Q12904: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

General Information

Protein names	- Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 - Multisynthase complex auxiliary component p43 - Endothelial monocyte-activating polypeptide 2 - EMAP-2 - Endothelial monocyte-activating polypeptide II - EMAP-II - Small inducible cytokine subfamily E member 1
Gene names	AIMP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q12904

8 N-termini

6 C-termini

5 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MANNDAVLKR LEQKGAEADQ IIEYLKQQVS LLKEKAILQA TLREEKKLRV ENAKLKKEIE
        70         80         90        100        110        120
ELKQELIQAE IQNGVKQIPF PSGTPLHANS MVSENVIQST AVTTVSSGTK EQIKGGTGDE
       130        140        150        160        170        180
KKAKEKIEKK GEKKEKKQQS IAGSADSKPI DVSRLDLRIG CIITARKHPD ADSLYVEEVD
       190        200        210        220        230        240
VGEIAPRTVV SGLVNHVPLE QMQNRMVILL CNLKPAKMRG VLSQAMVMCA SSPEKIEILA
       250        260        270        280        290        300
PPNGSVPGDR ITFDAFPGEP DKELNPKKKI WEQIQPDLHT NDECVATYKG VPFEVKGKGV
       310
CRAQTMSNSG IK

Isoforms

- Isoform 2 of Aminoacyl tRNA synthase complex-interacting multifunctional protein 1

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q12904-1-unknown	MANNDA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt104577
Q12904-2-unknown	MANNDA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12904-2-Acetylation	ANNDAV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12904-2-Acetylation	ANNDAV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q12904-2-Acetylation	ANNDAV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q12904-2-Acetylation	ANNDAV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q12904-2-Acetylation	ANNDAV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111081
Q12904-143-unknown	GSADSK...	143		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7744
Q12904-143-unknown	GSADSK...	143		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145409
Q12904-147-unknown	SKPIDV...	147		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q12904-147-unknown	SKPIDV...	147		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt115955
Q12904-173-unknown	SLYVEE...	173		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11973
Q12904-173-unknown	SLYVEE...	173		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146503
Q12904-229-unknown	CASSPE...	229		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14386
Q12904-229-unknown	CASSPE...	229		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt148524
Q12904-255-unknown	AFPGEP...	255		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7746
Q12904-255-unknown	AFPGEP...	255		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6257
Q12904-255-unknown	AFPGEP...	255		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149313

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...QQSIAG	142	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7744
...QQSIAG	142	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt128702
...HPDADS	172	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11973
...HPDADS	172	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt129811
...QAMVMC	228	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14386
...QAMVMC	228	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt131898
...RITFDA	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7746
...RITFDA	254	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6257
...RITFDA	254	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132698
...NSGIK	312		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NSGIK	312		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...NSGIK	312	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...NSGIK	312	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt62199
...NSGIK	312		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NSGIK	312		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	142	SIAG.\|.GSAD	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	172	DADS.\|.SLYV	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
GRAM_HUMAN	228	MVMC.\|.CASS	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CATS_HUMAN	254	TFDA.\|.AFPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	254	TFDA.\|.AFPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)