TopFIND 4.0

Q70EL2: Ubiquitin carboxyl-terminal hydrolase 45

General Information

Protein names
- Ubiquitin carboxyl-terminal hydrolase 45
- 3.4.19.12
- Deubiquitinating enzyme 45
- Ubiquitin thioesterase 45
- Ubiquitin-specific-processing protease 45
Gene names USP45
Organism Homo sapiens
Protease Family C19.064
Protease ID C19.064
Chromosome location
UniProt ID Q70EL2

1

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MRVKDPTKAL PEKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 
        70         80         90        100        110        120 
VCSECLKERR FYDGQLVLTS DIWLCLKCGF QGCGKNSESQ HSLKHFKSSR TEPHCIIINL 
       130        140        150        160        170        180 
STWIIWCYEC DEKLSTHCNK KVLAQIVDFL QKHASKTQTS AFSRIMKLCE EKCETDEIQK 
       190        200        210        220        230        240 
GGKCRNLSVR GITNLGNTCF FNAVMQNLAQ TYTLTDLMNE IKESSTKLKI FPSSDSQLDP 
       250        260        270        280        290        300 
LVVELSRPGP LTSALFLFLH SMKETEKGPL SPKVLFNQLC QKAPRFKDFQ QQDSQELLHY 
       310        320        330        340        350        360 
LLDAVRTEET KRIQASILKA FNNPTTKTAD DETRKKVKAY GKEGVKMNFI DRIFIGELTS 
       370        380        390        400        410        420 
TVMCEECANI STVKDPFIDI SLPIIEERVS KPLLWGRMNK YRSLRETDHD RYSGNVTIEN 
       430        440        450        460        470        480 
IHQPRAAKKH SSSKDKSQLI HDRKCIRKLS SGETVTYQKN ENLEMNGDSL MFASLMNSES 
       490        500        510        520        530        540 
RLNESPTDDS EKEASHSESN VDADSEPSES ESASKQTGLF RSSSGSGVQP DGPLYPLSAG 
       550        560        570        580        590        600 
KLLYTKETDS GDKEMAEAIS ELRLSSTVTG DQDFDRENQP LNISNNLCFL EGKHLRSYSP 
       610        620        630        640        650        660 
QNAFQTLSQS YITTSKECSI QSCLYQFTSM ELLMGNNKLL CENCTKNKQK YQEETSFAEK 
       670        680        690        700        710        720 
KVEGVYTNAR KQLLISAVPA VLILHLKRFH QAGLSLRKVN RHVDFPLMLD LAPFCSATCK 
       730        740        750        760        770        780 
NASVGDKVLY GLYGIVEHSG SMREGHYTAY VKVRTPSRKL SEHNTKKKNV PGLKAADNES 
       790        800        810    
AGQWVHVSDT YLQVVPESRA LSAQAYLLFY ERVL

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 45 - Isoform 3 of Ubiquitin carboxyl-terminal hydrolase 45

Sequence View

        10         20         30         40         50         60 
MRVKDPTKAL PEKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 
        70         80         90        100        110        120 
VCSECLKERR FYDGQLVLTS DIWLCLKCGF QGCGKNSESQ HSLKHFKSSR TEPHCIIINL 
       130        140        150        160        170        180 
STWIIWCYEC DEKLSTHCNK KVLAQIVDFL QKHASKTQTS AFSRIMKLCE EKCETDEIQK 
       190        200        210        220        230        240 
GGKCRNLSVR GITNLGNTCF FNAVMQNLAQ TYTLTDLMNE IKESSTKLKI FPSSDSQLDP 
       250        260        270        280        290        300 
LVVELSRPGP LTSALFLFLH SMKETEKGPL SPKVLFNQLC QKAPRFKDFQ QQDSQELLHY 
       310        320        330        340        350        360 
LLDAVRTEET KRIQASILKA FNNPTTKTAD DETRKKVKAY GKEGVKMNFI DRIFIGELTS 
       370        380        390        400        410        420 
TVMCEECANI STVKDPFIDI SLPIIEERVS KPLLWGRMNK YRSLRETDHD RYSGNVTIEN 
       430        440        450        460        470        480 
IHQPRAAKKH SSSKDKSQLI HDRKCIRKLS SGETVTYQKN ENLEMNGDSL MFASLMNSES 
       490        500        510        520        530        540 
RLNESPTDDS EKEASHSESN VDADSEPSES ESASKQTGLF RSSSGSGVQP DGPLYPLSAG 
       550        560        570        580        590        600 
KLLYTKETDS GDKEMAEAIS ELRLSSTVTG DQDFDRENQP LNISNNLCFL EGKHLRSYSP 
       610        620        630        640        650        660 
QNAFQTLSQS YITTSKECSI QSCLYQFTSM ELLMGNNKLL CENCTKNKQK YQEETSFAEK 
       670        680        690        700        710        720 
KVEGVYTNAR KQLLISAVPA VLILHLKRFH QAGLSLRKVN RHVDFPLMLD LAPFCSATCK 
       730        740        750        760        770        780 
NASVGDKVLY GLYGIVEHSG SMREGHYTAY VKVRTPSRKL SEHNTKKKNV PGLKAADNES 
       790        800        810    
AGQWVHVSDT YLQVVPESRA LSAQAYLLFY ERVL         10         20         30         40         50         60 
MRVKDPTKAL PEKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 
        70         80         90        100        110        120 
VCSECLKERR FYDGQLVLTS DIWLCLKCGF QGCGKNSESQ HSLKHFKSSR TEPHCIIINL 
       130        140        150        160        170        180 
STWIIWCYEC DEKLSTHCNK KVLAQIVDFL QKHASKTQTS AFSRIMKLCE EKCETDEIQK 
       190        200        210        220        230        240 
GGKCRNLSVR GITNLGNTCF FNAVMQNLAQ TYTLTDLMNE IKESSTKLKI FPSSDSQLDP 
       250        260        270        280        290        300 
LVVELSRPGP LTSALFLFLH SMKETEKGPL SPKVLFNQLC QKAPRFKDFQ QQDSQELLHY 
       310        320        330        340        350        360 
LLDAVRTEET KRIQASILKA FNNPTTKTAD DETRKKVKAY GKEGVKMNFI DRIFIGELTS 
       370        380        390        400        410        420 
TVMCEECANI STVKDPFIDI SLPIIEERVS KPLLWGRMNK YRSLRETDHD RYSGNVTIEN 
       430        440        450        460        470        480 
IHQPRAAKKH SSSKDKSQLI HDRKCIRKLS SGETVTYQKN ENLEMNGDSL MFASLMNSES 
       490        500        510        520        530        540 
RLNESPTDDS EKEASHSESN VDADSEPSES ESASKQTGLF RSSSGSGVQP DGPLYPLSAG 
       550        560        570        580        590        600 
KLLYTKETDS GDKEMAEAIS ELRLSSTVTG DQDFDRENQP LNISNNLCFL EGKHLRSYSP 
       610        620        630        640        650        660 
QNAFQTLSQS YITTSKECSI QSCLYQFTSM ELLMGNNKLL CENCTKNKQK YQEETSFAEK 
       670        680        690        700        710        720 
KVEGVYTNAR KQLLISAVPA VLILHLKRFH QAGLSLRKVN RHVDFPLMLD LAPFCSATCK 
       730        740        750        760        770        780 
NASVGDKVLY GLYGIVEHSG SMREGHYTAY VKVRTPSRKL SEHNTKKKNV PGLKAADNES 
       790        800        810    
AGQWVHVSDT YLQVVPESRA LSAQAYLLFY ERVL



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Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q70EL2-1-unknown MRVKDP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q70EL2-1-unknown MRVKDP... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt93704

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...YERVL 814 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...YERVL 814 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt89323

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates