TopFIND 4.0

Q8NB14: Ubiquitin carboxyl-terminal hydrolase 38

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 38
- 3.4.19.12
- Deubiquitinating enzyme 38
- HP43.8KD
- Ubiquitin thioesterase 38
- Ubiquitin-specific-processing protease 38
Gene names USP38
Organism Homo sapiens
Protease Family C19.056
Protease ID C19.056
Chromosome location
UniProt ID Q8NB14

1

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MDKILEGLVS SSHPLPLKRV IVRKVVESAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 
        70         80         90        100        110        120 
GHQVLEAYAR YHRPEFESFF NKTFVLGLLH QGYHSLDRKD VAILDYIHNG LKLIMSCPSV 
       130        140        150        160        170        180 
LDLFSLLQVE VLRMVCERPE PQLCARLSDL LTDFVQCIPK GKLSITFCQQ LVRTIGHFQC 
       190        200        210        220        230        240 
VSTQERELRE YVSQVTKVSN LLQNIWKAEP ATLLPSLQEV FASISSTDAS FEPSVALASL 
       250        260        270        280        290        300 
VQHIPLQMIT VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV 
       310        320        330        340        350        360 
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHL IVPHVVNLVH 
       370        380        390        400        410        420 
SFKNDGLPSS TAFLVQLTEL IHCMMYHYSG FPDLYEPILE AIKDFPKPSE EKIKLILNQS 
       430        440        450        460        470        480 
AWTSQSNSLA SCLSRLSGKS ETGKTGLINL GNTCYMNSVI QALFMATDFR RQVLSLNLNG 
       490        500        510        520        530        540 
CNSLMKKLQH LFAFLAHTQR EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE 
       550        560        570        580        590        600 
KILKVQASHK PSEILECSET SLQEVASKAA VLTETPRTSD GEKTLIEKMF GGKLRTHIRC 
       610        620        630        640        650        660 
LNCRSTSQKV EAFTDLSLAF CPSSSLENMS VQDPASSPSI QDGGLMQASV PGPSEEPVVY 
       670        680        690        700        710        720 
NPTTAAFICD SLVNEKTIGS PPNEFYCSEN TSVPNESNKI LVNKDVPQKP GGETTPSVTD 
       730        740        750        760        770        780 
LLNYFLAPEI LTGDNQYYCE NCASLQNAEK TMQITEEPEY LILTLLRFSY DQKYHVRRKI 
       790        800        810        820        830        840 
LDNVSLPLVL ELPVKRITSF SSLSESWSVD VDFTDLSENL AKKLKPSGTD EASCTKLVPY 
       850        860        870        880        890        900 
LLSSVVVHSG ISSESGHYYS YARNITSTDS SYQMYHQSEA LALASSQSHL LGRDSPSAVF 
       910        920        930        940        950        960 
EQDLENKEMS KEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQH STNGLSGNNP 
       970        980        990       1000       1010       1020 
TSGLWINGDP PLQKELMDAI TKDNKLYLQE QELNARARAL QAASASCSFR PNGFDDNDPP 
      1030       1040    
GSCGPTGGGG GGGFNTVGRL VF

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 38

Sequence View

        10         20         30         40         50         60 
MDKILEGLVS SSHPLPLKRV IVRKVVESAE HWLDEAQCEA MFDLTTRLIL EGQDPFQRQV 
        70         80         90        100        110        120 
GHQVLEAYAR YHRPEFESFF NKTFVLGLLH QGYHSLDRKD VAILDYIHNG LKLIMSCPSV 
       130        140        150        160        170        180 
LDLFSLLQVE VLRMVCERPE PQLCARLSDL LTDFVQCIPK GKLSITFCQQ LVRTIGHFQC 
       190        200        210        220        230        240 
VSTQERELRE YVSQVTKVSN LLQNIWKAEP ATLLPSLQEV FASISSTDAS FEPSVALASL 
       250        260        270        280        290        300 
VQHIPLQMIT VLIRSLTTDP NVKDASMTQA LCRMIDWLSW PLAQHVDTWV IALLKGLAAV 
       310        320        330        340        350        360 
QKFTILIDVT LLKIELVFNR LWFPLVRPGA LAVLSHMLLS FQHSPEAFHL IVPHVVNLVH 
       370        380        390        400        410        420 
SFKNDGLPSS TAFLVQLTEL IHCMMYHYSG FPDLYEPILE AIKDFPKPSE EKIKLILNQS 
       430        440        450        460        470        480 
AWTSQSNSLA SCLSRLSGKS ETGKTGLINL GNTCYMNSVI QALFMATDFR RQVLSLNLNG 
       490        500        510        520        530        540 
CNSLMKKLQH LFAFLAHTQR EAYAPRIFFE ASRPPWFTPR SQQDCSEYLR FLLDRLHEEE 
       550        560        570        580        590        600 
KILKVQASHK PSEILECSET SLQEVASKAA VLTETPRTSD GEKTLIEKMF GGKLRTHIRC 
       610        620        630        640        650        660 
LNCRSTSQKV EAFTDLSLAF CPSSSLENMS VQDPASSPSI QDGGLMQASV PGPSEEPVVY 
       670        680        690        700        710        720 
NPTTAAFICD SLVNEKTIGS PPNEFYCSEN TSVPNESNKI LVNKDVPQKP GGETTPSVTD 
       730        740        750        760        770        780 
LLNYFLAPEI LTGDNQYYCE NCASLQNAEK TMQITEEPEY LILTLLRFSY DQKYHVRRKI 
       790        800        810        820        830        840 
LDNVSLPLVL ELPVKRITSF SSLSESWSVD VDFTDLSENL AKKLKPSGTD EASCTKLVPY 
       850        860        870        880        890        900 
LLSSVVVHSG ISSESGHYYS YARNITSTDS SYQMYHQSEA LALASSQSHL LGRDSPSAVF 
       910        920        930        940        950        960 
EQDLENKEMS KEWFLFNDSR VTFTSFQSVQ KITSRFPKDT AYVLLYKKQH STNGLSGNNP 
       970        980        990       1000       1010       1020 
TSGLWINGDP PLQKELMDAI TKDNKLYLQE QELNARARAL QAASASCSFR PNGFDDNDPP 
      1030       1040    
GSCGPTGGGG GGGFNTVGRL VF



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q8NB14-1-unknown MDKILE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q8NB14-1-unknown MDKILE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93692

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...GRLVF 1042 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates