TopFIND 4.0

Q9NQC7: Ubiquitin carboxyl-terminal hydrolase CYLD

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase CYLD
- 3.4.19.12 {ECO:0000269|PubMed:18313383, ECO:0000269|PubMed:27458237, ECO:0000269|PubMed:27591049}
- Deubiquitinating enzyme CYLD
- Ubiquitin thioesterase CYLD
- Ubiquitin-specific-processing protease CYLD
Gene names CYLD
Organism Homo sapiens
Protease Family C67.001
Protease ID C67.001
Chromosome location
UniProt ID Q9NQC7

4

N-termini

2

C-termini

1

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 
        70         80         90        100        110        120 
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 
       130        140        150        160        170        180 
KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV 
       190        200        210        220        230        240 
YQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV 
       250        260        270        280        290        300 
GETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN 
       310        320        330        340        350        360 
DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN RSELFYTLNG 
       370        380        390        400        410        420 
SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP PLQPPPVNSL TTENRFHSLP 
       430        440        450        460        470        480 
FSLTKMPNTN GSIGHSPLSL SAQSVMEELN TAPVQESPPL AMPPGNSHGL EVGSLAEVKE 
       490        500        510        520        530        540 
NPPFYGVIRW IGQPPGLNEV LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR 
       550        560        570        580        590        600 
PDSRFASLQP VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS 
       610        620        630        640        650        660 
CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI YGYVCATKIM 
       670        680        690        700        710        720 
KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL KIRSAGQKVQ DCYFYQIFME 
       730        740        750        760        770        780 
KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS CLIIQMPRFG KDFKLFKKIF PSLELNITDL 
       790        800        810        820        830        840 
LEDTPRQCRI CGGLAMYECR ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL 
       850        860        870        880        890        900 
PKDLPDWDWR HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG 
       910        920        930        940        950    
FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP TMSLYK

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase CYLD

Sequence View

        10         20         30         40         50         60 
MSSGLWSQEK VTSPYWEERI FYLLLQECSV TDKQTQKLLK VPKGSIGQYI QDRSVGHSRI 
        70         80         90        100        110        120 
PSAKGKKNQI GLKILEQPHA VLFVDEKDVV EINEKFTELL LAITNCEERF SLFKNRNRLS 
       130        140        150        160        170        180 
KGLQIDVGCP VKVQLRSGEE KFPGVVRFRG PLLAERTVSG IFFGVELLEE GRGQGFTDGV 
       190        200        210        220        230        240 
YQGKQLFQCD EDCGVFVALD KLELIEDDDT ALESDYAGPG DTMQVELPPL EINSRVSLKV 
       250        260        270        280        290        300 
GETIESGTVI FCDVLPGKES LGYFVGVDMD NPIGNWDGRF DGVQLCSFAC VESTILLHIN 
       310        320        330        340        350        360 
DIIPALSESV TQERRPPKLA FMSRGVGDKG SSSHNKPKAT GSTSDPGNRN RSELFYTLNG 
       370        380        390        400        410        420 
SSVDSQPQSK SKNTWYIDEV AEDPAKSLTE ISTDFDRSSP PLQPPPVNSL TTENRFHSLP 
       430        440        450        460        470        480 
FSLTKMPNTN GSIGHSPLSL SAQSVMEELN TAPVQESPPL AMPPGNSHGL EVGSLAEVKE 
       490        500        510        520        530        540 
NPPFYGVIRW IGQPPGLNEV LAGLELEDEC AGCTDGTFRG TRYFTCALKK ALFVKLKSCR 
       550        560        570        580        590        600 
PDSRFASLQP VSNQIERCNS LAFGGYLSEV VEENTPPKME KEGLEIMIGK KKGIQGHYNS 
       610        620        630        640        650        660 
CYLDSTLFCL FAFSSVLDTV LLRPKEKNDV EYYSETQELL RTEIVNPLRI YGYVCATKIM 
       670        680        690        700        710        720 
KLRKILEKVE AASGFTSEEK DPEEFLNILF HHILRVEPLL KIRSAGQKVQ DCYFYQIFME 
       730        740        750        760        770        780 
KNEKVGVPTI QQLLEWSFIN SNLKFAEAPS CLIIQMPRFG KDFKLFKKIF PSLELNITDL 
       790        800        810        820        830        840 
LEDTPRQCRI CGGLAMYECR ECYDDPDISA GKIKQFCKTC NTQVHLHPKR LNHKYNPVSL 
       850        860        870        880        890        900 
PKDLPDWDWR HGCIPCQNME LFAVLCIETS HYVAFVKYGK DDSAWLFFDS MADRDGGQNG 
       910        920        930        940        950    
FNIPQVTPCP EVGEYLKMSL EDLHSLDSRR IQGCARRLLC DAYMCMYQSP TMSLYK



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(REFRESH)

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

Substrates