Q9H9J4: Ubiquitin carboxyl-terminal hydrolase 42

General Information

Protein names	- Ubiquitin carboxyl-terminal hydrolase 42 - 3.4.19.12 - Deubiquitinating enzyme 42 - Ubiquitin thioesterase 42 - Ubiquitin-specific-processing protease 42
Gene names	USP42
Organism	Homo sapiens
Protease Family	C19.048
Protease ID	C19.048
Chromosome location
UniProt ID	Q9H9J4

4 N-termini

1 C-termini

0 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA
        70         80         90        100        110        120
VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC
       130        140        150        160        170        180
FANAALQCLT YTPPLANYML SHEHSKTCHA EGFCMMCTMQ AHITQALSNP GDVIKPMFVI
       190        200        210        220        230        240
NEMRRIARHF RFGNQEDAHE FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS
       250        260        270        280        290        300
RVKCLNCKGV SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
       310        320        330        340        350        360
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE PIVYVLYAVL
       370        380        390        400        410        420
VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL SQQAYVLFYI RSHDVKNGGE
       430        440        450        460        470        480
LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS
       490        500        510        520        530        540
MSSPNGNSSV NRASPVNASA SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN
       550        560        570        580        590        600
LHSNSLENPT KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN
       610        620        630        640        650        660
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE LQEPMTLNGA
       670        680        690        700        710        720
NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP GKLMPAPLLS LPEDKILETF
       730        740        750        760        770        780
RLSNKLKGST DEMSAPGAER GPPEDRDAEP QPGSPAAESL EEPDAAAGLS STKKAPPPRD
       790        800        810        820        830        840
PGTPATKEGA WEAMAVAPEE PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA
       850        860        870        880        890        900
EGPRDSALAE APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP
       910        920        930        940        950        960
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR GHYRSRRERS
       970        980        990       1000       1010       1020
SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP GHGDRLSPGE RRSLGRCSHH
      1030       1040       1050       1060       1070       1080
HSRHRSGVEL DWVRHHYTEG ERGWGREKFY PDRPRWDRCR YYHDRYALYA ARDWKPFHGG
      1090       1100       1110       1120       1130       1140
REHERAGLHE RPHKDHNRGR RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV
      1150       1160       1170       1180       1190       1200
AGDNCNLSDR FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK
      1210       1220       1230       1240       1250       1260
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF VKDSELHLPR
      1270       1280       1290       1300       1310       1320
VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM ESRDDRCRLF EYGQGKRRYL

ELGR

Isoforms

- Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 42

Sequence View

        10         20         30         40         50         60
MTIVDKASES SDPSAYQNQP GSSEAVSPGD MDAGSASWGA VSSLNDVSNH TLSLGPVPGA
        70         80         90        100        110        120
VVYSSSSVPD KSKPSPQKDQ ALGDGIAPPQ KVLFPSEKIC LKWQQTHRVG AGLQNLGNTC
       130        140        150        160        170        180
FANAALQCLT YTPPLANYML SHEHSKTCHA EGFCMMCTMQ AHITQALSNP GDVIKPMFVI
       190        200        210        220        230        240
NEMRRIARHF RFGNQEDAHE FLQYTVDAMQ KACLNGSNKL DRHTQATTLV CQIFGGYLRS
       250        260        270        280        290        300
RVKCLNCKGV SDTFDPYLDI TLEIKAAQSV NKALEQFVKP EQLDGENSYK CSKCKKMVPA
       310        320        330        340        350        360
SKRFTIHRSS NVLTLSLKRF ANFTGGKIAK DVKYPEYLDI RPYMSQPNGE PIVYVLYAVL
       370        380        390        400        410        420
VHTGFNCHAG HYFCYIKASN GLWYQMNDSI VSTSDIRSVL SQQAYVLFYI RSHDVKNGGE
       430        440        450        460        470        480
LTHPTHSPGQ SSPRPVISQR VVTNKQAAPG FIGPQLPSHM IKNPPHLNGT GPLKDTPSSS
       490        500        510        520        530        540
MSSPNGNSSV NRASPVNASA SVQNWSVNRS SVIPEHPKKQ KITISIHNKL PVRQCQSQPN
       550        560        570        580        590        600
LHSNSLENPT KPVPSSTITN SAVQSTSNAS TMSVSSKVTK PIPRSESCSQ PVMNGKSKLN
       610        620        630        640        650        660
SSVLVPYGAE SSEDSDEESK GLGKENGIGT IVSSHSPGQD AEDEEATPHE LQEPMTLNGA
       670        680        690        700        710        720
NSADSDSDPK ENGLAPDGAS CQGQPALHSE NPFAKANGLP GKLMPAPLLS LPEDKILETF
       730        740        750        760        770        780
RLSNKLKGST DEMSAPGAER GPPEDRDAEP QPGSPAAESL EEPDAAAGLS STKKAPPPRD
       790        800        810        820        830        840
PGTPATKEGA WEAMAVAPEE PPPSAGEDIV GDTAPPDLCD PGSLTGDASP LSQDAKGMIA
       850        860        870        880        890        900
EGPRDSALAE APEGLSPAPP ARSEEPCEQP LLVHPSGDHA RDAQDPSQSL GAPEAAERPP
       910        920        930        940        950        960
APVLDMAPAG HPEGDAEPSP GERVEDAAAP KAPGPSPAKE KIGSLRKVDR GHYRSRRERS
       970        980        990       1000       1010       1020
SSGEPARESR SKTEGHRHRR RRTCPRERDR QDRHAPEHHP GHGDRLSPGE RRSLGRCSHH
      1030       1040       1050       1060       1070       1080
HSRHRSGVEL DWVRHHYTEG ERGWGREKFY PDRPRWDRCR YYHDRYALYA ARDWKPFHGG
      1090       1100       1110       1120       1130       1140
REHERAGLHE RPHKDHNRGR RGCEPARERE RHRPSSPRAG APHALAPHPD RFSHDRTALV
      1150       1160       1170       1180       1190       1200
AGDNCNLSDR FHEHENGKSR KRRHDSVENS DSHVEKKARR SEQKDPLEEP KAKKHKKSKK
      1210       1220       1230       1240       1250       1260
KKKSKDKHRD RDSRHQQDSD LSAACSDADL HRHKKKKKKK KRHSRKSEDF VKDSELHLPR
      1270       1280       1290       1300       1310       1320
VTSLETVAQF RRAQGGFPLS GGPPLEGVGP FREKTKHLRM ESRDDRCRLF EYGQGKRRYL

ELGR

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H9J4-1-unknown	MTIVDK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H9J4-1-unknown	MTIVDK...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt93699
Q9H9J4-683-unknown	GQPALH...	683		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H9J4-683-unknown	GQPALH...	683	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162278
Q9H9J4-765-	AAAGLS...	765		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
Q9H9J4-765-	AAAGLS...	765		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9H9J4-765-unknown	AAAGLS...	765		unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9H9J4-765-unknown	AAAGLS...	765	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162276

TopFIND

Q9H9J4: Ubiquitin carboxyl-terminal hydrolase 42

General Information

4

N-termini

1

C-termini

0

Cleavages

1

Substrates

Sequence

Isoforms

Filter Information:

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Methodology:

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Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

Substrates