Q92597: Protein NDRG1

General Information

Protein names	- Protein NDRG1 - Differentiation-related gene 1 protein - DRG-1 - N-myc downstream-regulated gene 1 protein - Nickel-specific induction protein Cap43 - Reducing agents and tunicamycin-responsive protein - RTP - Rit42
Gene names	NDRG1
Organism	Homo sapiens
Protease Family
Protease ID	S33.988
Chromosome location
UniProt ID	Q92597

10 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Protein NDRG1 - Isoform 3 of Protein NDRG1

Sequence View

        10         20         30         40         50         60
MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL
        70         80         90        100        110        120
TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE
       130        140        150        160        170        180
MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI
       190        200        210        220        230        240
SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE
       250        260        270        280        290        300
RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK
       310        320        330        340        350        360
LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT
       370        380        390
RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSC         10         20         30         40         50         60
MSREMQDVDL AEVKPLVEKG ETITGLLQEF DVQEQDIETL HGSVHVTLCG TPKGNRPVIL
        70         80         90        100        110        120
TYHDIGMNHK TCYNPLFNYE DMQEITQHFA VCHVDAPGQQ DGAASFPAGY MYPSMDQLAE
       130        140        150        160        170        180
MLPGVLQQFG LKSIIGMGTG AGAYILTRFA LNNPEMVEGL VLINVNPCAE GWMDWAASKI
       190        200        210        220        230        240
SGWTQALPDM VVSHLFGKEE MQSNVEVVHT YRQHIVNDMN PGNLHLFINA YNSRRDLEIE
       250        260        270        280        290        300
RPMPGTHTVT LQCPALLVVG DSSPAVDAVV ECNSKLDPTK TTLLKMADCG GLPQISQPAK
       310        320        330        340        350        360
LAEAFKYFVQ GMGYMPSASM TRLMRSRTAS GSSVTSLDGT RSRSHTSEGT RSRSHTSEGT
       370        380        390
RSRSHTSEGA HLDITPNSGA AGNSAGPKSM EVSC

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92597-2-unknown	MSREMQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92597-2-Acetylation	SREMQD...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92597-10-	LAEVKP...	10			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q92597-10-	LAEVKP...	10			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q92597-11-	AEVKPL...	11			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q92597-67-unknown	MNHKTC...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82477
Q92597-82-unknown	MQEITQ...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82478
Q92597-82-unknown	MQEITQ...	82		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt98442
Q92597-190-unknown	MVVSHL...	190		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1334
Q92597-190-unknown	MVVSHL...	190		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142869
Q92597-190-unknown	MVVSHL...	190		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143645
Q92597-203-unknown	SNVEVV...	203		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7973
Q92597-203-unknown	SNVEVV...	203		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143554
Q92597-203-unknown	SNVEVV...	203		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144160
Q92597-218-unknown	DMNPGN...	218		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7976
Q92597-218-unknown	DMNPGN...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144161
Q92597-218-unknown	DMNPGN...	218		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144806
Q92597-374-unknown	ITPNSG...	374		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6621
Q92597-374-unknown	ITPNSG...	374		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149693
Q92597-374-unknown	ITPNSG...	374		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150089

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QALPDM	189	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1334
...QALPDM	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126078
...QALPDM	189	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126887
...KEEMQS	202	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7973
...KEEMQS	202	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126794
...KEEMQS	202	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127413
...QHIVND	217	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7976
...QHIVND	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127414
...QHIVND	217	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128082
...GAHLDI	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6621
...GAHLDI	373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133081
...GAHLDI	373	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133481
...MEVSC	394	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MEVSC	394	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78096
...MEVSC	394	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78095

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	189	LPDM.\|.MVVS	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CATS_HUMAN	202	EMQS.\|.SNVE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	217	IVND.\|.DMNP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	373	HLDI.\|.ITPN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)