Q9P275: Ubiquitin carboxyl-terminal hydrolase 36 {ECO:0000305}

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 36 {ECO:0000305} - 3.4.19.12 - Deubiquitinating enzyme 36 - Ubiquitin thioesterase 36 - Ubiquitin-specific-processing protease 36
Gene names	USP36
Organism	Homo sapiens
Protease Family	C19.042
Protease ID	C19.042
Chromosome location
UniProt ID	Q9P275

6 N-termini

1 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MPIVDKLKEA LKPGRKDSAD DGELGKLLAS SAKKVLLQKI EFEPASKSFS YQLEALKSKY
        70         80         90        100        110        120
VLLNPKTEGA SRHKSGDDPP ARRQGSEHTY ESCGDGVPAP QKVLFPTERL SLRWERVFRV
       130        140        150        160        170        180
GAGLHNLGNT CFLNATIQCL TYTPPLANYL LSKEHARSCH QGSFCMLCVM QNHIVQAFAN
       190        200        210        220        230        240
SGNAIKPVSF IRDLKKIARH FRFGNQEDAH EFLRYTIDAM QKACLNGCAK LDRQTQATTL
       250        260        270        280        290        300
VHQIFGGYLR SRVKCSVCKS VSDTYDPYLD VALEIRQAAN IVRALELFVK ADVLSGENAY
       310        320        330        340        350        360
MCAKCKKKVP ASKRFTIHRT SNVLTLSLKR FANFSGGKIT KDVGYPEFLN IRPYMSQNNG
       370        380        390        400        410        420
DPVMYGLYAV LVHSGYSCHA GHYYCYVKAS NGQWYQMNDS LVHSSNVKVV LNQQAYVLFY
       430        440        450        460        470        480
LRIPGSKKSP EGLISRTGSS SLPGRPSVIP DHSKKNIGNG IISSPLTGKR QDSGTMKKPH
       490        500        510        520        530        540
TTEEIGVPIS RNGSTLGLKS QNGCIPPKLP SGSPSPKLSQ TPTHMPTILD DPGKKVKKPA
       550        560        570        580        590        600
PPQHFSPRTA QGLPGTSNSN SSRSGSQRQG SWDSRDVVLS TSPKLLATAT ANGHGLKGND
       610        620        630        640        650        660
ESAGLDRRGS SSSSPEHSAS SDSTKAPQTP RSGAAHLCDS QETNCSTAGH SKTPPSGADS
       670        680        690        700        710        720
KTVKLKSPVL SNTTTEPAST MSPPPAKKLA LSAKKASTLW RATGNDLRPP PPSPSSDLTH
       730        740        750        760        770        780
PMKTSHPVVA STWPVHRARA VSPAPQSSSR LQPPFSPHPT LLSSTPKPPG TSEPRSCSSI
       790        800        810        820        830        840
STALPQVNED LVSLPHQLPE ASEPPQSPSE KRKKTFVGEP QRLGSETRLP QHIREATAAP
       850        860        870        880        890        900
HGKRKRKKKK RPEDTAASAL QEGQTQRQPG SPMYRREGQA QLPAVRRQED GTQPQVNGQQ
       910        920        930        940        950        960
VGCVTDGHHA SSRKRRRKGA EGLGEEGGLH QDPLRHSCSP MGDGDPEAME ESPRKKKKKK
       970        980        990       1000       1010       1020
RKQETQRAVE EDGHLKCPRS AKPQDAVVPE SSSCAPSANG WCPGDRMGLS QAPPVSWNGE
      1030       1040       1050       1060       1070       1080
RESDVVQELL KYSSDKAYGR KVLTWDGKMS AVSQDAIEDS RQARTETVVD DWDEEFDRGK
      1090       1100       1110       1120
EKKIKKFKRE KRRNFNAFQK LQTRRNFWSV THPAKAASLS YRR

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 36

Sequence View

        10         20         30         40         50         60
MPIVDKLKEA LKPGRKDSAD DGELGKLLAS SAKKVLLQKI EFEPASKSFS YQLEALKSKY
        70         80         90        100        110        120
VLLNPKTEGA SRHKSGDDPP ARRQGSEHTY ESCGDGVPAP QKVLFPTERL SLRWERVFRV
       130        140        150        160        170        180
GAGLHNLGNT CFLNATIQCL TYTPPLANYL LSKEHARSCH QGSFCMLCVM QNHIVQAFAN
       190        200        210        220        230        240
SGNAIKPVSF IRDLKKIARH FRFGNQEDAH EFLRYTIDAM QKACLNGCAK LDRQTQATTL
       250        260        270        280        290        300
VHQIFGGYLR SRVKCSVCKS VSDTYDPYLD VALEIRQAAN IVRALELFVK ADVLSGENAY
       310        320        330        340        350        360
MCAKCKKKVP ASKRFTIHRT SNVLTLSLKR FANFSGGKIT KDVGYPEFLN IRPYMSQNNG
       370        380        390        400        410        420
DPVMYGLYAV LVHSGYSCHA GHYYCYVKAS NGQWYQMNDS LVHSSNVKVV LNQQAYVLFY
       430        440        450        460        470        480
LRIPGSKKSP EGLISRTGSS SLPGRPSVIP DHSKKNIGNG IISSPLTGKR QDSGTMKKPH
       490        500        510        520        530        540
TTEEIGVPIS RNGSTLGLKS QNGCIPPKLP SGSPSPKLSQ TPTHMPTILD DPGKKVKKPA
       550        560        570        580        590        600
PPQHFSPRTA QGLPGTSNSN SSRSGSQRQG SWDSRDVVLS TSPKLLATAT ANGHGLKGND
       610        620        630        640        650        660
ESAGLDRRGS SSSSPEHSAS SDSTKAPQTP RSGAAHLCDS QETNCSTAGH SKTPPSGADS
       670        680        690        700        710        720
KTVKLKSPVL SNTTTEPAST MSPPPAKKLA LSAKKASTLW RATGNDLRPP PPSPSSDLTH
       730        740        750        760        770        780
PMKTSHPVVA STWPVHRARA VSPAPQSSSR LQPPFSPHPT LLSSTPKPPG TSEPRSCSSI
       790        800        810        820        830        840
STALPQVNED LVSLPHQLPE ASEPPQSPSE KRKKTFVGEP QRLGSETRLP QHIREATAAP
       850        860        870        880        890        900
HGKRKRKKKK RPEDTAASAL QEGQTQRQPG SPMYRREGQA QLPAVRRQED GTQPQVNGQQ
       910        920        930        940        950        960
VGCVTDGHHA SSRKRRRKGA EGLGEEGGLH QDPLRHSCSP MGDGDPEAME ESPRKKKKKK
       970        980        990       1000       1010       1020
RKQETQRAVE EDGHLKCPRS AKPQDAVVPE SSSCAPSANG WCPGDRMGLS QAPPVSWNGE
      1030       1040       1050       1060       1070       1080
RESDVVQELL KYSSDKAYGR KVLTWDGKMS AVSQDAIEDS RQARTETVVD DWDEEFDRGK
      1090       1100       1110       1120
EKKIKKFKRE KRRNFNAFQK LQTRRNFWSV THPAKAASLS YRR

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9P275-1-unknown	MPIVDK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9P275-1-unknown	MPIVDK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93689
Q9P275-2-unknown	PIVDKL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9P275-2-unknown	PIVDKL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163075
Q9P275-96-unknown	GVPAPQ...	96	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168294
Q9P275-96-	GVPAPQ...	96		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9P275-96-	GVPAPQ...	96		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q9P275-96-	GVPAPQ...	96		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q9P275-96-	GVPAPQ...	96		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9P275-577-unknown	VVLSTS...	577		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9P275-577-unknown	VVLSTS...	577	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162274
Q9P275-577-	VVLSTS...	577		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...ASLSYR	1121	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...ASLSYR	1121	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt89307

TopFIND

Q9P275: Ubiquitin carboxyl-terminal hydrolase 36 {ECO:0000305}

General Information

6

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

6 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

Substrates