TopFIND 4.0

Q70CQ1: Ubiquitin carboxyl-terminal hydrolase 49

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 49
- 3.4.19.12
- Deubiquitinating enzyme 49
- Ubiquitin thioesterase 49
- Ubiquitin-specific-processing protease 49
Gene names USP49
Organism Homo sapiens
Protease Family C19.073
Protease ID C19.073
Chromosome location
UniProt ID Q70CQ1

1

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE 
        70         80         90        100        110        120 
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDTP VRRGRTLRSM 
       130        140        150        160        170        180 
ASGEDVVLPQ RAPQGQPQML TALWYRRQRL LARTLRLWFE KSSRGQAKLE QRRQEEALER 
       190        200        210        220        230        240 
KKEEARRRRR EVKRRLLEEL ASTPPRKSAR LLLHTPRDAG PAASRPAALP TSRRVPAATL 
       250        260        270        280        290        300 
KLRRQPAMAP GVTGLRNLGN TCYMNSILQV LSHLQKFREC FLNLDPSKTE HLFPKATNGK 
       310        320        330        340        350        360 
TQLSGKPTNS SATELSLRND RAEACEREGF CWNGRASISR SLELIQNKEP SSKHISLCRE 
       370        380        390        400        410        420 
LHTLFRVMWS GKWALVSPFA MLHSVWSLIP AFRGYDQQDA QEFLCELLHK VQQELESEGT 
       430        440        450        460        470        480 
TRRILIPFSQ RKLTKQVLKV VNTIFHGQLL SQVTCISCNY KSNTIEPFWD LSLEFPERYH 
       490        500        510        520        530        540 
CIEKGFVPLN QTECLLTEML AKFTETEALE GRIYACDQCN SKRRKSNPKP LVLSEARKQL 
       550        560        570        580        590        600 
MIYRLPQVLR LHLKRFRWSG RNHREKIGVH VVFDQVLTME PYCCRDMLSS LDKETFAYDL 
       610        620        630        640        650        660 
SAVVMHHGKG FGSGHYTAYC YNTEGGFWVH CNDSKLNVCS VEEVCKTQAY ILFYTQRTVQ 
       670        680    
GNARISETHL QAQVQSSNND EGRPQTFS

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 49

Sequence View

        10         20         30         40         50         60 
MDRCKHVGRL RLAQDHSILN PQKWCCLECA TTESVWACLK CSHVACGRYI EDHALKHFEE 
        70         80         90        100        110        120 
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDTP VRRGRTLRSM 
       130        140        150        160        170        180 
ASGEDVVLPQ RAPQGQPQML TALWYRRQRL LARTLRLWFE KSSRGQAKLE QRRQEEALER 
       190        200        210        220        230        240 
KKEEARRRRR EVKRRLLEEL ASTPPRKSAR LLLHTPRDAG PAASRPAALP TSRRVPAATL 
       250        260        270        280        290        300 
KLRRQPAMAP GVTGLRNLGN TCYMNSILQV LSHLQKFREC FLNLDPSKTE HLFPKATNGK 
       310        320        330        340        350        360 
TQLSGKPTNS SATELSLRND RAEACEREGF CWNGRASISR SLELIQNKEP SSKHISLCRE 
       370        380        390        400        410        420 
LHTLFRVMWS GKWALVSPFA MLHSVWSLIP AFRGYDQQDA QEFLCELLHK VQQELESEGT 
       430        440        450        460        470        480 
TRRILIPFSQ RKLTKQVLKV VNTIFHGQLL SQVTCISCNY KSNTIEPFWD LSLEFPERYH 
       490        500        510        520        530        540 
CIEKGFVPLN QTECLLTEML AKFTETEALE GRIYACDQCN SKRRKSNPKP LVLSEARKQL 
       550        560        570        580        590        600 
MIYRLPQVLR LHLKRFRWSG RNHREKIGVH VVFDQVLTME PYCCRDMLSS LDKETFAYDL 
       610        620        630        640        650        660 
SAVVMHHGKG FGSGHYTAYC YNTEGGFWVH CNDSKLNVCS VEEVCKTQAY ILFYTQRTVQ 
       670        680    
GNARISETHL QAQVQSSNND EGRPQTFS



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q70CQ1-1-unknown MDRCKH... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q70CQ1-1-unknown MDRCKH... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93724

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PQTFS 688 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates