Q92560: Ubiquitin carboxyl-terminal hydrolase BAP1 {ECO:0000305}

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase BAP1 {ECO:0000305} - 3.4.19.12 {ECO:0000269\|PubMed:20436459, ECO:0000269\|PubMed:9528852} - BRCA1-associated protein 1 {ECO:0000303\|PubMed:9528852} - Cerebral protein 6 {ECO:0000303\|Ref.2}
Gene names	BAP1
Organism	Homo sapiens
Protease Family	C12.004
Protease ID	C12.004
Chromosome location
UniProt ID	Q92560

3 N-termini

2 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MNKGWLELES DPGLFTLLVE DFGVKGVQVE EIYDLQSKCQ GPVYGFIFLF KWIEERRSRR
        70         80         90        100        110        120
KVSTLVDDTS VIDDDIVNNM FFAHQLIPNS CATHALLSVL LNCSSVDLGP TLSRMKDFTK
       130        140        150        160        170        180
GFSPESKGYA IGNAPELAKA HNSHARPEPR HLPEKQNGLS AVRTMEAFHF VSYVPITGRL
       190        200        210        220        230        240
FELDGLKVYP IDHGPWGEDE EWTDKARRVI MERIGLATAG EPYHDIRFNL MAVVPDRRIK
       250        260        270        280        290        300
YEARLHVLKV NRQTVLEALQ QLIRVTQPEL IQTHKSQESQ LPEESKSASN KSPLVLEANR
       310        320        330        340        350        360
APAASEGNHT DGAEEAAGSC AQAPSHSPPN KPKLVVKPPG SSLNGVHPNP TPIVQRLPAF
       370        380        390        400        410        420
LDNHNYAKSP MQEEEDLAAG VGRSRVPVRP PQQYSDDEDD YEDDEEDDVQ NTNSALRYKG
       430        440        450        460        470        480
KGTGKPGALS GSADGQLSVL QPNTINVLAE KLKESQKDLS IPLSIKTSSG AGSPAVAVPT
       490        500        510        520        530        540
HSQPSPTPSN ESTDTASEIG SAFNSPLRSP IRSANPTRPS SPVTSHISKV LFGEDDSLLR
       550        560        570        580        590        600
VDCIRYNRAV RDLGPVISTG LLHLAEDGVL SPLALTEGGK GSSPSIRPIQ GSQGSSSPVE
       610        620        630        640        650        660
KEVVEATDSR EKTGMVRPGE PLSGEKYSPK ELLALLKCVE AEIANYEACL KEEVEKRKKF
       670        680        690        700        710        720
KIDDQRRTHN YDEFICTFIS MLAQEGMLAN LVEQNISVRR RQGVSIGRLH KQRKPDRRKR

SRPYKAKRQ

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q92560-1-unknown	MNKGWL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q92560-80-unknown	MFFAHQ...	80	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417776
Q92560-500-unknown	GSAFNS...	500	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420647

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KVYPID	191	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000417776
	...KAKRQ	729	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
UBC_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Wilson AC	Misaghi S et al.:Association of C-terminal ubiqu... (C12.004)	19188440,