O00629: Importin subunit alpha-3

General Information

Protein names	- Importin subunit alpha-3 - Importin alpha Q1 - Qip1 - Karyopherin subunit alpha-4
Gene names	KPNA4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	O00629

6 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS
        70         80         90        100        110        120
DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV
       130        140        150        160        170        180
HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA
       190        200        210        220        230        240
LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI
       250        260        270        280        290        300
QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV
       310        320        330        340        350        360
QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ
       370        380        390        400        410        420
VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL
       430        440        450        460        470        480
TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI
       490        500        510        520
IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
O00629-2-unknown	MADNEK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00629-2-Acetylation	ADNEKL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
O00629-2-Acetylation	ADNEKL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
O00629-2-Acetylation	ADNEKL...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
O00629-2-Acetylation	ADNEKL...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
O00629-60-unknown	SDIDGD...	60		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10666
O00629-101-unknown	SDRNPP...	101		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5105
O00629-296-unknown	QEVKVQ...	296		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417172
O00629-467-unknown	NHENED...	467		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6992
O00629-467-unknown	NHENED...	467		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5106

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DICEDS	59	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10666
...RKLLSS	100	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5105
...IEQLQN	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6992
...IEQLQN	466	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5106
...FSSDDI	489	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417172
...EGFQF	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	59	CEDS.\|.SDID	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,
CATL1_HUMAN	100	LLSS.\|.SDRN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	466	QLQN.\|.NHEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	466	QLQN.\|.NHEN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)