P39023: 60S ribosomal protein L3

General Information

Protein names	- 60S ribosomal protein L3 - HIV-1 TAR RNA-binding protein B - TARBP-B - Large ribosomal subunit protein uL3 {ECO:0000303\|PubMed:24524803}
Gene names	RPL3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P39023

18 N-termini

14 C-termini

14 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHRKFSAPR HGSLGFLPRK RSSRHRGKVK SFPKDDPSKP VHLTAFLGYK AGMTHIVREV
        70         80         90        100        110        120
DRPGSKVNKK EVVEAVTIVE TPPMVVVGIV GYVETPRGLR TFKTVFAEHI SDECKRRFYK
       130        140        150        160        170        180
NWHKSKKKAF TKYCKKWQDE DGKKQLEKDF SSMKKYCQVI RVIAHTQMRL LPLRQKKAHL
       190        200        210        220        230        240
MEIQVNGGTV AEKLDWARER LEQQVPVNQV FGQDEMIDVI GVTKGKGYKG VTSRWHTKKL
       250        260        270        280        290        300
PRKTHRGLRK VACIGAWHPA RVAFSVARAG QKGYHHRTEI NKKIYKIGQG YLIKDGKLIK
       310        320        330        340        350        360
NNASTDYDLS DKSINPLGGF VHYGEVTNDF VMLKGCVVGT KKRVLTLRKS LLVQTKRRAL
       370        380        390        400
EKIDLKFIDT TSKFGHGRFQ TMEEKKAFMG PLKKDRIAKE EGA

Isoforms

Sequence View

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P39023-2-unknown	SHRKFS...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P39023-11-unknown	HGSLGF...	11	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10068
P39023-31-	SFPKDD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P39023-31-	SFPKDD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P39023-31-	SFPKDD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P39023-31-	SFPKDD...	31		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P39023-31-	SFPKDD...	31		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P39023-31-	SFPKDD...	31		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P39023-35-unknown	DDPSKP...	35	inferred from electronic annotation	unknown	TISdb		inferred from TISdb
P39023-51-unknown	AGMTHI...	51	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10069
P39023-53-unknown	MTHIVR...	53	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000386101
P39023-53-unknown	MTHIVR...	53	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385762
P39023-107-unknown	AEHISD...	107	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7454
P39023-107-unknown	AEHISD...	107	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5831
P39023-108-unknown	EHISDE...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7455
P39023-108-unknown	EHISDE...	108	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5832
P39023-182-unknown	EIQVNG...	182	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7456
P39023-182-unknown	EIQVNG...	182	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5833
P39023-215-unknown	EMIDVI...	215	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11483
P39023-215-unknown	EMIDVI...	215	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17631
P39023-298-	LIKNNA...	298		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P39023-298-	LIKNNA...	298		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P39023-298-	LIKNNA...	298		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P39023-303-	ASTDYD...	303		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P39023-313-	SINPLG...	313		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P39023-313-	SINPLG...	313		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P39023-313-	SINPLG...	313		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P39023-313-	SINPLG...	313		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P39023-319-unknown	GFVHYG...	319	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3787
P39023-325-unknown	EVTNDF...	325	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5834
P39023-366-unknown	KFIDTT...	366	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14112
P39023-387-	AFMGPL...	387		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P39023-390-unknown	GPLKKD...	390	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14113

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...FSAPRH	10	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10068
...FLGYKA	50	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10069
...FKTVFA	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7454
...FKTVFA	106	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5831
...KTVFAE	107	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7455
...KTVFAE	107	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5832
...KAHLME	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7456
...KAHLME	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5833
...VFGQDE	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11483
...VFGQDE	214	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17631
...GKGYKG	229	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000412713
...YHHRTE	278	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000415198
...INPLGG	318	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3787
...GFVHYG	323	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385762
...GFVHYG	323	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5834
...EKIDLK	365	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14112
...KKAFMG	389	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14113
...KEEGA	403	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...KEEGA	403		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KEEGA	403		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...KEEGA	403		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...KEEGA	403		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	10	APRH.\|.HGSL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	50	GYKA.\|.AGMT	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATS_HUMAN	106	TVFA.\|.AEHI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	106	TVFA.\|.AEHI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	107	VFAE.\|.EHIS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	107	VFAE.\|.EHIS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	181	HLME.\|.EIQV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	181	HLME.\|.EIQV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	214	GQDE.\|.EMID	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
MEP1A_HUMAN	214	GQDE.\|.EMID	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	318	PLGG.\|.GFVH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	324	HYGE.\|.EVTN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAM_HUMAN	365	IDLK.\|.KFID	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAM_HUMAN	389	AFMG.\|.GPLK	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,

TopFIND

P39023: 60S ribosomal protein L3

General Information

18

N-termini

14

C-termini

14

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

18 N-termini - 14 C-termini - 14 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates