P30084: Enoyl-CoA hydratase, mitochondrial

General Information

Protein names	- Enoyl-CoA hydratase, mitochondrial - 4.2.1.17 {ECO:0000269\|PubMed:26251176} - Enoyl-CoA hydratase 1 - Short-chain enoyl-CoA hydratase - SCEH
Gene names	ECHS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30084

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAALRVLLSC VRGPLRPPVR CPAWRPFASG ANFEYIIAEK RGKNNTVGLI QLNRPKALNA
        70         80         90        100        110        120
LCDGLIDELN QALKTFEEDP AVGAIVLTGG DKAFAAGADI KEMQNLSFQD CYSSKFLKHW
       130        140        150        160        170        180
DHLTQVKKPV IAAVNGYAFG GGCELAMMCD IIYAGEKAQF AQPEILIGTI PGAGGTQRLT
       190        200        210        220        230        240
RAVGKSLAME MVLTGDRISA QDAKQAGLVS KICPVETLVE EAIQCAEKIA SNSKIVVAMA
       250        260        270        280        290
KESVNAAFEM TLTEGSKLEK KLFYSTFATD DRKEGMTAFV EKRKANFKDQ

Isoforms

Sequence View

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Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P30084-28-	ASGANF...	28		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P30084-28-unknown	ASGANF...	28	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30084-28-unknown	ASGANF...	28		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30084-28-unknown	ASGANF...	28		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30084-169-unknown	TIPGAG...	169	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5771

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...EILIGT	168	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5771
...NFKDQ	290	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...NFKDQ	290		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NFKDQ	290		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...NFKDQ	290		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...NFKDQ	290		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	168	LIGT.\|.TIPG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)