Q70CQ3: Ubiquitin carboxyl-terminal hydrolase 30

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 30 - 3.4.19.12 {ECO:0000269\|PubMed:14715245} - Deubiquitinating enzyme 30 - Ubiquitin thioesterase 30 - Ubiquitin-specific-processing protease 30 - Ub-specific protease 30
Gene names	USP30
Organism	Homo sapiens
Protease Family	C19.060
Protease ID	C19.060
Chromosome location
UniProt ID	Q70CQ3

4 N-termini

4 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MLSSRAEAAM TAADRAIQRF LRTGAAVRYK VMKNWGVIGG IAAALAAGIY VIWGPITERK
        70         80         90        100        110        120
KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIRWLEEFT SQYSRDQKEP PSHQYLSLTL
       130        140        150        160        170        180
LHLLKALSCQ EVTDDEVLDA SCLLDVLRMY RWQISSFEEQ DAHELFHVIT SSLEDERDRQ
       190        200        210        220        230        240
PRVTHLFDVH SLEQQSEITP KQITCRTRGS PHPTSNHWKS QHPFHGRLTS NMVCKHCEHQ
       250        260        270        280        290        300
SPVRFDTFDS LSLSIPAATW GHPLTLDHCL HHFISSESVR DVVCDNCTKI EAKGTLNGEK
       310        320        330        340        350        360
VEHQRTTFVK QLKLGKLPQC LCIHLQRLSW SSHGTPLKRH EHVQFNEFLM MDIYKYHLLG
       370        380        390        400        410        420
HKPSQHNPKL NKNPGPTLEL QDGPGAPTPV LNQPGAPKTQ IFMNGACSPS LLPTLSAPMP
       430        440        450        460        470        480
FPLPVVPDYS SSTYLFRLMA VVVHHGDMHS GHFVTYRRSP PSARNPLSTS NQWLWVSDDT
       490        500        510
VRKASLQEVL SSSAYLLFYE RVLSRMQHQS QECKSEE

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 0 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q70CQ3-1-unknown	MLSSRA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q70CQ3-32-unknown	MKNWGV...	32	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000376535
Q70CQ3-32-unknown	MKNWGV...	32	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000443678
Q70CQ3-385-	GAPTPV...	385		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q70CQ3-385-	GAPTPV...	385		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q70CQ3-385-unknown	GAPTPV...	385		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SLTLLH	121	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000440837
...ITCRTR	207	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000438829
...TCRTRG	208	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000443678
...CKSEE	517	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
UBC_HUMAN	76	RGGM.\|.MQIF	inferred from experiment	unknown	MEROPS	Lopez-Otin C	Quesada V et al.:Cloning and enzymatic analysis ... (C19.060)	14715245,