Q9UN37: Vacuolar protein sorting-associated protein 4A

General Information

Protein names	- Vacuolar protein sorting-associated protein 4A - 3.6.4.6 - Protein SKD2 - VPS4-1 - hVPS4
Gene names	VPS4A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9UN37

4 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MTTSTLQKAI DLVTKATEED KAKNYEEALR LYQHAVEYFL HAIKYEAHSD KAKESIRAKC
        70         80         90        100        110        120
VQYLDRAEKL KDYLRSKEKH GKKPVKENQS EGKGSDSDSE GDNPEKKKLQ EQLMGAVVME
       130        140        150        160        170        180
KPNIRWNDVA GLEGAKEALK EAVILPIKFP HLFTGKRTPW RGILLFGPPG TGKSYLAKAV
       190        200        210        220        230        240
ATEANNSTFF SVSSSDLMSK WLGESEKLVK NLFELARQHK PSIIFIDEVD SLCGSRNENE
       250        260        270        280        290        300
SEAARRIKTE FLVQMQGVGN NNDGTLVLGA TNIPWVLDSA IRRRFEKRIY IPLPEEAARA
       310        320        330        340        350        360
QMFRLHLGST PHNLTDANIH ELARKTEGYS GADISIIVRD SLMQPVRKVQ SATHFKKVCG
       370        380        390        400        410        420
PSRTNPSMMI DDLLTPCSPG DPGAMEMTWM DVPGDKLLEP VVCMSDMLRS LATTRPTVNA
       430
DDLLKVKKFS EDFGQES

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9UN37-2-unknown	MTTSTL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UN37-2-Acetylation	TTSTLQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9UN37-2-Acetylation	TTSTLQ...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9UN37-148-unknown	KFPHLF...	148		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC15551
Q9UN37-413-unknown	TTRPTV...	413		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC6866

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VILPIK	147	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15551
...LRSLAT	412	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6866
...FGQES	437	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HTRA2_HUMAN	147	LPIK.\|.KFPH	inferred from experiment	unknown	MEROPS	Vandenabeele P	Vande Walle L et al.:Proteome-wide Identification of... (S01.278)	17266347,
CATL1_HUMAN	412	SLAT.\|.TTRP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)