P17812: CTP synthase 1 {ECO:0000305}

General Information

Protein names	- CTP synthase 1 {ECO:0000305} - 6.3.4.2 {ECO:0000269\|PubMed:16179339, ECO:0000269\|PubMed:24870241} - CTP synthetase 1 - UTP--ammonia ligase 1
Gene names	CTPS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P17812

5 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKYILVTGGV ISGIGKGIIA SSVGTILKSC GLHVTSIKID PYINIDAGTF SPYEHGEVFV
        70         80         90        100        110        120
LDDGGEVDLD LGNYERFLDI RLTKDNNLTT GKIYQYVINK ERKGDYLGKT VQVVPHITDA
       130        140        150        160        170        180
IQEWVMRQAL IPVDEDGLEP QVCVIELGGT VGDIESMPFI EAFRQFQFKV KRENFCNIHV
       190        200        210        220        230        240
SLVPQPSSTG EQKTKPTQNS VRELRGLGLS PDLVVCRCSN PLDTSVKEKI SMFCHVEPEQ
       250        260        270        280        290        300
VICVHDVSSI YRVPLLLEEQ GVVDYFLRRL DLPIERQPRK MLMKWKEMAD RYDRLLETCS
       310        320        330        340        350        360
IALVGKYTKF SDSYASVIKA LEHSALAINH KLEIKYIDSA DLEPITSQEE PVRYHEAWQK
       370        380        390        400        410        420
LCSAHGVLVP GGFGVRGTEG KIQAIAWARN QKKPFLGVCL GMQLAVVEFS RNVLGWQDAN
       430        440        450        460        470        480
STEFDPTTSH PVVVDMPEHN PGQMGGTMRL GKRRTLFQTK NSVMRKLYGD ADYLEERHRH
       490        500        510        520        530        540
RFEVNPVWKK CLEEQGLKFV GQDVEGERME IVELEDHPFF VGVQYHPEFL SRPIKPSPPY
       550        560        570        580        590
FGLLLASVGR LSHYLQKGCR LSPRDTYSDR SGSSSPDSEI TELKFPSINH D

Isoforms

- Isoform 2 of CTP synthase 1

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P17812-1-unknown	MKYILV...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P17812-8-unknown	GGVISG...	8	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5627
P17812-232-unknown	MFCHVE...	232	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000442646
P17812-336-	YIDSAD...	336		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P17812-499-	FVGQDV...	499		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P17812-499-	FVGQDV...	499		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...YILVTG	7	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5627
	...SINHD	591	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	7	LVTG.\|.GGVI	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)