P07437: Tubulin beta chain
Protein names | - Tubulin beta chain - Tubulin beta-5 chain |
---|---|
Gene names | TUBB |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P07437 |
54
N-termini
25
C-termini
28
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLDRISVY YNEATGGKYV
70 80 90 100 110 120
PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV
130 140 150 160 170 180
RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV
190 200 210 220 230 240
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL
250 260 270 280 290 300
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQVFDAKNMM
310 320 330 340 350 360
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG
370 380 390 400 410 420
LKMAVTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS
430 440
EYQQYQDATA EEEEDFGEEA EEEA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
54 N-termini - 25 C-termini - 28 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P07437-1-unknown | MREIVH... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P07437-9-unknown | AGQCGN... | 9 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7217 | |||
P07437-9-unknown | AGQCGN... | 9 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5438 | |||
P07437-20- | FWEVIS... | 20 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-20- | FWEVIS... | 20 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-25-unknown | SDEHGI... | 25 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15305 | |||
P07437-29- | GIDPTG... | 29 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-29- | GIDPTG... | 29 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P07437-29- | GIDPTG... | 29 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-29- | GIDPTG... | 29 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-35- | TYHGDS... | 35 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-40-unknown | SDLQLD... | 40 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11094 | |||
P07437-48-unknown | SVYYNE... | 48 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15306 | |||
P07437-48- | SVYYNE... | 48 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-48- | SVYYNE... | 48 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-48- | SVYYNE... | 48 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-48- | SVYYNE... | 48 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-49- | VYYNEA... | 49 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-49- | VYYNEA... | 49 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-52- | NEATGG... | 52 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-63-unknown | AILVDL... | 63 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9944 | |||
P07437-63- | AILVDL... | 63 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-63- | AILVDL... | 63 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-63- | AILVDL... | 63 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-63- | AILVDL... | 63 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-63- | AILVDL... | 63 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-67-unknown | DLEPGT... | 67 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15307 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000365578 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000379668 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000383375 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000383374 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000414479 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000394124 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000407673 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000392914 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000416480 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000393340 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000399046 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000406981 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000391515 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000394841 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000403213 | |||
P07437-73-unknown | MDSVRS... | 73 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000395838 | |||
P07437-78- | SGPFGQ... | 78 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-90- | FVFGQS... | 90 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-91- | VFGQSG... | 91 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-102-unknown | AKGHYT... | 102 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11095 | |||
P07437-102-unknown | AKGHYT... | 102 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15308 | |||
P07437-104- | GHYTEG... | 104 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-104- | GHYTEG... | 104 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-104- | GHYTEG... | 104 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-104- | GHYTEG... | 104 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-104- | GHYTEG... | 104 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-105- | HYTEGA... | 105 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-105- | HYTEGA... | 105 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P07437-105- | HYTEGA... | 105 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-105- | HYTEGA... | 105 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-108-unknown | EGAELV... | 108 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15309 | |||
P07437-114- | DSVLDV... | 114 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-115-unknown | SVLDVV... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5439 | |||
P07437-115-unknown | SVLDVV... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11096 | |||
P07437-115-unknown | SVLDVV... | 115 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1129 | |||
P07437-136-unknown | THSLGG... | 136 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15310 | |||
P07437-138- | SLGGGT... | 138 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-138- | SLGGGT... | 138 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-138- | SLGGGT... | 138 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-138- | SLGGGT... | 138 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-140-unknown | GGGTGS... | 140 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15311 | |||
P07437-141- | GGTGSG... | 141 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-141- | GGTGSG... | 141 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-164- | MNTFSV... | 164 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-164- | MNTFSV... | 164 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-164- | MNTFSV... | 164 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P07437-164- | MNTFSV... | 164 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-164- | MNTFSV... | 164 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-165- | NTFSVV... | 165 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-166- | TFSVVP... | 166 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-166- | TFSVVP... | 166 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-166- | TFSVVP... | 166 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-168- | SVVPSP... | 168 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-168- | SVVPSP... | 168 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P07437-168- | SVVPSP... | 168 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-206-unknown | ALYDIC... | 206 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11097 | |||
P07437-218-unknown | TTPTYG... | 218 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15312 | |||
P07437-222-unknown | YGDLNH... | 222 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15313 | |||
P07437-230-unknown | SATMSG... | 230 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15314 | |||
P07437-241-unknown | RFPGQL... | 241 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15315 | |||
P07437-252-unknown | KLAVNM... | 252 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9945 | |||
P07437-254-unknown | AVNMVP... | 254 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15316 | |||
P07437-254- | AVNMVP... | 254 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-254- | AVNMVP... | 254 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-257- | MVPFPR... | 257 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-264-unknown | HFFMPG... | 264 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15317 | |||
P07437-265- | FFMPGF... | 265 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P07437-265- | FFMPGF... | 265 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-265- | FFMPGF... | 265 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-283- | ALTVPE... | 283 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-283-unknown | ALTVPE... | 283 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9946 | |||
P07437-293-unknown | VFDAKN... | 293 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15318 | |||
P07437-300-unknown | MAACDP... | 300 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13928 | |||
P07437-303-unknown | CDPRHG... | 303 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13929 | |||
P07437-305-unknown | PRHGRY... | 305 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11098 | |||
P07437-321- | MSMKEV... | 321 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
P07437-322- | SMKEVD... | 322 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P07437-322- | SMKEVD... | 322 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P07437-322- | SMKEVD... | 322 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P07437-322- | SMKEVD... | 322 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-337- | NSSYFV... | 337 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P07437-338- | SSYFVE... | 338 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P07437-363- | MAVTFI... | 363 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...IVHIQA | 8 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7217 | |||
...IVHIQA | 8 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5438 | |||
...FWEVIS | 24 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15305 | |||
...TYHGDS | 39 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11094 | |||
...QLDRIS | 47 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15306 | |||
...KYVPRA | 62 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9944 | |||
...RAILVD | 66 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15307 | |||
...AGNNWA | 101 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11095 | |||
...AGNNWA | 101 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15308 | |||
...KGHYTE | 107 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15309 | |||
...AELVDS | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5439 | |||
...AELVDS | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11096 | |||
...AELVDS | 114 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1129 | |||
...QGFQLT | 135 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15310 | |||
...LTHSLG | 139 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15311 | |||
...CIDNEA | 205 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11097 | |||
...RTLKLT | 217 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15312 | |||
...LTTPTY | 221 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15313 | |||
...LNHLVS | 229 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15314 | |||
...VTTCLR | 240 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15315 | |||
...NADLRK | 251 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9945 | |||
...DLRKLA | 253 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15316 | |||
...PFPRLH | 263 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15317 | |||
...SQQYRA | 282 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9946 | |||
...ELTQQV | 292 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC15318 | |||
...DAKNMM | 299 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13928 | |||
...NMMAAC | 302 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13929 | |||
...MAACDP | 304 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC11098 | |||
...AEEEA | 444 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|