P0CG48: Polyubiquitin-C

General Information

Protein names	- Polyubiquitin-C - Ubiquitin
Gene names	UBC
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P0CG48

26 N-termini

28 C-termini

41 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN
        70         80         90        100        110        120
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI
       130        140        150        160        170        180
FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA
       190        200        210        220        230        240
KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGMQ IFVKTLTGKT
       250        260        270        280        290        300
ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED GRTLSDYNIQ KESTLHLVLR
       310        320        330        340        350        360
LRGGMQIFVK TLTGKTITLE VEPSDTIENV KAKIQDKEGI PPDQQRLIFA GKQLEDGRTL
       370        380        390        400        410        420
SDYNIQKEST LHLVLRLRGG MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ
       430        440        450        460        470        480
QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE
       490        500        510        520        530        540
NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL
       550        560        570        580        590        600
TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH
       610        620        630        640        650        660
LVLRLRGGMQ IFVKTLTGKT ITLEVEPSDT IENVKAKIQD KEGIPPDQQR LIFAGKQLED
       670        680
GRTLSDYNIQ KESTLHLVLR LRGGV

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

26 N-termini - 28 C-termini - 41 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P0CG48-1-unknown	MQIFVK...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-17-unknown	VEPSDT...	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17266
P0CG48-73-unknown	LRGGMQ...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15768
P0CG48-75-unknown	GGMQIF...	75	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15769
P0CG48-77-unknown	MQIFVK...	77	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8457
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32049
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32051
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32052
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32053
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32054
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32055
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32056
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32057
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32058
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32059
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32060
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32061
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32062
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32063
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32064
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32065
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32066
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32067
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32097
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC610
P0CG48-77-unknown	MQIFVK...	77	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31621
P0CG48-149-unknown	LRGGMQ...	149	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15770
P0CG48-151-unknown	GGMQIF...	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15771
P0CG48-153-unknown	MQIFVK...	153	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-225-unknown	LRGGMQ...	225	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15772
P0CG48-227-unknown	GGMQIF...	227	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15773
P0CG48-229-unknown	MQIFVK...	229	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-301-unknown	LRGGMQ...	301	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15774
P0CG48-303-unknown	GGMQIF...	303	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15775
P0CG48-305-unknown	MQIFVK...	305	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-377-unknown	LRGGMQ...	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15776
P0CG48-379-unknown	GGMQIF...	379	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15777
P0CG48-381-unknown	MQIFVK...	381	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-453-unknown	LRGGMQ...	453	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15778
P0CG48-455-unknown	GGMQIF...	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15779
P0CG48-457-unknown	MQIFVK...	457	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-529-unknown	LRGGMQ...	529	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15780
P0CG48-531-unknown	GGMQIF...	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15781
P0CG48-533-unknown	MQIFVK...	533	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P0CG48-605-unknown	LRGGMQ...	605	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15782
P0CG48-607-unknown	GGMQIF...	607	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15783
P0CG48-609-unknown	MQIFVK...	609	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TITLEV	16	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17266
...HLVLRL	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15768
...VLRLRG	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15769
...RLRGGM	76	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8457
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32049
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32051
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32052
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32053
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32054
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32055
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32056
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32057
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32058
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32059
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32060
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32061
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32062
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32063
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32064
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32065
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32066
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32067
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32097
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC610
...RLRGGM	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31621
...HLVLRL	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15770
...VLRLRG	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15771
...RLRGGM	152	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	224	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15772
...VLRLRG	226	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15773
...RLRGGM	228	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	300	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15774
...VLRLRG	302	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15775
...RLRGGM	304	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	376	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15776
...VLRLRG	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15777
...RLRGGM	380	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	452	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15778
...VLRLRG	454	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15779
...RLRGGM	456	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	528	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15780
...VLRLRG	530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15781
...RLRGGM	532	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	604	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15782
...VLRLRG	606	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15783
...RLRGGM	608	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...HLVLRL	680	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15784
...VLRLRG	682	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15785
...RLRGGV	684	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1A_HUMAN	16	TLEV.\|.VEPS	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
IDE_HUMAN	72	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	74	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS		Merops IDE_HUMAN -> UBC_HUMAN @74
CYLD_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Courtois G	Kovalenko A et al.:The tumour suppressor CYLD nega... (C67.001)	12917691,
UBP15_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS		Merops UBP15_HUMAN -> UBC_HUMAN @76
UBP2_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Chung CH	Baek SH et al.:Molecular cloning of a novel ub... (C19.013)	9325273,
UBP30_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP34_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP35_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP36_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP37_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP42_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP38_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP44_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP45_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP46_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP49_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP4_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Mayer RJ	Layfield R et al.:Chemically synthesized ubiquiti... (C19.010)	10527495,
UBP51_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,
UBP5_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS		Merops UBP5_HUMAN -> UBC_HUMAN @76
UBP7_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Mayer RJ	Layfield R et al.:Chemically synthesized ubiquiti... (C19.016)	10527495,
UBP8_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Urbe S	McCullough J et al.:AMSH is an endosome-associated ... (M67.006)	15314065,
USP9Y_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Rhee K	Lee KH et al.:Ubiquitin-specific protease act... (C19.028)	12895410,
BAP1_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Wilson AC	Misaghi S et al.:Association of C-terminal ubiqu... (C12.004)	19188440,
STABP_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Urbe S	McCullough J et al.:AMSH is an endosome-associated ... (M67.006)	15314065,
IDE_HUMAN	148	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	150	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	224	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	226	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	300	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	302	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	376	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	378	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	452	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	454	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	528	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	530	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	604	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	606	RLRG.\|.GGMQ	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	680	VLRL.\|.LRGG	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,
IDE_HUMAN	682	RLRG.\|.GGV	inferred from experiment	unknown	MEROPS	Tang WJ	Ralat LA et al.:Ubiquitin is a novel substrate ... (M16.002)	21185309,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)