Q13620: Cullin-4B

General Information

Protein names	- Cullin-4B - CUL-4B
Gene names	CUL4B
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q13620

6 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cullin-4B - Isoform 3 of Cullin-4B

Sequence View

        10         20         30         40         50         60
MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP PTSAKKRKLN
        70         80         90        100        110        120
SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS FCLGVSVAAS SHVPIQKKLR
       130        140        150        160        170        180
FEDTLEFVGF DAKMAEESSS SSSSSSPTAA TSQQQQLKNK SILISSVASV HHANGLAKSS
       190        200        210        220        230        240
TTVSSFANSK PGSAKKLVIK NFKDKPKLPE NYTDETWQKL KEAVEAIQNS TSIKYNLEEL
       250        260        270        280        290        300
YQAVENLCSY KISANLYKQL RQICEDHIKA QIHQFREDSL DSVLFLKKID RCWQNHCRQM
       310        320        330        340        350        360
IMIRSIFLFL DRTYVLQNSM LPSIWDMGLE LFRAHIISDQ KVQNKTIDGI LLLIERERNG
       370        380        390        400        410        420
EAIDRSLLRS LLSMLSDLQI YQDSFEQRFL EETNRLYAAE GQKLMQEREV PEYLHHVNKR
       430        440        450        460        470        480
LEEEADRLIT YLDQTTQKSL IATVEKQLLG EHLTAILQKG LNNLLDENRI QDLSLLYQLF
       490        500        510        520        530        540
SRVRGGVQVL LQQWIEYIKA FGSTIVINPE KDKTMVQELL DFKDKVDHII DICFLKNEKF
       550        560        570        580        590        600
INAMKEAFET FINKRPNKPA ELIAKYVDSK LRAGNKEATD EELEKMLDKI MIIFRFIYGK
       610        620        630        640        650        660
DVFEAFYKKD LAKRLLVGKS ASVDAEKSML SKLKHECGAA FTSKLEGMFK DMELSKDIMI
       670        680        690        700        710        720
QFKQYMQNQN VPGNIELTVN ILTMGYWPTY VPMEVHLPPE MVKLQEIFKT FYLGKHSGRK
       730        740        750        760        770        780
LQWQSTLGHC VLKAEFKEGK KELQVSLFQT LVLLMFNEGE EFSLEEIKQA TGIEDGELRR
       790        800        810        820        830        840
TLQSLACGKA RVLAKNPKGK DIEDGDKFIC NDDFKHKLFR IKINQIQMKE TVEEQASTTE
       850        860        870        880        890        900
RVFQDRQYQI DAAIVRIMKM RKTLSHNLLV SEVYNQLKFP VKPADLKKRI ESLIDRDYME
       910
RDKENPNQYN YIA         10         20         30         40         50         60
MMSQSSGSGD GNDDEATTSK DGGFSSPSPS AAAAAQEVRS ATDGNTSTTP PTSAKKRKLN
        70         80         90        100        110        120
SSSSSSSNSS NEREDFDSTS SSSSTPPLQP RDSASPSTSS FCLGVSVAAS SHVPIQKKLR
       130        140        150        160        170        180
FEDTLEFVGF DAKMAEESSS SSSSSSPTAA TSQQQQLKNK SILISSVASV HHANGLAKSS
       190        200        210        220        230        240
TTVSSFANSK PGSAKKLVIK NFKDKPKLPE NYTDETWQKL KEAVEAIQNS TSIKYNLEEL
       250        260        270        280        290        300
YQAVENLCSY KISANLYKQL RQICEDHIKA QIHQFREDSL DSVLFLKKID RCWQNHCRQM
       310        320        330        340        350        360
IMIRSIFLFL DRTYVLQNSM LPSIWDMGLE LFRAHIISDQ KVQNKTIDGI LLLIERERNG
       370        380        390        400        410        420
EAIDRSLLRS LLSMLSDLQI YQDSFEQRFL EETNRLYAAE GQKLMQEREV PEYLHHVNKR
       430        440        450        460        470        480
LEEEADRLIT YLDQTTQKSL IATVEKQLLG EHLTAILQKG LNNLLDENRI QDLSLLYQLF
       490        500        510        520        530        540
SRVRGGVQVL LQQWIEYIKA FGSTIVINPE KDKTMVQELL DFKDKVDHII DICFLKNEKF
       550        560        570        580        590        600
INAMKEAFET FINKRPNKPA ELIAKYVDSK LRAGNKEATD EELEKMLDKI MIIFRFIYGK
       610        620        630        640        650        660
DVFEAFYKKD LAKRLLVGKS ASVDAEKSML SKLKHECGAA FTSKLEGMFK DMELSKDIMI
       670        680        690        700        710        720
QFKQYMQNQN VPGNIELTVN ILTMGYWPTY VPMEVHLPPE MVKLQEIFKT FYLGKHSGRK
       730        740        750        760        770        780
LQWQSTLGHC VLKAEFKEGK KELQVSLFQT LVLLMFNEGE EFSLEEIKQA TGIEDGELRR
       790        800        810        820        830        840
TLQSLACGKA RVLAKNPKGK DIEDGDKFIC NDDFKHKLFR IKINQIQMKE TVEEQASTTE
       850        860        870        880        890        900
RVFQDRQYQI DAAIVRIMKM RKTLSHNLLV SEVYNQLKFP VKPADLKKRI ESLIDRDYME
       910
RDKENPNQYN YIA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q13620-1-unknown	MMSQSS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q13620-1-acetylation	MMSQSS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q13620-26-unknown	SPSPSA...	26			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q13620-43-unknown	DGNTST...	43		inferred from electronic annotation	unknown	TISdb		inferred from TISdb
Q13620-44-	GNTSTT...	44			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q13620-44-	GNTSTT...	44			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q13620-503-unknown	STIVIN...	503		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6353
Q13620-503-unknown	STIVIN...	503		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150058

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...IKAFGS	502	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6353
...IKAFGS	502	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt133450
...ESLIDR	895		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ESLIDR	895		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...ESLIDR	895	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt143169
...YNYIA	913	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...YNYIA	913	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt67764

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	502	AFGS.\|.STIV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)