAGPPQMPND FLSFQDIATE
1090 1100 1110 1120 1130 1140
AAHPIRLFCR YIDRIHIFFR FTADEARDLI QRYLTEHPDP NNENIVGYNN KKCWPRDARM
1150 1160 1170 1180 1190 1200
RLMKHDVNLG RAVFWDIKNR LPRSVTTVQW ENSFVSVYSK DNPNLLFNMC GFECRILPKC
1210 1220 1230 1240 1250 1260
RTSYEEFTHK DGVWNLQNEV TKERTAQCFL RVDDESMQRF HNRVRQILMA SGSTTFTKIV
1270 1280 1290 1300 1310 1320
NKWNTALIGL MTYFREAVVN TQELLDLLVK CENKIQTRIK IGLNSKMPSR FPPVVFYTPK
1330 1340 1350 1360 1370 1380
ELGGLGMLSM GHVLIPQSDL RWSKQTDVGI THFRSGMSHE EDQLIPNLYR YIQPWESEFI
1390 1400 1410 1420 1430 1440
DSQRVWAEYA LKRQEAIAQN RRLTLEDLED SWDRGIPRIN TLFQKDRHTL AYDKGWRVRT
1450 1460 1470 1480 1490 1500
DFKQYQVLKQ NPFWWTHQRH DGKLWNLNNY RTDMIQALGG VEGILEHTLF KGTYFPTWEG
1510 1520 1530 1540 1550 1560
LFWEKASGFE ESMKWKKLTN AQRSGLNQIP NRRFTLWWSP TINRANVYVG FQVQLDLTGI
1570 1580 1590 1600 1610 1620
FMHGKIPTLK ISLIQIFRAH LWQKIHESIV MDLCQVFDQE LDALEIETVQ KETIHPRKSY
1630 1640 1650 1660 1670 1680
KMNSSCADIL LFASYKWNVS RPSLLADSKD VMDSTTTQKY WIDIQLRWGD YDSHDIERYA
1690 1700 1710 1720 1730 1740
RAKFLDYTTD NMSIYPSPTG VLIAIDLAYN LHSAYGNWFP GSKPLIQQAM AKIMKANPAL
1750 1760 1770 1780 1790 1800
YVLRERIRKG LQLYSSEPTE PYLSSQNYGE LFSNQIIWFV DDTNVYRVTI HKTFEGNLTT
1810 1820 1830 1840 1850 1860
KPINGAIFIF NPRTGQLFLK IIHTSVWAGQ KRLGQLAKWK TAEEVAALIR SLPVEEQPKQ
1870 1880 1890 1900 1910 1920
IIVTRKGMLD PLEVHLLDFP NIVIKGSELQ LPFQACLKVE KFGDLILKAT EPQMVLFNLY
1930 1940 1950 1960 1970 1980
DDWLKTISSY TAFSRLILIL RALHVNNDRA KVILKPDKTT ITEPHHIWPT LTDEEWIKVE
1990 2000 2010 2020 2030 2040
VQLKDLILAD YGKKNNVNVA SLTQSEIRDI ILGMEISAPS QQRQQIAEIE KQTKEQSQLT
2050 2060 2070 2080 2090 2100
ATQTRTVNKH GDEIITSTTS NYETQTFSSK TEWRVRAISA ANLHLRTNHI YVSSDDIKET
2110 2120 2130 2140 2150 2160
GYTYILPKNV LKKFICISDL RAQIAGYLYG VSPPDNPQVK EIRCIVMVPQ WGTHQTVHLP
2170 2180 2190 2200 2210 2220
GQLPQHEYLK EMEPLGWIHT QPNESPQLSP QDVTTHAKIM ADNPSWDGEK TIIITCSFTP
2230 2240 2250 2260 2270 2280
GSCTLTAYKL TPSGYEWGRQ NTDKGNNPKG YLPSHYERVQ MLLSDRFLGF FMVPAQSSWN
2290 2300 2310 2320 2330
YNFMGVRHDP NMKYELQLAN PKEFYHEVHR PSHFLNFALL QEGEVYSADR EDLYA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
9 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q6P2Q9-2-unknown | MAGVFP... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q6P2Q9-2-Acetylation | AGVFPY... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
Q6P2Q9-2-Acetylation | AGVFPY... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
Q6P2Q9-2-Acetylation | AGVFPY... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
Q6P2Q9-24-unknown | YMSEEK... | 24 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12598 | |||
Q6P2Q9-272- | AIPGGP... | 272 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
Q6P2Q9-757-unknown | NRERIR... | 757 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
Q6P2Q9-869-unknown | QAYDNP... | 869 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6549 | |||
Q6P2Q9-869-unknown | QAYDNP... | 869 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7918 | |||
Q6P2Q9-1076-unknown | DIATEA... | 1076 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6550 | |||
Q6P2Q9-1358-unknown | SHEEDQ... | 1358 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14618 | |||
Q6P2Q9-1966-unknown | HIWPTL... | 1966 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14619 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...APLPDY | 23 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC12598 | |||
...LGLIEQ | 868 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6549 | |||
...LGLIEQ | 868 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7918 | |||
...GPPQMP | 1067 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000458151 | |||
...FLSFQD | 1075 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC6550 | |||
...FRSGMS | 1357 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14618 | |||
...DALEIE | 1606 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000460849 | |||
...ITEPHH | 1965 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC14619 | |||
...EDLYA | 2335 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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