P46940: Ras GTPase-activating-like protein IQGAP1

General Information

Protein names	- Ras GTPase-activating-like protein IQGAP1 - p195
Gene names	IQGAP1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P46940

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSAADEVDGL GVARPHYGSV LDNERLTAEE MDERRRQNVA YEYLCHLEEA KRWMEACLGE
        70         80         90        100        110        120
DLPPTTELEE GLRNGVYLAK LGNFFSPKVV SLKKIYDREQ TRYKATGLHF RHTDNVIQWL
       130        140        150        160        170        180
NAMDEIGLPK IFYPETTDIY DRKNMPRCIY CIHALSLYLF KLGLAPQIQD LYGKVDFTEE
       190        200        210        220        230        240
EINNMKTELE KYGIQMPAFS KIGGILANEL SVDEAALHAA VIAINEAIDR RIPADTFAAL
       250        260        270        280        290        300
KNPNAMLVNL EEPLASTYQD ILYQAKQDKM TNAKNRTENS ERERDVYEEL LTQAEIQGNI
       310        320        330        340        350        360
NKVNTFSALA NIDLALEQGD ALALFRALQS PALGLRGLQQ QNSDWYLKQL LSDKQQKRQS
       370        380        390        400        410        420
GQTDPLQKEE LQSGVDAANS AAQQYQRRLA AVALINAAIQ KGVAEKTVLE LMNPEAQLPQ
       430        440        450        460        470        480
VYPFAADLYQ KELATLQRQS PEHNLTHPEL SVAVEMLSSV ALINRALESG DVNTVWKQLS
       490        500        510        520        530        540
SSVTGLTNIE EENCQRYLDE LMKLKAQAHA ENNEFITWND IQACVDHVNL VVQEEHERIL
       550        560        570        580        590        600
AIGLINEALD EGDAQKTLQA LQIPAAKLEG VLAEVAQHYQ DTLIRAKREK AQEIQDESAV
       610        620        630        640        650        660
LWLDEIQGGI WQSNKDTQEA QKFALGIFAI NEAVESGDVG KTLSALRSPD VGLYGVIPEC
       670        680        690        700        710        720
GETYHSDLAE AKKKKLAVGD NNSKWVKHWV KGGYYYYHNL ETQEGGWDEP PNFVQNSMQL
       730        740        750        760        770        780
SREEIQSSIS GVTAAYNREQ LWLANEGLIT RLQARCRGYL VRQEFRSRMN FLKKQIPAIT
       790        800        810        820        830        840
CIQSQWRGYK QKKAYQDRLA YLRSHKDEVV KIQSLARMHQ ARKRYRDRLQ YFRDHINDII
       850        860        870        880        890        900
KIQAFIRANK ARDDYKTLIN AEDPPMVVVR KFVHLLDQSD QDFQEELDLM KMREEVITLI
       910        920        930        940        950        960
RSNQQLENDL NLMDIKIGLL VKNKITLQDV VSHSKKLTKK NKEQLSDMMM INKQKGGLKA
       970        980        990       1000       1010       1020
LSKEKREKLE AYQHLFYLLQ TNPTYLAKLI FQMPQNKSTK FMDSVIFTLY NYASNQREEY
      1030       1040       1050       1060       1070       1080
LLLRLFKTAL QEEIKSKVDQ IQEIVTGNPT VIKMVVSFNR GARGQNALRQ ILAPVVKEIM
      1090       1100       1110       1120       1130       1140
DDKSLNIKTD PVDIYKSWVN QMESQTGEAS KLPYDVTPEQ ALAHEEVKTR LDSSIRNMRA
      1150       1160       1170       1180       1190       1200
VTDKFLSAIV SSVDKIPYGM RFIAKVLKDS LHEKFPDAGE DELLKIIGNL LYYRYMNPAI
      1210       1220       1230       1240       1250       1260
VAPDAFDIID LSAGGQLTTD QRRNLGSIAK MLQHAASNKM FLGDNAHLSI INEYLSQSYQ
      1270       1280       1290       1300       1310       1320
KFRRFFQTAC DVPELQDKFN VDEYSDLVTL TKPVIYISIG EIINTHTLLL DHQDAIAPEH
      1330       1340       1350       1360       1370       1380
NDPIHELLDD LGEVPTIESL IGESSGNLND PNKEALAKTE VSLTLTNKFD VPGDENAEMD
      1390       1400       1410       1420       1430       1440
ARTILLNTKR LIVDVIRFQP GETLTEILET PATSEQEAEH QRAMQRRAIR DAKTPDKMKK
      1450       1460       1470       1480       1490       1500
SKSVKEDSNL TLQEKKEKIQ TGLKKLTELG TVDPKNKYQE LINDIARDIR NQRRYRQRRK
      1510       1520       1530       1540       1550       1560
AELVKLQQTY AALNSKATFY GEQVDYYKSY IKTCLDNLAS KGKVSKKPRE MKGKKSKKIS
      1570       1580       1590       1600       1610       1620
LKYTAARLHE KGVLLEIEDL QVNQFKNVIF EISPTEEVGD FEVKAKFMGV QMETFMLHYQ
      1630       1640       1650
DLLQLQYEGV AVMKLFDRAK VNVNLLIFLL NKKFYGK

Isoforms

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P46940-2-unknown	MSAADE...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46940-2-Acetylation	SAADEV...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P46940-2-Acetylation	SAADEV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
P46940-2-Acetylation	SAADEV...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P46940-2-Acetylation	SAADEV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P46940-9-unknown	GLGVAR...	9		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1226
P46940-9-unknown	GLGVAR...	9			unknown			Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_Etoposide	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apopotic_Jurkat_FasL	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P46940-9-	GLGVAR...	9			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P46940-145-unknown	MPRCIY...	145		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000452723
P46940-1410-unknown	TPATSE...	1410		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5891
P46940-1410-unknown	TPATSE...	1410		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7480

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ADEVDG	8	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1226
...NNMKTE	187	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000452723
...TEILET	1409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5891
...TEILET	1409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7480
...KFYGK	1657	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	8	EVDG.\|.GLGV	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,
CATL1_HUMAN	1409	ILET.\|.TPAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATS_HUMAN	1409	ILET.\|.TPAT	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)