TopFIND 4.0

P62068: Ubiquitin carboxyl-terminal hydrolase 46

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 46
- 3.4.19.12 {ECO:0000269|PubMed:14715245, ECO:0000269|PubMed:19075014, ECO:0000269|PubMed:26388029}
- Deubiquitinating enzyme 46
- Ubiquitin thioesterase 46
- Ubiquitin-specific-processing protease 46
Gene names USP46
Organism Homo sapiens
Protease Family C19.052
Protease ID C19.052
Chromosome location
UniProt ID P62068

2

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 
        70         80         90        100        110        120 
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 
       130        140        150        160        170        180 
AHEFLNYLLN TIADILQEEK KQEKQNGKLK NGNMNEPAEN NKPELTWVHE IFQGTLTNET 
       190        200        210        220        230        240 
RCLNCETVSS KDEDFLDLSV DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK 
       250        260        270        280        290        300 
RMRVKKLPMI LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA 
       310        320        330        340        350        360 
VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI SKNSESGYIL 
   
FYQSRE

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 46 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 46 - Isoform 4 of Ubiquitin carboxyl-terminal hydrolase 46

Sequence View

        10         20         30         40         50         60 
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 
        70         80         90        100        110        120 
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 
       130        140        150        160        170        180 
AHEFLNYLLN TIADILQEEK KQEKQNGKLK NGNMNEPAEN NKPELTWVHE IFQGTLTNET 
       190        200        210        220        230        240 
RCLNCETVSS KDEDFLDLSV DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK 
       250        260        270        280        290        300 
RMRVKKLPMI LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA 
       310        320        330        340        350        360 
VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI SKNSESGYIL 
   
FYQSRE         10         20         30         40         50         60 
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 
        70         80         90        100        110        120 
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 
       130        140        150        160        170        180 
AHEFLNYLLN TIADILQEEK KQEKQNGKLK NGNMNEPAEN NKPELTWVHE IFQGTLTNET 
       190        200        210        220        230        240 
RCLNCETVSS KDEDFLDLSV DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK 
       250        260        270        280        290        300 
RMRVKKLPMI LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA 
       310        320        330        340        350        360 
VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI SKNSESGYIL 
   
FYQSRE         10         20         30         40         50         60 
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL QALYFCRPFR 
        70         80         90        100        110        120 
ENVLAYKAQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK KFISRLRKEN DLFDNYMQQD 
       130        140        150        160        170        180 
AHEFLNYLLN TIADILQEEK KQEKQNGKLK NGNMNEPAEN NKPELTWVHE IFQGTLTNET 
       190        200        210        220        230        240 
RCLNCETVSS KDEDFLDLSV DVEQNTSITH CLRDFSNTET LCSEQKYYCE TCCSKQEAQK 
       250        260        270        280        290        300 
RMRVKKLPMI LALHLKRFKY MEQLHRYTKL SYRVVFPLEL RLFNTSSDAV NLDRMYDLVA 
       310        320        330        340        350        360 
VVVHCGSGPN RGHYITIVKS HGFWLLFDDD IVEKIDAQAI EEFYGLTSDI SKNSESGYIL 
   
FYQSRE



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates