O75604: Ubiquitin carboxyl-terminal hydrolase 2

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 2 - 3.4.19.12 - 41 kDa ubiquitin-specific protease - Deubiquitinating enzyme 2 - Ubiquitin thioesterase 2 - Ubiquitin-specific-processing protease 2
Gene names	USP2
Organism	Homo sapiens
Protease Family	C19.013
Protease ID	C19.013
Chromosome location
UniProt ID	O75604

1 N-termini

3 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL
        70         80         90        100        110        120
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN
       130        140        150        160        170        180
CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC
       190        200        210        220        230        240
TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG
       250        260        270        280        290        300
KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY
       310        320        330        340        350        360
MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE
       370        380        390        400        410        420
FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK
       430        440        450        460        470        480
SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR
       490        500        510        520        530        540
GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV
       550        560        570        580        590        600
YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS

PPSRM

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 2 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 2 - Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 2

Sequence View

        10         20         30         40         50         60
MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL
        70         80         90        100        110        120
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN
       130        140        150        160        170        180
CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC
       190        200        210        220        230        240
TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG
       250        260        270        280        290        300
KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY
       310        320        330        340        350        360
MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE
       370        380        390        400        410        420
FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK
       430        440        450        460        470        480
SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR
       490        500        510        520        530        540
GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV
       550        560        570        580        590        600
YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS

PPSRM         10         20         30         40         50         60
MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL
        70         80         90        100        110        120
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN
       130        140        150        160        170        180
CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC
       190        200        210        220        230        240
TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG
       250        260        270        280        290        300
KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY
       310        320        330        340        350        360
MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE
       370        380        390        400        410        420
FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK
       430        440        450        460        470        480
SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR
       490        500        510        520        530        540
GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV
       550        560        570        580        590        600
YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS

PPSRM         10         20         30         40         50         60
MSQLSSTLKR YTESARYTDA HYAKSGYGAY TPSSYGANLA ASLLEKEKLG FKPVPTSSFL
        70         80         90        100        110        120
TRPRTYGPSS LLDYDRGRPL LRPDITGGGK RAESQTRGTE RPLGSGLSGG SGFPYGVTNN
       130        140        150        160        170        180
CLSYLPINAY DQGVTLTQKL DSQSDLARDF SSLRTSDSYR IDPRNLGRSP MLARTRKELC
       190        200        210        220        230        240
TLQGLYQTAS CPEYLVDYLE NYGRKGSASQ VPSQAPPSRV PEIISPTYRP IGRYTLWETG
       250        260        270        280        290        300
KGQAPGPSRS SSPGRDGMNS KSAQGLAGLR NLGNTCFMNS ILQCLSNTRE LRDYCLQRLY
       310        320        330        340        350        360
MRDLHHGSNA HTALVEEFAK LIQTIWTSSP NDVVSPSEFK TQIQRYAPRF VGYNQQDAQE
       370        380        390        400        410        420
FLRFLLDGLH NEVNRVTLRP KSNPENLDHL PDDEKGRQMW RKYLEREDSR IGDLFVGQLK
       430        440        450        460        470        480
SSLTCTDCGY CSTVFDPFWD LSLPIAKRGY PEVTLMDCMR LFTKEDVLDG DEKPTCCRCR
       490        500        510        520        530        540
GRKRCIKKFS IQRFPKILVL HLKRFSESRI RTSKLTTFVN FPLRDLDLRE FASENTNHAV
       550        560        570        580        590        600
YNLYAVSNHS GTTMGGHYTA YCRSPGTGEW HTFNDSSVTP MSSSQVRTSD AYLLFYELAS

PPSRM

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVTLTQ	137	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431857
...PRNLGR	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433977
...PPSRM	605	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PPSRM	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89291
...PPSRM	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89292
...PPSRM	605	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89293

TopFIND

O75604: Ubiquitin carboxyl-terminal hydrolase 2

General Information

1

N-termini

3

C-termini

0

Cleavages

1

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

1 N-termini - 3 C-termini - 0 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

Substrates