O75643: U5 small nuclear ribonucleoprotein 200 kDa helicase

General Information

Protein names	- U5 small nuclear ribonucleoprotein 200 kDa helicase - 3.6.4.13 {ECO:0000269\|PubMed:23045696} - Activating signal cointegrator 1 complex subunit 3-like 1 - BRR2 homolog - U5 snRNP-specific 200 kDa protein - U5-200KD
Gene names	SNRNP200
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O75643

9 N-termini

8 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADVTARSLQ YEYKANSNLV LQADRSLIDR TRRDEPTGEV LSLVGKLEGT RMGDKAQRTK
        70         80         90        100        110        120
PQMQEERRAK RRKRDEDRHD INKMKGYTLL SEGIDEMVGI IYKPKTKETR ETYEVLLSFI
       130        140        150        160        170        180
QAALGDQPRD ILCGAADEVL AVLKNEKLRD KERRKEIDLL LGQTDDTRYH VLVNLGKKIT
       190        200        210        220        230        240
DYGGDKEIQN MDDNIDETYG VNVQFESDEE EGDEDVYGEV REEASDDDME GDEAVVRCTL
       250        260        270        280        290        300
SANLVASGEL MSSKKKDLHP RDIDAFWLQR QLSRFYDDAI VSQKKADEVL EILKTASDDR
       310        320        330        340        350        360
ECENQLVLLL GFNTFDFIKV LRQHRMMILY CTLLASAQSE AEKERIMGKM EADPELSKFL
       370        380        390        400        410        420
YQLHETEKED LIREERSRRE RVRQSRMDTD LETMDLDQGG EALAPRQVLD LEDLVFTQGS
       430        440        450        460        470        480
HFMANKRCQL PDGSFRRQRK GYEEVHVPAL KPKPFGSEEQ LLPVEKLPKY AQAGFEGFKT
       490        500        510        520        530        540
LNRIQSKLYR AALETDENLL LCAPTGAGKT NVALMCMLRE IGKHINMDGT INVDDFKIIY
       550        560        570        580        590        600
IAPMRSLVQE MVGSFGKRLA TYGITVAELT GDHQLCKEEI SATQIIVCTP EKWDIITRKG
       610        620        630        640        650        660
GERTYTQLVR LIILDEIHLL HDDRGPVLEA LVARAIRNIE MTQEDVRLIG LSATLPNYED
       670        680        690        700        710        720
VATFLRVDPA KGLFYFDNSF RPVPLEQTYV GITEKKAIKR FQIMNEIVYE KIMEHAGKNQ
       730        740        750        760        770        780
VLVFVHSRKE TGKTARAIRD MCLEKDTLGL FLREGSASTE VLRTEAEQCK NLELKDLLPY
       790        800        810        820        830        840
GFAIHHAGMT RVDRTLVEDL FADKHIQVLV STATLAWGVN LPAHTVIIKG TQVYSPEKGR
       850        860        870        880        890        900
WTELGALDIL QMLGRAGRPQ YDTKGEGILI TSHGELQYYL SLLNQQLPIE SQMVSKLPDM
       910        920        930        940        950        960
LNAEIVLGNV QNAKDAVNWL GYAYLYIRML RSPTLYGISH DDLKGDPLLD QRRLDLVHTA
       970        980        990       1000       1010       1020
ALMLDKNNLV KYDKKTGNFQ VTELGRIASH YYITNDTVQT YNQLLKPTLS EIELFRVFSL
      1030       1040       1050       1060       1070       1080
SSEFKNITVR EEEKLELQKL LERVPIPVKE SIEEPSAKIN VLLQAFISQL KLEGFALMAD
      1090       1100       1110       1120       1130       1140
MVYVTQSAGR LMRAIFEIVL NRGWAQLTDK TLNLCKMIDK RMWQSMCPLR QFRKLPEEVV
      1150       1160       1170       1180       1190       1200
KKIEKKNFPF ERLYDLNHNE IGELIRMPKM GKTIHKYVHL FPKLELSVHL QPITRSTLKV
      1210       1220       1230       1240       1250       1260
ELTITPDFQW DEKVHGSSEA FWILVEDVDS EVILHHEYFL LKAKYAQDEH LITFFVPVFE
      1270       1280       1290       1300       1310       1320
PLPPQYFIRV VSDRWLSCET QLPVSFRHLI LPEKYPPPTE LLDLQPLPVS ALRNSAFESL
      1330       1340       1350       1360       1370       1380
YQDKFPFFNP IQTQVFNTVY NSDDNVFVGA PTGSGKTICA EFAILRMLLQ SSEGRCVYIT
      1390       1400       1410       1420       1430       1440
PMEALAEQVY MDWYEKFQDR LNKKVVLLTG ETSTDLKLLG KGNIIISTPE KWDILSRRWK
      1450       1460       1470       1480       1490       1500
QRKNVQNINL FVVDEVHLIG GENGPVLEVI CSRMRYISSQ IERPIRIVAL SSSLSNAKDV
      1510       1520       1530       1540       1550       1560
AHWLGCSATS TFNFHPNVRP VPLELHIQGF NISHTQTRLL SMAKPVYHAI TKHSPKKPVI
      1570       1580       1590       1600       1610       1620
VFVPSRKQTR LTAIDILTTC AADIQRQRFL HCTEKDLIPY LEKLSDSTLK ETLLNGVGYL
      1630       1640       1650       1660       1670       1680
HEGLSPMERR LVEQLFSSGA IQVVVASRSL CWGMNVAAHL VIIMDTQYYN GKIHAYVDYP
      1690       1700       1710       1720       1730       1740
IYDVLQMVGH ANRPLQDDEG RCVIMCQGSK KDFFKKFLYE PLPVESHLDH CMHDHFNAEI
      1750       1760       1770       1780       1790       1800
VTKTIENKQD AVDYLTWTFL YRRMTQNPNY YNLQGISHRH LSDHLSELVE QTLSDLEQSK
      1810       1820       1830       1840       1850       1860
CISIEDEMDV APLNLGMIAA YYYINYTTIE LFSMSLNAKT KVRGLIEIIS NAAEYENIPI
      1870       1880       1890       1900       1910       1920
RHHEDNLLRQ LAQKVPHKLN NPKFNDPHVK TNLLLQAHLS RMQLSAELQS DTEEILSKAI
      1930       1940       1950       1960       1970       1980
RLIQACVDVL SSNGWLSPAL AAMELAQMVT QAMWSKDSYL KQLPHFTSEH IKRCTDKGVE
      1990       2000       2010       2020       2030       2040
SVFDIMEMED EERNALLQLT DSQIADVARF CNRYPNIELS YEVVDKDSIR SGGPVVVLVQ
      2050       2060       2070       2080       2090       2100
LEREEEVTGP VIAPLFPQKR EEGWWVVIGD AKSNSLISIK RLTLQQKAKV KLDFVAPATG
      2110       2120       2130
AHNYTLYFMS DAYMGCDQEY KFSVDVKEAE TDSDSD

Isoforms

- Isoform 2 of U5 small nuclear ribonucleoprotein 200 kDa helicase

Sequence View

        10         20         30         40         50         60
MADVTARSLQ YEYKANSNLV LQADRSLIDR TRRDEPTGEV LSLVGKLEGT RMGDKAQRTK
        70         80         90        100        110        120
PQMQEERRAK RRKRDEDRHD INKMKGYTLL SEGIDEMVGI IYKPKTKETR ETYEVLLSFI
       130        140        150        160        170        180
QAALGDQPRD ILCGAADEVL AVLKNEKLRD KERRKEIDLL LGQTDDTRYH VLVNLGKKIT
       190        200        210        220        230        240
DYGGDKEIQN MDDNIDETYG VNVQFESDEE EGDEDVYGEV REEASDDDME GDEAVVRCTL
       250        260        270        280        290        300
SANLVASGEL MSSKKKDLHP RDIDAFWLQR QLSRFYDDAI VSQKKADEVL EILKTASDDR
       310        320        330        340        350        360
ECENQLVLLL GFNTFDFIKV LRQHRMMILY CTLLASAQSE AEKERIMGKM EADPELSKFL
       370        380        390        400        410        420
YQLHETEKED LIREERSRRE RVRQSRMDTD LETMDLDQGG EALAPRQVLD LEDLVFTQGS
       430        440        450        460        470        480
HFMANKRCQL PDGSFRRQRK GYEEVHVPAL KPKPFGSEEQ LLPVEKLPKY AQAGFEGFKT
       490        500        510        520        530        540
LNRIQSKLYR AALETDENLL LCAPTGAGKT NVALMCMLRE IGKHINMDGT INVDDFKIIY
       550        560        570        580        590        600
IAPMRSLVQE MVGSFGKRLA TYGITVAELT GDHQLCKEEI SATQIIVCTP EKWDIITRKG
       610        620        630        640        650        660
GERTYTQLVR LIILDEIHLL HDDRGPVLEA LVARAIRNIE MTQEDVRLIG LSATLPNYED
       670        680        690        700        710        720
VATFLRVDPA KGLFYFDNSF RPVPLEQTYV GITEKKAIKR FQIMNEIVYE KIMEHAGKNQ
       730        740        750        760        770        780
VLVFVHSRKE TGKTARAIRD MCLEKDTLGL FLREGSASTE VLRTEAEQCK NLELKDLLPY
       790        800        810        820        830        840
GFAIHHAGMT RVDRTLVEDL FADKHIQVLV STATLAWGVN LPAHTVIIKG TQVYSPEKGR
       850        860        870        880        890        900
WTELGALDIL QMLGRAGRPQ YDTKGEGILI TSHGELQYYL SLLNQQLPIE SQMVSKLPDM
       910        920        930        940        950        960
LNAEIVLGNV QNAKDAVNWL GYAYLYIRML RSPTLYGISH DDLKGDPLLD QRRLDLVHTA
       970        980        990       1000       1010       1020
ALMLDKNNLV KYDKKTGNFQ VTELGRIASH YYITNDTVQT YNQLLKPTLS EIELFRVFSL
      1030       1040       1050       1060       1070       1080
SSEFKNITVR EEEKLELQKL LERVPIPVKE SIEEPSAKIN VLLQAFISQL KLEGFALMAD
      1090       1100       1110       1120       1130       1140
MVYVTQSAGR LMRAIFEIVL NRGWAQLTDK TLNLCKMIDK RMWQSMCPLR QFRKLPEEVV
      1150       1160       1170       1180       1190       1200
KKIEKKNFPF ERLYDLNHNE IGELIRMPKM GKTIHKYVHL FPKLELSVHL QPITRSTLKV
      1210       1220       1230       1240       1250       1260
ELTITPDFQW DEKVHGSSEA FWILVEDVDS EVILHHEYFL LKAKYAQDEH LITFFVPVFE
      1270       1280       1290       1300       1310       1320
PLPPQYFIRV VSDRWLSCET QLPVSFRHLI LPEKYPPPTE LLDLQPLPVS ALRNSAFESL
      1330       1340       1350       1360       1370       1380
YQDKFPFFNP IQTQVFNTVY NSDDNVFVGA PTGSGKTICA EFAILRMLLQ SSEGRCVYIT
      1390       1400       1410       1420       1430       1440
PMEALAEQVY MDWYEKFQDR LNKKVVLLTG ETSTDLKLLG KGNIIISTPE KWDILSRRWK
      1450       1460       1470       1480       1490       1500
QRKNVQNINL FVVDEVHLIG GENGPVLEVI CSRMRYISSQ IERPIRIVAL SSSLSNAKDV
      1510       1520       1530       1540       1550       1560
AHWLGCSATS TFNFHPNVRP VPLELHIQGF NISHTQTRLL SMAKPVYHAI TKHSPKKPVI
      1570       1580       1590       1600       1610       1620
VFVPSRKQTR LTAIDILTTC AADIQRQRFL HCTEKDLIPY LEKLSDSTLK ETLLNGVGYL
      1630       1640       1650       1660       1670       1680
HEGLSPMERR LVEQLFSSGA IQVVVASRSL CWGMNVAAHL VIIMDTQYYN GKIHAYVDYP
      1690       1700       1710       1720       1730       1740
IYDVLQMVGH ANRPLQDDEG RCVIMCQGSK KDFFKKFLYE PLPVESHLDH CMHDHFNAEI
      1750       1760       1770       1780       1790       1800
VTKTIENKQD AVDYLTWTFL YRRMTQNPNY YNLQGISHRH LSDHLSELVE QTLSDLEQSK
      1810       1820       1830       1840       1850       1860
CISIEDEMDV APLNLGMIAA YYYINYTTIE LFSMSLNAKT KVRGLIEIIS NAAEYENIPI
      1870       1880       1890       1900       1910       1920
RHHEDNLLRQ LAQKVPHKLN NPKFNDPHVK TNLLLQAHLS RMQLSAELQS DTEEILSKAI
      1930       1940       1950       1960       1970       1980
RLIQACVDVL SSNGWLSPAL AAMELAQMVT QAMWSKDSYL KQLPHFTSEH IKRCTDKGVE
      1990       2000       2010       2020       2030       2040
SVFDIMEMED EERNALLQLT DSQIADVARF CNRYPNIELS YEVVDKDSIR SGGPVVVLVQ
      2050       2060       2070       2080       2090       2100
LEREEEVTGP VIAPLFPQKR EEGWWVVIGD AKSNSLISIK RLTLQQKAKV KLDFVAPATG
      2110       2120       2130
AHNYTLYFMS DAYMGCDQEY KFSVDVKEAE TDSDSD

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O75643-1-unknown	MADVTA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O75643-1-unknown	MADVTA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93523
O75643-391-unknown	LETMDL...	391	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10957
O75643-391-unknown	LETMDL...	391	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151861
O75643-447-unknown	VPALKP...	447	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5265
O75643-447-unknown	VPALKP...	447	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152752
O75643-821-unknown	LPAHTV...	821	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5267
O75643-821-unknown	LPAHTV...	821	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7067
O75643-937-	GISHDD...	937		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
O75643-942-unknown	DLKGDP...	942	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10959
O75643-1690-unknown	HANRPL...	1690	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5268
O75643-1690-unknown	HANRPL...	1690	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7068
O75643-2002-unknown	SQIADV...	2002	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10960
O75643-2019-unknown	LSYEVV...	2019	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5269

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RMDTDL	390	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10957
...RMDTDL	390	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135267
...YEEVHV	446	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5265
...YEEVHV	446	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136172
...AWGVNL	820	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5267
...AWGVNL	820	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7067
...GISHDD	941	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10959
...LQMVGH	1689	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5268
...LQMVGH	1689	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7068
...LQLTDS	2001	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10960
...YPNIEL	2018	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5269
...DSDSD	2136	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DSDSD	2136	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89141

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	390	DTDL.\|.LETM	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATL1_HUMAN	446	EVHV.\|.VPAL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	820	GVNL.\|.LPAH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	820	GVNL.\|.LPAH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	941	SHDD.\|.DLKG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATL1_HUMAN	1689	MVGH.\|.HANR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	1689	MVGH.\|.HANR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	2001	LTDS.\|.SQIA	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CATL1_HUMAN	2018	NIEL.\|.LSYE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

TopFIND

O75643: U5 small nuclear ribonucleoprotein 200 kDa helicase

General Information

9

N-termini

8

C-termini

9

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

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Protein Neighborhood

Domains & Features

9 N-termini - 8 C-termini - 9 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates