TopFIND 4.0

Q9P2H5: Ubiquitin carboxyl-terminal hydrolase 35

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 35
- 3.4.19.12
- Deubiquitinating enzyme 35
- Ubiquitin thioesterase 35
- Ubiquitin-specific-processing protease 35
Gene names USP35
Organism Homo sapiens
Protease Family C19.059
Protease ID C19.059
Chromosome location
UniProt ID Q9P2H5

2

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MDKILEAVVT SSYPVSVKQG LVRRVLEAAR QPLEREQCLA LLALGARLYV GGAEELPRRV 
        70         80         90        100        110        120 
GCQLLHVAGR HHPDVFAEFF SARRVLRLLQ GGAGPPGPRA LACVQLGLQL LPEGPAADEV 
       130        140        150        160        170        180 
FALLRREVLR TVCERPGPAA CAQVARLLAR HPRCVPDGPH RLLFCQQLVR CLGRFRCPAE 
       190        200        210        220        230        240 
GEEGAVEFLE QAQQVSGLLA QLWRAQPAAI LPCLKELFAV ISCAEEEPPS SALASVVQHL 
       250        260        270        280        290        300 
PLELMDGVVR NLSNDDSVTD SQMLTAISRM IDWVSWPLGK NIDKWIIALL KGLAAVKKFS 
       310        320        330        340        350        360 
ILIEVSLTKI EKVFSKLLYP IVRGAALSVL KYMLLTFQHS HEAFHLLLPH IPPMVASLVK 
       370        380        390        400        410        420 
EDSNSGTSCL EQLAELVHCM VFRFPGFPDL YEPVMEAIKD LHVPNEDRIK QLLGQDAWTS 
       430        440        450        460        470        480 
QKSELAGFYP RLMAKSDTGK IGLINLGNTC YVNSILQALF MASDFRHCVL RLTENNSQPL 
       490        500        510        520        530        540 
MTKLQWLFGF LEHSQRPAIS PENFLSASWT PWFSPGTQQD CSEYLKYLLD RLHEEEKTGT 
       550        560        570        580        590        600 
RICQKLKQSS SPSPPEEPPA PSSTSVEKMF GGKIVTRICC LCCLNVSSRE EAFTDLSLAF 
       610        620        630        640        650        660 
PPPERCRRRR LGSVMRPTED ITARELPPPT SAQGPGRVGP RRQRKHCITE DTPPTSLYIE 
       670        680        690        700        710        720 
GLDSKEAGGQ SSQEERIERE EEGKEERTEK EEVGEEEEST RGEGEREKEE EVEEEEEKVE 
       730        740        750        760        770        780 
KETEKEAEQE KEEDSLGAGT HPDAAIPSGE RTCGSEGSRS VLDLVNYFLS PEKLTAENRY 
       790        800        810        820        830        840 
YCESCASLQD AEKVVELSQG PCYLILTLLR FSFDLRTMRR RKILDDVSIP LLLRLPLAGG 
       850        860        870        880        890        900 
RGQAYDLCSV VVHSGVSSES GHYYCYAREG AARPAASLGT ADRPEPENQW YLFNDTRVSF 
       910        920        930        940        950        960 
SSFESVSNVT SFFPKDTAYV LFYRQRPREG PEAELGSSRV RTEPTLHKDL MEAISKDNIL 
       970        980        990       1000       1010    
YLQEQEKEAR SRAAYISALP TSPHWGRGFD EDKDEDEGSP GGCNPAGGNG GDFHRLVF

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 35

Sequence View

        10         20         30         40         50         60 
MDKILEAVVT SSYPVSVKQG LVRRVLEAAR QPLEREQCLA LLALGARLYV GGAEELPRRV 
        70         80         90        100        110        120 
GCQLLHVAGR HHPDVFAEFF SARRVLRLLQ GGAGPPGPRA LACVQLGLQL LPEGPAADEV 
       130        140        150        160        170        180 
FALLRREVLR TVCERPGPAA CAQVARLLAR HPRCVPDGPH RLLFCQQLVR CLGRFRCPAE 
       190        200        210        220        230        240 
GEEGAVEFLE QAQQVSGLLA QLWRAQPAAI LPCLKELFAV ISCAEEEPPS SALASVVQHL 
       250        260        270        280        290        300 
PLELMDGVVR NLSNDDSVTD SQMLTAISRM IDWVSWPLGK NIDKWIIALL KGLAAVKKFS 
       310        320        330        340        350        360 
ILIEVSLTKI EKVFSKLLYP IVRGAALSVL KYMLLTFQHS HEAFHLLLPH IPPMVASLVK 
       370        380        390        400        410        420 
EDSNSGTSCL EQLAELVHCM VFRFPGFPDL YEPVMEAIKD LHVPNEDRIK QLLGQDAWTS 
       430        440        450        460        470        480 
QKSELAGFYP RLMAKSDTGK IGLINLGNTC YVNSILQALF MASDFRHCVL RLTENNSQPL 
       490        500        510        520        530        540 
MTKLQWLFGF LEHSQRPAIS PENFLSASWT PWFSPGTQQD CSEYLKYLLD RLHEEEKTGT 
       550        560        570        580        590        600 
RICQKLKQSS SPSPPEEPPA PSSTSVEKMF GGKIVTRICC LCCLNVSSRE EAFTDLSLAF 
       610        620        630        640        650        660 
PPPERCRRRR LGSVMRPTED ITARELPPPT SAQGPGRVGP RRQRKHCITE DTPPTSLYIE 
       670        680        690        700        710        720 
GLDSKEAGGQ SSQEERIERE EEGKEERTEK EEVGEEEEST RGEGEREKEE EVEEEEEKVE 
       730        740        750        760        770        780 
KETEKEAEQE KEEDSLGAGT HPDAAIPSGE RTCGSEGSRS VLDLVNYFLS PEKLTAENRY 
       790        800        810        820        830        840 
YCESCASLQD AEKVVELSQG PCYLILTLLR FSFDLRTMRR RKILDDVSIP LLLRLPLAGG 
       850        860        870        880        890        900 
RGQAYDLCSV VVHSGVSSES GHYYCYAREG AARPAASLGT ADRPEPENQW YLFNDTRVSF 
       910        920        930        940        950        960 
SSFESVSNVT SFFPKDTAYV LFYRQRPREG PEAELGSSRV RTEPTLHKDL MEAISKDNIL 
       970        980        990       1000       1010    
YLQEQEKEAR SRAAYISALP TSPHWGRGFD EDKDEDEGSP GGCNPAGGNG GDFHRLVF



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9P2H5-1-unknown MDKILE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9P2H5-270-unknown MIDWVS... 270 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93688

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...HRLVF 1018 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...HRLVF 1018 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt89306

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates