P30419: Glycylpeptide N-tetradecanoyltransferase 1

General Information

Protein names	- Glycylpeptide N-tetradecanoyltransferase 1 - 2.3.1.97 {ECO:0000269\|PubMed:22865860, ECO:0000269\|PubMed:25255805, ECO:0000269\|PubMed:9353336, ECO:0000269\|PubMed:9506952} - Myristoyl-CoA:protein N-myristoyltransferase 1 - NMT 1 - Type I N-myristoyltransferase - Peptide N-myristoyltransferase 1
Gene names	NMT1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P30419

8 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADESETAVK PPAPPLPQMM EGNGNGHEHC SDCENEEDNS YNRGGLSPAN DTGAKKKKKK
        70         80         90        100        110        120
QKKKKEKGSE TDSAQDQPVK MNSLPAERIQ EIQKAIELFS VGQGPAKTME EASKRSYQFW
       130        140        150        160        170        180
DTQPVPKLGE VVNTHGPVEP DKDNIRQEPY TLPQGFTWDA LDLGDRGVLK ELYTLLNENY
       190        200        210        220        230        240
VEDDDNMFRF DYSPEFLLWA LRPPGWLPQW HCGVRVVSSR KLVGFISAIP ANIHIYDTEK
       250        260        270        280        290        300
KMVEINFLCV HKKLRSKRVA PVLIREITRR VHLEGIFQAV YTAGVVLPKP VGTCRYWHRS
       310        320        330        340        350        360
LNPRKLIEVK FSHLSRNMTM QRTMKLYRLP ETPKTAGLRP METKDIPVVH QLLTRYLKQF
       370        380        390        400        410        420
HLTPVMSQEE VEHWFYPQEN IIDTFVVENA NGEVTDFLSF YTLPSTIMNH PTHKSLKAAY
       430        440        450        460        470        480
SFYNVHTQTP LLDLMSDALV LAKMKGFDVF NALDLMENKT FLEKLKFGIG DGNLQYYLYN
       490
WKCPSMGAEK VGLVLQ

Isoforms

- Isoform Short of Glycylpeptide N-tetradecanoyltransferase 1

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P30419-1-unknown	MADESE...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P30419-73-unknown	SAQDQP...	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC11438
P30419-73-unknown	SAQDQP...	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1778
P30419-81-unknown	MNSLPA...	81	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt82978
P30419-100-	SVGQGP...	100		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P30419-100-	SVGQGP...	100		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P30419-100-	SVGQGP...	100		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P30419-100-	SVGQGP...	100		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P30419-100-	SVGQGP...	100		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P30419-100-unknown	SVGQGP...	100		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30419-100-unknown	SVGQGP...	100		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30419-100-unknown	SVGQGP...	100	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159983
P30419-116-	SYQFWD...	116		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P30419-116-	SYQFWD...	116		Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P30419-116-	SYQFWD...	116		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P30419-116-	SYQFWD...	116		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P30419-116-unknown	SYQFWD...	116		unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P30419-116-unknown	SYQFWD...	116	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt159985
P30419-134-unknown	THGPVE...	134	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5777
P30419-134-unknown	THGPVE...	134	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3764
P30419-134-unknown	THGPVE...	134	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139465

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GSETDS	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC11438
...GSETDS	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1778
...GEVVNT	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5777
...GEVVNT	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3764
...GEVVNT	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122555
...GLVLQ	496	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GLVLQ	496	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78596

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAB_HUMAN	72	ETDS.\|.SAQD	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CASP3_HUMAN	72	ETDS.\|.SAQD	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> NMT1_HUMAN @72
CATL1_HUMAN	133	VVNT.\|.THGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	133	VVNT.\|.THGP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)