P45974: Ubiquitin carboxyl-terminal hydrolase 5
Protein names | - Ubiquitin carboxyl-terminal hydrolase 5 - 3.4.19.12 - Deubiquitinating enzyme 5 - Isopeptidase T - Ubiquitin thioesterase 5 - Ubiquitin-specific-processing protease 5 |
---|---|
Gene names | USP5 |
Organism | Homo sapiens |
Protease Family | C19.001 |
Protease ID | C19.001 |
Chromosome location | |
UniProt ID | P45974 |
20
N-termini
2
C-termini
1
Cleavages
1
Substrates
Sequence
10 20 30 40 50 60
MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER
70 80 90 100 110 120
HFNKTGQRVY LHLRRTRRPK EEDPATGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV
130 140 150 160 170 180
KIVILPDYLE IARDGLGGLP DIVRDRVTSA VEALLSADSA SRKQEVQAWD GEVRQVSKHA
190 200 210 220 230 240
FSLKQLDNPA RIPPCGWKCS KCDMRENLWL NLTDGSILCG RRYFDGSGGN NHAVEHYRET
250 260 270 280 290 300
GYPLAVKLGT ITPDGADVYS YDEDDMVLDP SLAEHLSHFG IDMLKMQKTD KTMTELEIDM
310 320 330 340 350 360
NQRIGEWELI QESGVPLKPL FGPGYTGIRN LGNSCYLNSV VQVLFSIPDF QRKYVDKLEK
370 380 390 400 410 420
IFQNAPTDPT QDFSTQVAKL GHGLLSGEYS KPVPESGDGE RVPEQKEVQD GIAPRMFKAL
430 440 450 460 470 480
IGKGHPEFST NRQQDAQEFF LHLINMVERN CRSSENPNEV FRFLVEEKIK CLATEKVKYT
490 500 510 520 530 540
QRVDYIMQLP VPMDAALNKE ELLEYEEKKR QAEEEKMALP ELVRAQVPFS SCLEAYGAPE
550 560 570 580 590 600
QVDDFWSTAL QAKSVAVKTT RFASFPDYLV IQIKKFTFGL DWVPKKLDVS IEMPEELDIS
610 620 630 640 650 660
QLRGTGLQPG EEELPDIAPP LVTPDEPKGS LGFYGNEDED SFCSPHFSSP TSPMLDESVI
670 680 690 700 710 720
IQLVEMGFPM DACRKAVYYT GNSGAEAAMN WVMSHMDDPD FANPLILPGS SGPGSTSAAA
730 740 750 760 770 780
DPPPEDCVTT IVSMGFSRDQ ALKALRATNN SLERAVDWIF SHIDDLDAEA AMDISEGRSA
790 800 810 820 830 840
ADSISESVPV GPKVRDGPGK YQLFAFISHM GTSTMCGHYV CHIKKEGRWV IYNDQKVCAS
850
EKPPKDLGYI YFYQRVAS
Isoforms
- Isoform Short of Ubiquitin carboxyl-terminal hydrolase 5Sequence View
10 20 30 40 50 60
MAELSEEALL SVLPTIRVPK AGDRVHKDEC AFSFDTPESE GGLYICMNTF LGFGKQYVER
70 80 90 100 110 120
HFNKTGQRVY LHLRRTRRPK EEDPATGTGD PPRKKPTRLA IGVEGGFDLS EEKFELDEDV
130 140 150 160 170 180
KIVILPDYLE IARDGLGGLP DIVRDRVTSA VEALLSADSA SRKQEVQAWD GEVRQVSKHA
190 200 210 220 230 240
FSLKQLDNPA RIPPCGWKCS KCDMRENLWL NLTDGSILCG RRYFDGSGGN NHAVEHYRET
250 260 270 280 290 300
GYPLAVKLGT ITPDGADVYS YDEDDMVLDP SLAEHLSHFG IDMLKMQKTD KTMTELEIDM
310 320 330 340 350 360
NQRIGEWELI QESGVPLKPL FGPGYTGIRN LGNSCYLNSV VQVLFSIPDF QRKYVDKLEK
370 380 390 400 410 420
IFQNAPTDPT QDFSTQVAKL GHGLLSGEYS KPVPESGDGE RVPEQKEVQD GIAPRMFKAL
430 440 450 460 470 480
IGKGHPEFST NRQQDAQEFF LHLINMVERN CRSSENPNEV FRFLVEEKIK CLATEKVKYT
490 500 510 520 530 540
QRVDYIMQLP VPMDAALNKE ELLEYEEKKR QAEEEKMALP ELVRAQVPFS SCLEAYGAPE
550 560 570 580 590 600
QVDDFWSTAL QAKSVAVKTT RFASFPDYLV IQIKKFTFGL DWVPKKLDVS IEMPEELDIS
610 620 630 640 650 660
QLRGTGLQPG EEELPDIAPP LVTPDEPKGS LGFYGNEDED SFCSPHFSSP TSPMLDESVI
670 680 690 700 710 720
IQLVEMGFPM DACRKAVYYT GNSGAEAAMN WVMSHMDDPD FANPLILPGS SGPGSTSAAA
730 740 750 760 770 780
DPPPEDCVTT IVSMGFSRDQ ALKALRATNN SLERAVDWIF SHIDDLDAEA AMDISEGRSA
790 800 810 820 830 840
ADSISESVPV GPKVRDGPGK YQLFAFISHM GTSTMCGHYV CHIKKEGRWV IYNDQKVCAS
850
EKPPKDLGYI YFYQRVAS
Protein Neighborhood
Domains & Features
20 N-termini - 2 C-termini - 1 Cleavages - 1 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P45974-2-unknown | MAELSE... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P45974-1-unknown | MAELSE... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt93737 | |||
P45974-2-Acetylation | AELSEE... | 2 | acetylation- | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | ||
P45974-2-Acetylation | AELSEE... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: Complementary positional proteomics for screening substrates... | 20526345 | ||
P45974-2-Acetylation | AELSEE... | 2 | acetylation- | other | CNRS/ISV | Large_scale_NTA_Human | |||
P45974-2-Acetylation | AELSEE... | 2 | acetylation- | COFRADIC | Gevaert K. | Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates... | 20526345 | ||
P45974-2-Acetylation | AELSEE... | 2 | acetylation- | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt110533 | ||
P45974-134-unknown | DGLGGL... | 134 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt182720 | |||
P45974-134- | DGLGGL... | 134 | N-TAILS | Overall Laboratory | Lange_Huesgen_et_al-RBC | ||||
P45974-135-unknown | GLGGLP... | 135 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt175193 | |||
P45974-135- | GLGGLP... | 135 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P45974-135- | GLGGLP... | 135 | Subtiligase Based Positive Selection | Wells | apoptotic_RPMI_Dox | 23264352 | |||
P45974-391-unknown | KPVPES... | 391 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5879 | |||
P45974-391-unknown | KPVPES... | 391 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt151864 | |||
P45974-399- | GERVPE... | 399 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P45974-399- | GERVPE... | 399 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P45974-399-unknown | GERVPE... | 399 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt176685 | |||
P45974-768- | AEAAMD... | 768 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P45974-768- | AEAAMD... | 768 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P45974-768- | AEAAMD... | 768 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P45974-768- | AEAAMD... | 768 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P45974-768- | AEAAMD... | 768 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P45974-768-unknown | AEAAMD... | 768 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P45974-768-unknown | AEAAMD... | 768 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162280 | |||
P45974-770- | AAMDIS... | 770 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P45974-770- | AAMDIS... | 770 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P45974-770-unknown | AAMDIS... | 770 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt170523 | |||
P45974-779-unknown | SAADSI... | 779 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177812 | |||
P45974-779- | SAADSI... | 779 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P45974-783-unknown | SISESV... | 783 | unknown | Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
P45974-783-unknown | SISESV... | 783 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt162282 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | DB_Untreated | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptotic_DB_Doxo | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_Etoposide | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1s_bort | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | MM1SDBJurkat_Untreated | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
P45974-783- | SISESV... | 783 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 | |||
P45974-787-unknown | SVPVGP... | 787 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt177814 | |||
P45974-787- | SVPVGP... | 787 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...SGEYSK | 390 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5879 | |||
...SGEYSK | 390 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt135270 | |||
...QRVAS | 858 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...QRVAS | 858 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt89355 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CATL1_HUMAN | 390 | EYSK.|.KPVP | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
UBC_HUMAN | 76 | RGGM.|.MQIF | inferred from experiment | unknown | MEROPS | Merops UBP5_HUMAN -> UBC_HUMAN @76 |