Q9NX46: ADP-ribose glycohydrolase ARH3 {ECO:0000305}

General Information

Protein names	- ADP-ribose glycohydrolase ARH3 {ECO:0000305} - ADP-ribosylhydrolase 3 {ECO:0000303\|PubMed:16278211} - O-acetyl-ADP-ribose deacetylase ARH3 {ECO:0000305} - 3.5.1.- {ECO:0000269\|PubMed:17075046, ECO:0000269\|PubMed:21498885} - Poly(ADP-ribose) glycohydrolase ARH3 {ECO:0000305} - 3.2.1.143 {ECO:0000269\|PubMed:16278211, ECO:0000269\|PubMed:17075046, ECO:0000269\|PubMed:22433848} - Protein ADP-ribosylarginine] hydrolase-like protein 2 {ECO:0000305} - Protein ADP-ribosylserine] hydrolase {ECO:0000305} - 3.2.2.- {ECO:0000269\|PubMed:28650317, ECO:0000269\|PubMed:29234005}
Gene names	ADPRHL2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9NX46

5 N-termini

2 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAAMAAAA GGGAGAARSL SRFRGCLAGA LLGDCVGSFY EAHDTVDLTS VLRHVQSLEP
        70         80         90        100        110        120
DPGTPGSERT EALYYTDDTA MARALVQSLL AKEAFDEVDM AHRFAQEYKK DPDRGYGAGV
       130        140        150        160        170        180
VTVFKKLLNP KCRDVFEPAR AQFNGKGSYG NGGAMRVAGI SLAYSSVQDV QKFARLSAQL
       190        200        210        220        230        240
THASSLGYNG AILQALAVHL ALQGESSSEH FLKQLLGHME DLEGDAQSVL DARELGMEER
       250        260        270        280        290        300
PYSSRLKKIG ELLDQASVTR EEVVSELGNG IAAFESVPTA IYCFLRCMEP DPEIPSAFNS
       310        320        330        340        350        360
LQRTLIYSIS LGGDTDTIAT MAGAIAGAYY GMDQVPESWQ QSCEGYEETD ILAQSLHRVF

QKS

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9NX46-2-acetylation	AAAAMA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9NX46-2-acetylation	AAAAMA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9NX46-2-acetylation	AAAAMA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9NX46-2-acetylation	AAAAMA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9NX46-3-acetylation	AAAMAA...	3	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9NX46-7-acetylation	AAAAGG...	7	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9NX46-28-unknown	AGALLG...	28		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9NX46-204-unknown	GESSSE...	204		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6819
Q9NX46-204-unknown	GESSSE...	204		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8113

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HLALQG	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6819
...HLALQG	203	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8113
...VFQKS	363	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	203	ALQG.\|.GESS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	203	ALQG.\|.GESS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)