Q93009: Ubiquitin carboxyl-terminal hydrolase 7

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 7 - 3.4.19.12 {ECO:0000269\|PubMed:11923872, ECO:0000269\|PubMed:12507430, ECO:0000269\|PubMed:14506283, ECO:0000269\|PubMed:15053880, ECO:0000269\|PubMed:16964248, ECO:0000269\|PubMed:18716620, ECO:0000269\|PubMed:21745816} - Deubiquitinating enzyme 7 - Herpesvirus-associated ubiquitin-specific protease - Ubiquitin thioesterase 7 - Ubiquitin-specific-processing protease 7
Gene names	USP7
Organism	Homo sapiens
Protease Family	C19.016
Protease ID	C19.016
Chromosome location
UniProt ID	Q93009

7 N-termini

6 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MNHQQQQQQQ KAGEQQLSEP EDMEMEAGDT DDPPRITQNP VINGNVALSD GHNTAEEDME
        70         80         90        100        110        120
DDTSWRSEAT FQFTVERFSR LSESVLSPPC FVRNLPWKIM VMPRFYPDRP HQKSVGFFLQ
       130        140        150        160        170        180
CNAESDSTSW SCHAQAVLKI INYRDDEKSF SRRISHLFFH KENDWGFSNF MAWSEVTDPE
       190        200        210        220        230        240
KGFIDDDKVT FEVFVQADAP HGVAWDSKKH TGYVGLKNQG ATCYMNSLLQ TLFFTNQLRK
       250        260        270        280        290        300
AVYMMPTEGD DSSKSVPLAL QRVFYELQHS DKPVGTKKLT KSFGWETLDS FMQHDVQELC
       310        320        330        340        350        360
RVLLDNVENK MKGTCVEGTI PKLFRGKMVS YIQCKEVDYR SDRREDYYDI QLSIKGKKNI
       370        380        390        400        410        420
FESFVDYVAV EQLDGDNKYD AGEHGLQEAE KGVKFLTLPP VLHLQLMRFM YDPQTDQNIK
       430        440        450        460        470        480
INDRFEFPEQ LPLDEFLQKT DPKDPANYIL HAVLVHSGDN HGGHYVVYLN PKGDGKWCKF
       490        500        510        520        530        540
DDDVVSRCTK EEAIEHNYGG HDDDLSVRHC TNAYMLVYIR ESKLSEVLQA VTDHDIPQQL
       550        560        570        580        590        600
VERLQEEKRI EAQKRKERQE AHLYMQVQIV AEDQFCGHQG NDMYDEEKVK YTVFKVLKNS
       610        620        630        640        650        660
SLAEFVQSLS QTMGFPQDQI RLWPMQARSN GTKRPAMLDN EADGNKTMIE LSDNENPWTI
       670        680        690        700        710        720
FLETVDPELA ASGATLPKFD KDHDVMLFLK MYDPKTRSLN YCGHIYTPIS CKIRDLLPVM
       730        740        750        760        770        780
CDRAGFIQDT SLILYEEVKP NLTERIQDYD VSLDKALDEL MDGDIIVFQK DDPENDNSEL
       790        800        810        820        830        840
PTAKEYFRDL YHRVDVIFCD KTIPNDPGFV VTLSNRMNYF QVAKTVAQRL NTDPMLLQFF
       850        860        870        880        890        900
KSQGYRDGPG NPLRHNYEGT LRDLLQFFKP RQPKKLYYQQ LKMKITDFEN RRSFKCIWLN
       910        920        930        940        950        960
SQFREEEITL YPDKHGCVRD LLEECKKAVE LGEKASGKLR LLEIVSYKII GVHQEDELLE
       970        980        990       1000       1010       1020
CLSPATSRTF RIEEIPLDQV DIDKENEMLV TVAHFHKEVF GTFGIPFLLR IHQGEHFREV
      1030       1040       1050       1060       1070       1080
MKRIQSLLDI QEKEFEKFKF AIVMMGRHQY INEDEYEVNL KDFEPQPGNM SHPRPWLGLD
      1090       1100
HFNKAPKRSR YTYLEKAIKI HN

Isoforms

- Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 7

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 6 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q93009-1-unknown	MNHQQQ...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q93009-1-acetylation	MNHQQQ...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q93009-23-acetylation	MEMEAG...	23	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q93009-51-	GHNTAE...	51			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q93009-51-	GHNTAE...	51			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q93009-51-	GHNTAE...	51			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q93009-51-	GHNTAE...	51			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q93009-51-	GHNTAE...	51			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q93009-51-unknown	GHNTAE...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt171162
Q93009-59-unknown	MEDDTS...	59		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000456150
Q93009-59-unknown	MEDDTS...	59		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000457237
Q93009-59-unknown	MEDDTS...	59		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000457815
Q93009-59-unknown	MEDDTS...	59		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196301
Q93009-100-unknown	MVMPRF...	100		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000454795
Q93009-100-unknown	MVMPRF...	100		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443646
Q93009-100-unknown	MVMPRF...	100		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196954

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...NDWGFS	167	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457815
...NDWGFS	167	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155219
...NFMAWS	173	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000455719
...NFMAWS	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155305
...MAWSEV	175	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000457237
...MAWSEV	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155327
...IDDDKV	188	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000456150
...IDDDKV	188	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155488
...GIPFLL	1008	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000454795
...IKIHN	1102	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...IKIHN	1102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt89358

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
UBC_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Mayer RJ	Layfield R et al.:Chemically synthesized ubiquiti... (C19.016)	10527495,