O94906: Pre-mRNA-processing factor 6
Protein names | - Pre-mRNA-processing factor 6 - Androgen receptor N-terminal domain-transactivating protein 1 - ANT-1 - PRP6 homolog - U5 snRNP-associated 102 kDa protein - U5-102 kDa protein |
---|---|
Gene names | PRPF6 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | O94906 |
11
N-termini
4
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM
70 80 90 100 110 120
KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR
130 140 150 160 170 180
EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT
190 200 210 220 230 240
PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM
250 260 270 280 290 300
RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS
310 320 330 340 350 360
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA
370 380 390 400 410 420
VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR
430 440 450 460 470 480
IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT
490 500 510 520 530 540
QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK
550 560 570 580 590 600
HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA
610 620 630 640 650 660
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER
670 680 690 700 710 720
ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE
730 740 750 760 770 780
QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW
790 800 810 820 830 840
LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD
850 860 870 880 890 900
PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR
910 920 930 940
CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F
Isoforms
- Isoform 2 of Pre-mRNA-processing factor 6Sequence View
10 20 30 40 50 60
MNKKKKPFLG MPAPLGYVPG LGRGATGFTT RSDIGPARDA NDPVDDRHAP PGKRTVGDQM
70 80 90 100 110 120
KKNQAADDDD EDLNDTNYDE FNGYAGSLFS SGPYEKDDEE ADAIYAALDK RMDERRKERR
130 140 150 160 170 180
EQREKEEIEK YRMERPKIQQ QFSDLKRKLA EVTEEEWLSI PEVGDARNKR QRNPRYEKLT
190 200 210 220 230 240
PVPDSFFAKH LQTGENHTSV DPRQTQFGGL NTPYPGGLNT PYPGGMTPGL MTPGTGELDM
250 260 270 280 290 300
RKIGQARNTL MDMRLSQVSD SVSGQTVVDP KGYLTDLNSM IPTHGGDIND IKKARLLLKS
310 320 330 340 350 360
VRETNPHHPP AWIASARLEE VTGKLQVARN LIMKGTEMCP KSEDVWLEAA RLQPGDTAKA
370 380 390 400 410 420
VVAQAVRHLP QSVRIYIRAA ELETDIRAKK RVLRKALEHV PNSVRLWKAA VELEEPEDAR
430 440 450 460 470 480
IMLSRAVECC PTSVELWLAL ARLETYENAR KVLNKARENI PTDRHIWITA AKLEEANGNT
490 500 510 520 530 540
QMVEKIIDRA ITSLRANGVE INREQWIQDA EECDRAGSVA TCQAVMRAVI GIGIEEEDRK
550 560 570 580 590 600
HTWMEDADSC VAHNALECAR AIYAYALQVF PSKKSVWLRA AYFEKNHGTR ESLEALLQRA
610 620 630 640 650 660
VAHCPKAEVL WLMGAKSKWL AGDVPAARSI LALAFQANPN SEEIWLAAVK LESENDEYER
670 680 690 700 710 720
ARRLLAKARS SAPTARVFMK SVKLEWVQDN IRAAQDLCEE ALRHYEDFPK LWMMKGQIEE
730 740 750 760 770 780
QKEMMEKARE AYNQGLKKCP HSTPLWLLLS RLEEKIGQLT RARAILEKSR LKNPKNPGLW
790 800 810 820 830 840
LESVRLEYRA GLKNIANTLM AKALQECPNS GILWSEAIFL EARPQRRTKS VDALKKCEHD
850 860 870 880 890 900
PHVLLAVAKL FWSQRKITKA REWFHRTVKI DSDLGDAWAF FYKFELQHGT EEQQEEVRKR
910 920 930 940
CESAEPRHGE LWCAVSKDIA NWQKKIGDIL RLVAGRIKNT F
Protein Neighborhood
Domains & Features
11 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
O94906-1-unknown | MNKKKK... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
O94906-1-unknown | MNKKKK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86274 | |||
O94906-7-unknown | PFLGMP... | 7 | inferred from electronic annotation | unknown | TISdb | inferred from TISdb | |||
O94906-7-unknown | PFLGMP... | 7 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt194756 | |||
O94906-176-unknown | YEKLTP... | 176 | unknown | Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage... | 18722006 | ||||
O94906-176-unknown | YEKLTP... | 176 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt160076 | |||
O94906-176- | YEKLTP... | 176 | Subtiligase Based Positive Selection | Wells | Jurkat_untreated | 23264352 | |||
O94906-185-unknown | SFFAKH... | 185 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10991 | |||
O94906-185-unknown | SFFAKH... | 185 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt146090 | |||
O94906-279-unknown | SMIPTH... | 279 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt168140 | |||
O94906-279- | SMIPTH... | 279 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_bortezomib | 23264352 | |||
O94906-409- | AAVELE... | 409 | Subtiligase Based Positive Selection | Wells | apoptotic_Jurkat_staurotrail | 23264352 | |||
O94906-409- | AAVELE... | 409 | Subtiligase Based Positive Selection | Wells | apoptotic_MM1SDBJurkat_Mix | 23264352 | |||
O94906-409-unknown | AAVELE... | 409 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt171600 | |||
O94906-527-unknown | RAVIGI... | 527 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13854 | |||
O94906-527-unknown | RAVIGI... | 527 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153706 | |||
O94906-888-unknown | HGTEEQ... | 888 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7075 | |||
O94906-888-unknown | HGTEEQ... | 888 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5284 | |||
O94906-888-unknown | HGTEEQ... | 888 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt156685 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...TPVPDS | 184 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC10991 | |||
...TPVPDS | 184 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt129390 | |||
...CQAVMR | 526 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC13854 | |||
...CQAVMR | 526 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137129 | |||
...KFELQH | 887 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC7075 | |||
...KFELQH | 887 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC5284 | |||
...KFELQH | 887 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt140171 | |||
...IKNTF | 941 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...IKNTF | 941 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt81892 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
GRAB_HUMAN | 184 | VPDS.|.SFFA | inferred from experiment | unknown | MEROPS | Gevaert K | Van Damme P et al.:Complementary positional proteo... (M14.017) | 20526345, |
GRAM_HUMAN | 526 | AVMR.|.RAVI | inferred from experiment | unknown | MEROPS | Bovenschen N | de Poot SA et al.:Human and mouse granzyme M disp... (S01.139) | 21564021, |
CATS_HUMAN | 887 | ELQH.|.HGTE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
CATL1_HUMAN | 887 | ELQH.|.HGTE | inferred from experiment | unknown | MEROPS | Schilling O | Biniossek ML et al.:Proteomic identification of pro... (C01.060) | 21967108, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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