P53396: ATP-citrate synthase

General Information

Protein names	- ATP-citrate synthase - 2.3.3.8 {ECO:0000269\|PubMed:23932781} - ATP-citrate (pro-S-)-lyase - ACL - Citrate cleavage enzyme
Gene names	ACLY
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P53396

35 N-termini

15 C-termini

21 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of ATP-citrate synthase - Isoform 3 of ATP-citrate synthase

Sequence View

        10         20         30         40         50         60
MSAKAISEQT GKELLYKFIC TTSAIQNRFK YARVTPDTDW ARLLQDHPWL LSQNLVVKPD
        70         80         90        100        110        120
QLIKRRGKLG LVGVNLTLDG VKSWLKPRLG QEATVGKATG FLKNFLIEPF VPHSQAEEFY
       130        140        150        160        170        180
VCIYATREGD YVLFHHEGGV DVGDVDAKAQ KLLVGVDEKL NPEDIKKHLL VHAPEDKKEI
       190        200        210        220        230        240
LASFISGLFN FYEDLYFTYL EINPLVVTKD GVYVLDLAAK VDATADYICK VKWGDIEFPP
       250        260        270        280        290        300
PFGREAYPEE AYIADLDAKS GASLKLTLLN PKGRIWTMVA GGGASVVYSD TICDLGGVNE
       310        320        330        340        350        360
LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPDGKILII GGSIANFTNV AATFKGIVRA
       370        380        390        400        410        420
IRDYQGPLKE HEVTIFVRRG GPNYQEGLRV MGEVGKTTGI PIHVFGTETH MTAIVGMALG
       430        440        450        460        470        480
HRPIPNQPPT AAHTANFLLN ASGSTSTPAP SRTASFSESR ADEVAPAKKA KPAMPQDSVP
       490        500        510        520        530        540
SPRSLQGKST TLFSRHTKAI VWGMQTRAVQ GMLDFDYVCS RDEPSVAAMV YPFTGDHKQK
       550        560        570        580        590        600
FYWGHKEILI PVFKNMADAM RKHPEVDVLI NFASLRSAYD STMETMNYAQ IRTIAIIAEG
       610        620        630        640        650        660
IPEALTRKLI KKADQKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV
       670        680        690        700        710        720
SRSGGMSNEL NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV KMIVVLGEIG
       730        740        750        760        770        780
GTEEYKICRG IKEGRLTKPI VCWCIGTCAT MFSSEVQFGH AGACANQASE TAVAKNQALK
       790        800        810        820        830        840
EAGVFVPRSF DELGEIIQSV YEDLVANGVI VPAQEVPPPT VPMDYSWARE LGLIRKPASF
       850        860        870        880        890        900
MTSICDERGQ ELIYAGMPIT EVFKEEMGIG GVLGLLWFQK RLPKYSCQFI EMCLMVTADH
       910        920        930        940        950        960
GPAVSGAHNT IICARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV
       970        980        990       1000       1010       1020
NKMKKEGKLI MGIGHRVKSI NNPDMRVQIL KDYVRQHFPA TPLLDYALEV EKITTSKKPN
      1030       1040       1050       1060       1070       1080
LILNVDGLIG VAFVDMLRNC GSFTREEADE YIDIGALNGI FVLGRSMGFI GHYLDQKRLK
      1090       1100
QGLYRHPWDD ISYVLPEHMS M         10         20         30         40         50         60
MSAKAISEQT GKELLYKFIC TTSAIQNRFK YARVTPDTDW ARLLQDHPWL LSQNLVVKPD
        70         80         90        100        110        120
QLIKRRGKLG LVGVNLTLDG VKSWLKPRLG QEATVGKATG FLKNFLIEPF VPHSQAEEFY
       130        140        150        160        170        180
VCIYATREGD YVLFHHEGGV DVGDVDAKAQ KLLVGVDEKL NPEDIKKHLL VHAPEDKKEI
       190        200        210        220        230        240
LASFISGLFN FYEDLYFTYL EINPLVVTKD GVYVLDLAAK VDATADYICK VKWGDIEFPP
       250        260        270        280        290        300
PFGREAYPEE AYIADLDAKS GASLKLTLLN PKGRIWTMVA GGGASVVYSD TICDLGGVNE
       310        320        330        340        350        360
LANYGEYSGA PSEQQTYDYA KTILSLMTRE KHPDGKILII GGSIANFTNV AATFKGIVRA
       370        380        390        400        410        420
IRDYQGPLKE HEVTIFVRRG GPNYQEGLRV MGEVGKTTGI PIHVFGTETH MTAIVGMALG
       430        440        450        460        470        480
HRPIPNQPPT AAHTANFLLN ASGSTSTPAP SRTASFSESR ADEVAPAKKA KPAMPQDSVP
       490        500        510        520        530        540
SPRSLQGKST TLFSRHTKAI VWGMQTRAVQ GMLDFDYVCS RDEPSVAAMV YPFTGDHKQK
       550        560        570        580        590        600
FYWGHKEILI PVFKNMADAM RKHPEVDVLI NFASLRSAYD STMETMNYAQ IRTIAIIAEG
       610        620        630        640        650        660
IPEALTRKLI KKADQKGVTI IGPATVGGIK PGCFKIGNTG GMLDNILASK LYRPGSVAYV
       670        680        690        700        710        720
SRSGGMSNEL NNIISRTTDG VYEGVAIGGD RYPGSTFMDH VLRYQDTPGV KMIVVLGEIG
       730        740        750        760        770        780
GTEEYKICRG IKEGRLTKPI VCWCIGTCAT MFSSEVQFGH AGACANQASE TAVAKNQALK
       790        800        810        820        830        840
EAGVFVPRSF DELGEIIQSV YEDLVANGVI VPAQEVPPPT VPMDYSWARE LGLIRKPASF
       850        860        870        880        890        900
MTSICDERGQ ELIYAGMPIT EVFKEEMGIG GVLGLLWFQK RLPKYSCQFI EMCLMVTADH
       910        920        930        940        950        960
GPAVSGAHNT IICARAGKDL VSSLTSGLLT IGDRFGGALD AAAKMFSKAF DSGIIPMEFV
       970        980        990       1000       1010       1020
NKMKKEGKLI MGIGHRVKSI NNPDMRVQIL KDYVRQHFPA TPLLDYALEV EKITTSKKPN
      1030       1040       1050       1060       1070       1080
LILNVDGLIG VAFVDMLRNC GSFTREEADE YIDIGALNGI FVLGRSMGFI GHYLDQKRLK
      1090       1100
QGLYRHPWDD ISYVLPEHMS M

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

35 N-termini - 15 C-termini - 21 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P53396-1-unknown	MSAKAI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P53396-1-unknown	MSAKAI...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt66171
P53396-2-acetylation	SAKAIS...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P53396-2-acetylation	SAKAIS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182765
P53396-53-unknown	QNLVVK...	53		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7554
P53396-53-unknown	QNLVVK...	53		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139401
P53396-55-unknown	LVVKPD...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3846
P53396-55-unknown	LVVKPD...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17719
P53396-55-unknown	LVVKPD...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139491
P53396-297-	GVNELA...	297			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53396-297-unknown	GVNELA...	297		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177706
P53396-419-unknown	LGHRPI...	419		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3848
P53396-419-unknown	LGHRPI...	419		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152311
P53396-422-unknown	RPIPNQ...	422		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6007
P53396-422-unknown	RPIPNQ...	422		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152370
P53396-434-unknown	TANFLL...	434		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182767
P53396-434-	TANFLL...	434			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P53396-439-unknown	LNASGS...	439		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182769
P53396-439-	LNASGS...	439			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P53396-440-	NASGST...	440			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53396-440-unknown	NASGST...	440		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177708
P53396-441-	ASGSTS...	441			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P53396-441-	ASGSTS...	441			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P53396-441-	ASGSTS...	441			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P53396-441-	ASGSTS...	441			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53396-441-unknown	ASGSTS...	441		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3850
P53396-441-unknown	ASGSTS...	441		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7556
P53396-441-unknown	ASGSTS...	441			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53396-441-unknown	ASGSTS...	441		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152650
P53396-461-	ADEVAP...	461			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P53396-461-	ADEVAP...	461			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P53396-470-	AKPAMP...	470			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P53396-470-	AKPAMP...	470			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P53396-470-	AKPAMP...	470			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P53396-470-	AKPAMP...	470			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P53396-470-unknown	AKPAMP...	470			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53396-470-unknown	AKPAMP...	470			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P53396-484-unknown	SLQGKS...	484		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10097
P53396-577-	SAYDST...	577			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P53396-577-unknown	SAYDST...	577		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177704
P53396-625-unknown	TVGGIK...	625		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3852
P53396-625-unknown	TVGGIK...	625		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17721
P53396-625-unknown	TVGGIK...	625		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154831
P53396-626-unknown	VGGIKP...	626		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3854
P53396-626-unknown	VGGIKP...	626		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154848
P53396-628-unknown	GIKPGC...	628		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6009
P53396-628-unknown	GIKPGC...	628		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7558
P53396-628-unknown	GIKPGC...	628		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt154889
P53396-677-unknown	TTDGVY...	677		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182771
P53396-677-	TTDGVY...	677			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P53396-678-unknown	TDGVYE...	678		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182773
P53396-678-	TDGVYE...	678			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P53396-687-unknown	IGGDRY...	687		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6011
P53396-687-unknown	IGGDRY...	687		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7560
P53396-687-unknown	IGGDRY...	687		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155630
P53396-717-unknown	GEIGGT...	717		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6013
P53396-717-unknown	GEIGGT...	717		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt155914
P53396-760-unknown	HAGACA...	760		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3856
P53396-760-unknown	HAGACA...	760		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6015
P53396-760-unknown	HAGACA...	760		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7562
P53396-760-unknown	HAGACA...	760		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156268
P53396-770-Pyrrolidone carboxylic acid (Glu)	ETAVAK...	770	pyrrolidone carboxylic acid-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P53396-770-Pyrrolidone carboxylic acid (Glu)	ETAVAK...	770	pyrrolidone carboxylic acid-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182775
P53396-906-unknown	GAHNTI...	906		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7564
P53396-906-unknown	GAHNTI...	906		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt156857
P53396-1069-unknown	FIGHYL...	1069		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3858
P53396-1069-unknown	FIGHYL...	1069		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157279

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PWLLSQ	52	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7554
...PWLLSQ	52	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122482
...LLSQNL	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3846
...LLSQNL	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17719
...LLSQNL	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122581
...IVGMAL	418	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3848
...IVGMAL	418	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135722
...MALGHR	421	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6007
...MALGHR	421	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135781
...NFLLNA	440	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3850
...NFLLNA	440	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7556
...NFLLNA	440	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136068
...VPSPRS	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10097
...IIGPAT	624	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3852
...IIGPAT	624	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17721
...IIGPAT	624	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138258
...IGPATV	625	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3854
...IGPATV	625	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138275
...PATVGG	627	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6009
...PATVGG	627	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7558
...PATVGG	627	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138317
...YEGVAI	686	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6011
...YEGVAI	686	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7560
...YEGVAI	686	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139072
...MIVVLG	716	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6013
...MIVVLG	716	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139371
...EVQFGH	759	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3856
...EVQFGH	759	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6015
...EVQFGH	759	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7562
...EVQFGH	759	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt139738
...GPAVSG	905	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7564
...GPAVSG	905	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140354
...GRSMGF	1068	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3858
...GRSMGF	1068	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt140778
...EHMSM	1101	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EHMSM	1101	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61789

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	52	LLSQ.\|.QNLV	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	54	SQNL.\|.LVVK	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	54	SQNL.\|.LVVK	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	418	GMAL.\|.LGHR	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	421	LGHR.\|.RPIP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	440	LLNA.\|.ASGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	440	LLNA.\|.ASGS	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAA_HUMAN	483	SPRS.\|.SLQG	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
CATB_HUMAN	624	GPAT.\|.TVGG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	624	GPAT.\|.TVGG	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	625	PATV.\|.VGGI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	627	TVGG.\|.GIKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	627	TVGG.\|.GIKP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	686	GVAI.\|.IGGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	686	GVAI.\|.IGGD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	716	VVLG.\|.GEIG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	759	QFGH.\|.HAGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	759	QFGH.\|.HAGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	759	QFGH.\|.HAGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	905	AVSG.\|.GAHN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	1068	SMGF.\|.FIGH	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)