Q9Y285: Phenylalanine--tRNA ligase alpha subunit

General Information

Protein names	- Phenylalanine--tRNA ligase alpha subunit - 6.1.1.20 {ECO:0000269\|PubMed:20223217} - CML33 - Phenylalanyl-tRNA synthetase alpha subunit - PheRS
Gene names	FARSA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9Y285

8 N-termini

5 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADGQVAELL LRRLEASDGG LDSAELAAEL GMEHQAVVGA VKSLQALGEV IEAELRSTKH
        70         80         90        100        110        120
WELTAEGEEI AREGSHEARV FRSIPPEGLA QSELMRLPSG KVGFSKAMSN KWIRVDKSAA
       130        140        150        160        170        180
DGPRVFRVVD SMEDEVQRRL QLVRGGQAEK LGEKERSELR KRKLLAEVTL KTYWVSKGSA
       190        200        210        220        230        240
FSTSISKQET ELSPEMISSG SWRDRPFKPY NFLAHGVLPD SGHLHPLLKV RSQFRQIFLE
       250        260        270        280        290        300
MGFTEMPTDN FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM DYVQRVKRTH
       310        320        330        340        350        360
SQGGYGSQGY KYNWKLDEAR KNLLRTHTTS ASARALYRLA QKKPFTPVKY FSIDRVFRNE
       370        380        390        400        410        420
TLDATHLAEF HQIEGVVADH GLTLGHLMGV LREFFTKLGI TQLRFKPAYN PYTEPSMEVF
       430        440        450        460        470        480
SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE NVSVIAWGLS LERPTMIKYG INNIRELVGH
       490        500
KVNLQMVYDS PLCRLDAEPR PPPTQEAA

Isoforms

- Isoform 2 of Phenylalanine--tRNA ligase alpha subunit

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 5 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9Y285-2-unknown	MADGQV...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y285-2-Acetylation	ADGQVA...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9Y285-2-Acetylation	ADGQVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9Y285-2-Acetylation	ADGQVA...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q9Y285-2-Acetylation	ADGQVA...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9Y285-2-Acetylation	ADGQVA...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
Q9Y285-43-	SLQALG...	43			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y285-46-unknown	ALGEVI...	46		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6931
Q9Y285-83-	SIPPEG...	83			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q9Y285-115-unknown	VDKSAA...	115			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y285-115-unknown	VDKSAA...	115			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q9Y285-115-	VDKSAA...	115			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
Q9Y285-115-	VDKSAA...	115			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q9Y285-115-	VDKSAA...	115			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q9Y285-115-	VDKSAA...	115			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q9Y285-221-unknown	SGHLHP...	221		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13600

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...VKSLQA	45	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6931
...GVLPDS	220	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC13600
...GLSLER	462	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000467384
...TQEAA	508		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...TQEAA	508	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...TQEAA	508		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	45	SLQA.\|.ALGE	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
GRAB_HUMAN	220	LPDS.\|.SGHL	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Analysis of protein processing ... (S01.010)	18836177,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)