Q06830: Peroxiredoxin-1

General Information

Protein names	- Peroxiredoxin-1 - 1.11.1.15 {ECO:0000269\|PubMed:11986303, ECO:0000269\|PubMed:9497357} - Natural killer cell-enhancing factor A - NKEF-A - Proliferation-associated gene protein - PAG - Thioredoxin peroxidase 2 - Thioredoxin-dependent peroxide reductase 2
Gene names	PRDX1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q06830

15 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS
        70         80         90        100        110        120
DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK
       130        140        150        160        170        180
ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG
       190
SDTIKPDVQK SKEYFSKQK

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

15 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q06830-2-unknown	MSSGNA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06830-2-Acetylation	SSGNAK...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q06830-44-unknown	YPLDFT...	44		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q06830-49-	TFVCPT...	49			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q06830-76-unknown	ASVDSH...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7734
Q06830-76-unknown	ASVDSH...	76		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6240
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q06830-93-	KQGGLG...	93			Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
Q06830-93-unknown	KQGGLG...	93			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q06830-96-	GLGPMN...	96			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q06830-96-	GLGPMN...	96			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q06830-96-	GLGPMN...	96			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q06830-111-	TIAQDY...	111			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q06830-111-acetylation	TIAQDY...	111	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q06830-162-unknown	AFQFTD...	162		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6241
Q06830-181-unknown	SDTIKP...	181		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17857
Q06830-182-unknown	DTIKPD...	182		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17858
Q06830-191-unknown	SKEYFS...	191			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q06830-191-	SKEYFS...	191			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CQVIGA	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7734
...CQVIGA	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6240
...LRLVQA	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6241
...DKHGEV	171	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407034
...DKHGEV	171	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389047
...GWKPGS	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17857
...WKPGSD	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17858
...FSKQK	199	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	75	VIGA.\|.ASVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	75	VIGA.\|.ASVD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	161	LVQA.\|.AFQF	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	180	KPGS.\|.SDTI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	181	PGSD.\|.DTIK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)