P37108: Signal recognition particle 14 kDa protein

General Information

Protein names	- Signal recognition particle 14 kDa protein - SRP14 - 18 kDa Alu RNA-binding protein
Gene names	SRP14
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P37108

9 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLLESEQFL TELTRLFQKC RTSGSVYITL KKYDGRTKPI PKKGTVEGFE PADNKCLLRA
        70         80         90        100        110        120
TDGKKKISTV VSSKEVNKFQ MAYSNLLRAN MDGLKKRDKK NKTKKTKAAA AAAAAAPAAA
       130
ATAPTTAATT AATAAQ

Isoforms

Sequence View

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Evidence Codes:

Methodology:

Perturbation of System:

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Protease Assignment Confidence:

Evidence Names:

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Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P37108-1-unknown	MVLLES...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P37108-1-unknown	MVLLES...	1		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P37108-1-	MVLLES...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P37108-1-	MVLLES...	1		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P37108-1-	MVLLES...	1		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P37108-1-	MVLLES...	1		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P37108-2-unmodified	VLLESE...	2		other		CNRS/ISV	Large_scale_NTA_Human
P37108-2-unknown	VLLESE...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P37108-2-unknown	VLLESE...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P37108-2-unknown	VLLESE...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P37108-2-	VLLESE...	2		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P37108-43-unknown	KGTVEG...	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10064
P37108-43-unknown	KGTVEG...	43		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P37108-43-	KGTVEG...	43		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P37108-43-	KGTVEG...	43		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P37108-43-	KGTVEG...	43		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P37108-43-	KGTVEG...	43		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P37108-48-unknown	GFEPAD...	48	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5826
P37108-81-unknown	MAYSNL...	81	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000453361
P37108-81-unknown	MAYSNL...	81	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452756

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KPIPKK	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10064
...KGTVEG	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5826
...ATAAQ	136	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAA_HUMAN	42	IPKK.\|.KGTV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATL1_HUMAN	47	TVEG.\|.GFEP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)