Q9BT78: COP9 signalosome complex subunit 4

General Information

Protein names	- COP9 signalosome complex subunit 4 - SGN4 - Signalosome subunit 4 - JAB1-containing signalosome subunit 4
Gene names	COPS4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BT78

6 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAAVRQDLA QLMNSSGSHK DLAGKYRQIL EKAIQLSGAE QLEALKAFVE AMVNENVSLV
        70         80         90        100        110        120
ISRQLLTDFC THLPNLPDST AKEIYHFTLE KIQPRVISFE EQVASIRQHL ASIYEKEEDW
       130        140        150        160        170        180
RNAAQVLVGI PLETGQKQYN VDYKLETYLK IARLYLEDDD PVQAEAYINR ASLLQNESTN
       190        200        210        220        230        240
EQLQIHYKVC YARVLDYRRK FIEAAQRYNE LSYKTIVHES ERLEALKHAL HCTILASAGQ
       250        260        270        280        290        300
QRSRMLATLF KDERCQQLAA YGILEKMYLD RIIRGNQLQE FAAMLMPHQK ATTADGSSIL
       310        320        330        340        350        360
DRAVIEHNLL SASKLYNNIT FEELGALLEI PAAKAEKIAS QMITEGRMNG FIDQIDGIVH
       370        380        390        400
FETREALPTW DKQIQSLCFQ VNNLLEKISQ TAPEWTAQAM EAQMAQ

Isoforms

- Isoform 2 of COP9 signalosome complex subunit 4

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9BT78-1-unknown	MAAAVR...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71910
Q9BT78-2-unknown	MAAAVR...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BT78-2-Acetylation	AAAVRQ...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BT78-2-Acetylation	AAAVRQ...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110774
Q9BT78-36-unknown	LSGAEQ...	36		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6729
Q9BT78-36-unknown	LSGAEQ...	36		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4233
Q9BT78-36-unknown	LSGAEQ...	36		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138014
Q9BT78-71-unknown	THLPNL...	71		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6731
Q9BT78-71-unknown	THLPNL...	71		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140709
Q9BT78-72-unknown	HLPNLP...	72		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8053
Q9BT78-72-unknown	HLPNLP...	72		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140778

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EKAIQL	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6729
...EKAIQL	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4233
...EKAIQL	35	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121030
...LTDFCT	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6731
...LTDFCT	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123844
...TDFCTH	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8053
...TDFCTH	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123913
...AQMAQ	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	35	AIQL.\|.LSGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATB_HUMAN	35	AIQL.\|.LSGA	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	70	DFCT.\|.THLP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	71	FCTH.\|.HLPN	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)